Use of a Diary to Assess and Monitor Behavioral and Psychological Symptoms of Dementia ( BPSDiary )

NCT ID: NCT05977855

Last Updated: 2023-10-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-07-01

Study Completion Date

2024-07-31

Brief Summary

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The goal of this randomized clinical trial is to compare the efficacy of the use of a diary to record behavioral and psychological symptoms of dementia (BPSD) in persons with dementia. The main questions it aims to answer are:

* Does the use of a diary lead to a reduction of the caregiver's burden at 3 months, compared with standard care?
* Does the use of a diary lead to a reduction of the neuropsychiatric inventory (NPI) score at 3 months, compared with standard care?
* Does the use of a diary result in less psychotropic drugs prescribed to the patient at 3 months compared with standard care?
* Are physicians and caregivers satisfied with managing patients with the use of a diary?
* Does the use of a diary reduce the caregiver's stress related to BPSD at 3 months, compared with standard care? Participants will be randomly assigned to either the use of a diary or a control group. Caregivers in the diary arm will be asked to fill in a diary with BPSD including triggers, severity, day and hour, to be analyzed by physicians to prescribe appropriate pharmacological or non-pharmacological interventions. The control group will receive usual care (i.e., appropriate interventions will be applied after interviewing the caregiver and/or visiting the patient).

Detailed Description

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Conditions

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Behavioral and Psychiatric Symptoms of Dementia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Diary

Group Type EXPERIMENTAL

BPSDiary

Intervention Type OTHER

The BPSDiary is a diary to register severity, hour, day and triggers of a number of BPSD (namely, agitation, aggression, delusions/hallucinations, insomnia, aberrant motor behavior).

Standard Care

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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BPSDiary

The BPSDiary is a diary to register severity, hour, day and triggers of a number of BPSD (namely, agitation, aggression, delusions/hallucinations, insomnia, aberrant motor behavior).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of cognitive impairment (neurodegenerative or vascular)
* Caregiver and patient willing to participate in the study
* Caregiver living with the patient or able to cover all 24 hours
* Presence of BPSD pertaining to the hyperactivity-irritability-impulsivity-disinhibition cluster (HIDA)
* Signed informed consent before the beginning of the study

Exclusion Criteria

* Refusal to consent to participate in the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondazione IRCCS San Gerardo dei Tintori

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Ospedale SS Annunziata

Chieti, Abruzzo, Italy

Site Status NOT_YET_RECRUITING

Pia Fondazione Card. Panico

Tricase, Apulia, Italy

Site Status NOT_YET_RECRUITING

Università Sapienza

Rome, Lazio, Italy

Site Status NOT_YET_RECRUITING

Ospedale Multimedica

Castellanza, Lombardy, Italy

Site Status NOT_YET_RECRUITING

Fondazione IRCCS Don Gnocchi

Milan, Lombardy, Italy

Site Status NOT_YET_RECRUITING

Fondazione IRCCS San Gerardo dei Tintori [Recruiting]

Monza, Lombardy, Italy

Site Status RECRUITING

Fondazione IRCCS Mondino

Pavia, Lombardy, Italy

Site Status NOT_YET_RECRUITING

AOU Careggi

Florence, Tuscany, Italy

Site Status NOT_YET_RECRUITING

AO Padova

Padua, Veneto, Italy

Site Status NOT_YET_RECRUITING

Countries

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Italy

Central Contacts

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Lucio Tremolizzo, MD, PhD

Role: CONTACT

+390392333595

Facility Contacts

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Laura Bonanni, MD, PhD

Role: primary

Giancarlo Logroscino, MD, PhD

Role: primary

Fabrizia D'Antonio, MD, PhD

Role: primary

Marta Zuffi, MD

Role: primary

Elisabetta Farina, MD

Role: primary

Lucio Tremolizzo, MD, PhD

Role: primary

+390392333595

Federico Emanuele Pozzi, MD

Role: backup

+393494113421

Alfredo Costa, MD, PhD

Role: primary

Valentina Bessi, MD, PhD

Role: primary

Annachiara Cagnin, MD, PhD

Role: primary

References

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Pozzi FE, Cali L, D'Antonio F, Altomare AI, Sepe Monti M, Panigutti M, Di Crosta A, Palumbo R, Bonanni L, Carlucci V, Busse C, Cagning A, Urso D, Vilella D, Logroscino G, Alberoni M, Bellinvia A, Farina E, de Rino F, Gavazzi A, Zuffi M, Bruno G, Bessi V, Cotta Ramusino M, Perini G, Costa A, Ferrarese C, Appollonio I, Tremolizzo L. BPSDiary study protocol: a multi-center randomized controlled trial to compare the efficacy of a BPSD diary vs. standard care in reducing caregiver's burden. Front Dement. 2023 Dec 18;2:1301280. doi: 10.3389/frdem.2023.1301280. eCollection 2023.

Reference Type DERIVED
PMID: 39081982 (View on PubMed)

Other Identifiers

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BPSDiary

Identifier Type: -

Identifier Source: org_study_id

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