Trial Outcomes & Findings for Comparing the Effects of Upper and Lower Body Resistance Training on Pain Sensitivity (NCT NCT05985382)

NCT ID: NCT05985382

Last Updated: 2025-03-04

Results Overview

For pressure pain threshold, an algometer was gradually increased until the sensation changed from pressure to pain. Pressure at threshold was recorded in kilopascals.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

30 participants

Primary outcome timeframe

Pressure pain threshold will be applied to the quadriceps immediately after each exercise.

Results posted on

2025-03-04

Participant Flow

Participant milestones

Participant milestones
Measure
Lower Then Upper Body Resistance Exercise
Participants will perform a lower body resistance exercise first then upper body resistance exercise. This is a cross-over design. Lower Body Resistance Exercise: Participants will complete a leg extension exercise with weight equivalent to 75% of their estimated 1-repetition maximum 3 sets, 10 repetitions. Participants will perform a shoulder press with weight that is 75% of their estimated 1-repetition maximum (1-RM) for 3 sets of 10 repetitions. Upper Body Resistance Exercise: Participants will complete a leg extension exercise with weight equivalent to 75% of their estimated 1-repetition maximum 3 sets, 10 repetitions.
Upper Then Lower Body Resistance Exercise
Participants will perform a upper body resistance exercise first then upper body resistance exercise. This is a cross-over design. Upper Body Resistance Exercise: Participants will complete a leg extension exercise with weight equivalent to 75% of their estimated 1-repetition maximum 3 sets, 10 repetitions. Lower Body Resistance Exercise: Participants will complete a leg extension exercise with weight equivalent to 75% of their estimated 1-repetition maximum 3 sets, 10 repetitions. Participants will perform a shoulder press with weight that is 75% of their estimated 1-repetition maximum (1-RM) for 3 sets of 10 repetitions.
Overall Study
STARTED
15
15
Overall Study
COMPLETED
15
15
Overall Study
NOT COMPLETED
0
0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Comparing the Effects of Upper and Lower Body Resistance Training on Pain Sensitivity

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
Upper and Lower Body Resistance Exercise
n=30 Participants
All participants will perform a leg extension exercise with weight that is 75% of their estimated 1-repetition maximum (1-RM) for 3 sets of 10 repetitions. Lower Body Resistance Exercise: Participants will complete a leg extension exercise with weight equivalent to 75% of their estimated 1-repetition maximum 3 sets, 10 repetitions. Participants will perform a shoulder press with weight that is 75% of their estimated 1-repetition maximum (1-RM) for 3 sets of 10 repetitions. Upper Body Resistance Exercise: Participants will complete a leg extension exercise with weight equivalent to 75% of their estimated 1-repetition maximum 3 sets, 10 repetitions.
Age, Categorical
<=18 years
0 Participants
n=5 Participants
Age, Categorical
Between 18 and 65 years
30 Participants
n=5 Participants
Age, Categorical
>=65 years
0 Participants
n=5 Participants
Age, Continuous
21 years
STANDARD_DEVIATION 4 • n=5 Participants
Sex: Female, Male
Female
21 Participants
n=5 Participants
Sex: Female, Male
Male
9 Participants
n=5 Participants
Ethnicity (NIH/OMB)
Hispanic or Latino
9 Participants
n=5 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
21 Participants
n=5 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
0 Participants
n=5 Participants
Region of Enrollment
United States
30 Participants
n=5 Participants

PRIMARY outcome

Timeframe: Pressure pain threshold will be applied to the quadriceps immediately after each exercise.

For pressure pain threshold, an algometer was gradually increased until the sensation changed from pressure to pain. Pressure at threshold was recorded in kilopascals.

Outcome measures

Outcome measures
Measure
Lower Body Resistance Exercise
n=30 Participants
Participants will perform a leg extension exercise with weight that is 75% of their estimated 1-repetition maximum (1-RM) for 3 sets of 10 repetitions. Lower Body Resistance Exercise: Participants will complete a leg extension exercise with weight equivalent to 75% of their estimated 1-repetition maximum 3 sets, 10 repetitions.
Upper Body Resistance Exercise
n=30 Participants
Participants will perform a shoulder press with weight that is 75% of their estimated 1-repetition maximum (1-RM) for 3 sets of 10 repetitions.
Lower Body Resistance Exercise
594.10 kilopascals
Standard Deviation 234.74
572.54 kilopascals
Standard Deviation 249.87

SECONDARY outcome

Timeframe: Heat Pain Threshold will be applied over the quadriceps before and after the exercise.

All participants completed Heat Pain Threshold. For heat pain threshold, a thermode will gradually warm up from 32 degrees Celsius until the participant reports the sensation changes from comfortable warmth to slightly unpleasant pain. The temperature at threshold will be recorded.

Outcome measures

Outcome measures
Measure
Lower Body Resistance Exercise
n=30 Participants
Participants will perform a leg extension exercise with weight that is 75% of their estimated 1-repetition maximum (1-RM) for 3 sets of 10 repetitions. Lower Body Resistance Exercise: Participants will complete a leg extension exercise with weight equivalent to 75% of their estimated 1-repetition maximum 3 sets, 10 repetitions.
Upper Body Resistance Exercise
n=30 Participants
Participants will perform a shoulder press with weight that is 75% of their estimated 1-repetition maximum (1-RM) for 3 sets of 10 repetitions.
Heat Pain Threshold
43.75 Degrees Celsius
Standard Deviation 3.27
43.56 Degrees Celsius
Standard Deviation 3.18

Adverse Events

Lower Body Then Upper Body Resistance Exercise

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Upper Body Then Lower Body Resistance Exercise

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Abigail Anderson

University of Central Florida

Phone: 4078231026

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place