Effect of Quadratus Lumborum Block With Compound Lidocaine and Esketamine on Pain After Colorectal Surgery

NCT ID: NCT05964985

Last Updated: 2023-07-28

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 160 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-08-06
• Study Completion Date: 2024-02-15

Brief Summary

Purpose:

To explore effects of ultrasound-guided quadratus lumborum block with compound lidocaine and esketamine on postoperative pain after colorectal surgery.

Detailed Description

Poor post-surgical pain control is a leading factor that hinders the physicalrehabilitation, and causes acute cognitive impairment and chronic painsyndrome. Recently, the multimodal analgesia strategies to minimise opioidrelated side effects are highly desirable in open surgical procedures. Quadratus lumborum block is a novel technique. Although ropivacaine is most commonly used forthis technique, the analgesic duration remains not dissatisfied. Compared with ropivacaine, compound lidocaine injection has a better and longer analgesic activity since it contains menthol and ethanol with appropriate concentrations. However, whether compound lidocaine injection is efficiency in the quadratus lumborum block for abdominal surgery lacks investigations. Herein, we will evaluate the efficacy of ultrasound-guided quadratus lumborum block (USG-QLB) with compound lidocaine injection and esketamine for postoperative analgesia in patients undergoing colorectal surgery.

Conditions

Postoperative Pain

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: DOUBLE

Study Groups

Normal saline in quadratus lumborum block

After the induction of anesthesia, normal saline is used for bilateral quadratus lumborum block in a volume of 20 mL of each side.

Group Type: PLACEBO_COMPARATOR

Normal saline

Intervention Type: DRUG

After the induction of anesthesia, normal saline is used for bilateral quadratus lumborum block in a volume of 20 mL of each side

Ropivacaine in quadratus lumborum block

After the induction of anesthesia, 0.375% ropivacaine is used for bilateral quadratus lumborum block in a volume of 20 mL of each side.

Group Type: ACTIVE_COMPARATOR

Ropivacaine

Intervention Type: DRUG

After the induction of anesthesia, 0.375% ropivacaine is used for bilateral quadratus lumborum block in a volume of 20 mL of each side

Compound lidocaine in quadratus lumborum block

After the induction of anesthesia, 0.6% compound lidocaine is used for bilateral quadratus lumborum block in a volume of 20 mL of each side.

Group Type: ACTIVE_COMPARATOR

Compound lidocaine

Intervention Type: DRUG

After the induction of anesthesia, 0.6% compound lidocaine is used for bilateral quadratus lumborum block in a volume of 20 mL of each side

Compound lidocaine and esketamine in quadratus lumborum block

After the induction of anesthesia, 0.6% compound lidocaine and 0.4 mg/kg esketamine are used for bilateral quadratus lumborum block in a volume of 20 mL of each side.

Group Type: ACTIVE_COMPARATOR

Compound lidocaine

Intervention Type: DRUG

After the induction of anesthesia, 0.6% compound lidocaine is used for bilateral quadratus lumborum block in a volume of 20 mL of each side

Esketamine

Intervention Type: DRUG

After the induction of anesthesia, 0.4mg/kg esketamine is used for bilateral quadratus lumborum block

Interventions

Normal saline

After the induction of anesthesia, normal saline is used for bilateral quadratus lumborum block in a volume of 20 mL of each side

Intervention Type: DRUG

Ropivacaine

After the induction of anesthesia, 0.375% ropivacaine is used for bilateral quadratus lumborum block in a volume of 20 mL of each side

Intervention Type: DRUG

Compound lidocaine

After the induction of anesthesia, 0.6% compound lidocaine is used for bilateral quadratus lumborum block in a volume of 20 mL of each side

Intervention Type: DRUG

Esketamine

After the induction of anesthesia, 0.4mg/kg esketamine is used for bilateral quadratus lumborum block

Intervention Type: DRUG

Other Intervention Names

0. 9% Sodium Chloride Injection; Ropivacaine Hydrochloride Injection; Compound Lidocaine Hydrochloride Injection; Esketamine injection

Eligibility Criteria

Inclusion Criteria

1. Subject is scheduled to undergo colorectal cancer surgery under general anesthesia

2. Subject's American Society of Anesthesiologists physical status is I-III.

3. The subject's parent/legally authorized guardian has given written informed consent to participate

Exclusion Criteria

1. Subject has a diagnosis of bronchial asthma, coronary heart disease, severe hypertension, renal failure or liver failure.

2. Subject has a diagnosis of Insulin dependent diabetes.

3. Subject is allergy and contraindication to local anesthetics or any components of local anesthetics.

4. Subject has a history of chronic pain, a history of alcohol or opioid abuse, pre- existing therapy with opioids, intake of any analgesic drug within 48 hours before surgery.

5. Subject has any contraindication for the use of patient-controlled analgesia (PCA).

6. Subject is pregnant or breast-feeding.

7. Subject is obese (body mass index >30kg/m^2).

8. Subject is incapacity to comprehend pain assessment and cognitive assessment.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tianjin Medical University General Hospital

OTHER

Sponsor Role: lead

Responsible Party

Guolin Wang

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Guolin Wang, MD

Role: STUDY_DIRECTOR

Tianjin Medical University General Hospital

Central Contacts

Guolin Wang, MD

Role: CONTACT

wangguolinghad@hotmail.com

+86 15822855556

Other Identifiers

GWang023

Identifier Type: -

Identifier Source: org_study_id