Trial Outcomes & Findings for Pre vs Post Block in Total Knee Arthroplasty (TKA) (NCT NCT05974501)

NCT ID: NCT05974501

Last Updated: 2025-02-12

Results Overview

Scale with numeric scores ranging from 0 (least) to 10 (most) pain

• Recruitment status: COMPLETED
• Study phase: PHASE4
• Target enrollment: 84 participants
• Primary outcome timeframe: 2 hours postoperatively
• Results posted on: 2025-02-12

Participant Flow

Participant milestones

Measure	Preoperative Adductor Canal Block Group Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Overall Study STARTED	46	38
Overall Study COMPLETED	46	37
Overall Study NOT COMPLETED	0	1

Reasons for withdrawal

Measure	Preoperative Adductor Canal Block Group Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Overall Study Physician Decision	0	1

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=38 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Total n=84 Participants Total of all reporting groups
Age, Continuous	65 years STANDARD_DEVIATION 9.12 • n=46 Participants	65 years STANDARD_DEVIATION 9.75 • n=38 Participants	65 years STANDARD_DEVIATION 9.38 • n=84 Participants
Sex: Female, Male Female	31 Participants n=46 Participants	26 Participants n=38 Participants	57 Participants n=84 Participants
Sex: Female, Male Male	15 Participants n=46 Participants	12 Participants n=38 Participants	27 Participants n=84 Participants
Race and Ethnicity Not Collected	—	—	0 Participants Race and Ethnicity were not collected from any participant.
Body Mass Index (BMI)	30.50 kg/m^2 STANDARD_DEVIATION 4.73 • n=46 Participants	30.90 kg/m^2 STANDARD_DEVIATION 4.18 • n=38 Participants	30.80 kg/m^2 STANDARD_DEVIATION 4.51 • n=84 Participants

PRIMARY outcome

Timeframe: 2 hours postoperatively

Population: Patients who completed the study in one of the two groups

Scale with numeric scores ranging from 0 (least) to 10 (most) pain

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Pain Status as Measured by Numeric Pain Scale	2 score on a scale Interval 1.0 to 6.0	4.00 score on a scale Interval 1.0 to 5.0

PRIMARY outcome

Timeframe: 24 hours postoperatively

Population: Patients who completed the study in one of the two groups

Scale with numeric scores ranging from 0 (least) to 10 (most) pain

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Pain Status as Measured by Numeric Pain Scale	6.00 score on a scale Interval 4.0 to 7.0	6.00 score on a scale Interval 5.0 to 8.0

SECONDARY outcome

Timeframe: 2 hours postoperatively

Population: Patients who completed the study in one of the two groups

Count of the number of patients reporting nausea

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Patients Reporting Nausea	7 Participants	4 Participants

SECONDARY outcome

Timeframe: 2 hours postoperatively

Population: Patients who completed the study in one of the two groups

Count of the number of episodes of nausea per patient

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Episodes of Nausea	0.00 number of episodes per patient Interval 0.0 to 0.0	0.00 number of episodes per patient Interval 0.0 to 0.0

SECONDARY outcome

Timeframe: 24 hours postoperatively

Population: Patients who completed the study in one of the two groups

Count of the number of patients reporting nausea

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Patients Reporting Nausea	8 Participants	5 Participants

SECONDARY outcome

Timeframe: 24 hours postoperatively

Population: Patients who completed the study in one of the two groups

Count of the number of episodes of nausea per patient

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Episodes of Nausea	0.00 number of episodes per patient Interval 0.0 to 0.0	0.00 number of episodes per patient Interval 0.0 to 0.0

SECONDARY outcome

Timeframe: 2 hours postoperatively

Population: Patients who completed the study in one of the two groups

Count of the number of patients reporting vomiting

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Patients Reporting Vomiting	1 Participants	1 Participants

SECONDARY outcome

Timeframe: 2 hours postoperatively

Population: Patients who completed the study in one of the two groups

Count of the number of episodes of vomiting per patient

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Episodes of Vomiting	0.00 number of episodes per patient Interval 0.0 to 0.0	0.00 number of episodes per patient Interval 0.0 to 0.0

SECONDARY outcome

Timeframe: 24 hours postoperatively

Population: Patients who completed the study in one of the two groups

Count of the number of patients reporting vomiting

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Patients Reporting Vomiting	3 Participants	2 Participants

SECONDARY outcome

Timeframe: 24 hours postoperatively

Population: Patients who completed the study in one of the two groups

Count of the number of episodes of vomiting per patient

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Episodes of Vomiting	0.00 number of episodes per patient Interval 0.0 to 0.0	0.00 number of episodes per patient Interval 0.0 to 0.0

SECONDARY outcome

Timeframe: 2 hours postoperatively

Population: Patients who completed the study in one of the two groups

Measure of the amount of morphine milliequivalents consumed by the patient

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Total Opioid Consumption	19.50 milligram morphine equivalents Interval 8.0 to 30.0	30.00 milligram morphine equivalents Interval 15.0 to 32.0

SECONDARY outcome

Timeframe: 24 hours postoperatively

Population: Patients who completed the study in one of the two groups

Measure of the amount of morphine milliequivalents consumed by the patient

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Total Opioid Consumption	45.00 milligram morphine equivalents Interval 30.0 to 56.0	36.00 milligram morphine equivalents Interval 30.0 to 56.0

SECONDARY outcome

Timeframe: Up to 14 nights postoperatively

Population: Patients who completed the study in one of the two groups

Number of nights hospitalized

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Nights Hospitalized	1.00 nights Interval 1.0 to 1.0	1.00 nights Interval 1.0 to 1.0

SECONDARY outcome

Timeframe: Up to 336 hours postoperatively

Population: Patients who completed the study in one of the two groups

Number of hours hospitalized

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Hours Hospitalized	23.66 hours Interval 21.92 to 25.48	25.92 hours Interval 23.6 to 27.07

SECONDARY outcome

Timeframe: Up to 24 hours postoperatively

Population: Patients who completed the study in one of the two groups

The number of patients discharged home by midnight on postoperative day zero

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Discharges by Midnight POD0	3 Participants	4 Participants

SECONDARY outcome

Timeframe: Up to 48 hours postoperatively

Population: Patients who completed the study in one of the two groups

The number of patients discharged home by midnight postoperative day one

Outcome measures

Measure	Preoperative Adductor Canal Block Group n=46 Participants Participants in this group will receive the standard of care treatment for pain management for TKA including a preoperative adductor canal block. Participants will be in this group for up to 24 hours after surgery. Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.	Postoperative Adductor Canal Block Group n=37 Participants Participants in this group will receive the standard of care treatment for pain management after TKA, however, the adductor canal block will be placed postoperatively. Participants will be in this group for up to 24 hours Dexamethasone: Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling Acetaminophen: 1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively Lyrica: Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively Celebrex: 200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively Meloxicam: 30mg administered via IV once postoperatively within 24 hours for pain and swelling Oxycodone: 5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively Ropivacaine: 20 milliliters Ropivacaine 0.2% administered via injection perioperatively.
Discharges by Midnight on POD1	40 Participants	29 Participants

Adverse Events

Preoperative Adductor Canal Block Group

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Postoperative Adductor Canal Block Group

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Victor H. Hernandez

University of Miami

Phone: 305-243-4000

Email: vhh1@med.miami.edu

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place