Trial Outcomes & Findings for A Chatbot Intervention for Reducing HPV Vaccine Hesitancy (NCT NCT05959564)
NCT ID: NCT05959564
Last Updated: 2024-10-21
Results Overview
Participants' attitudes toward HPV vaccination were measured by seven questions such as "The HPV vaccine is beneficial for adolescents." The responses were recorded on 1 (strongly disagree) to 5 (strongly agree) scales. Final score was the average of all 7 questions.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
456 participants
Primary outcome timeframe
baseline posttest (test took approximately 5 minutes to complete)
Results posted on
2024-10-21
Participant Flow
Participant milestones
| Measure |
Personalized Chatbot Condition
After reading a standard CDC HPV vaccine message, participants interacted with a chatbot designed to deliver personalized HPV vaccine messages (i.e., tailored to their personalities).
Personalized Chatbot Intervention: In this intervention, participants first saw a standard CDC HPV vaccine message. After that they were invited to interact with a chatbot designed to deliver additional HPV vaccine messages, which were tailored to their personalities.
|
Non-Personalized Chatbot Condition
After reading a standard CDC HPV vaccine message, participants interacted with a chatbot designed to deliver HPV vaccine messages, which were not tailored to their personalities.
Non-Personalized Chatbot Intervention: In this intervention, participants first saw a standard CDC HPV vaccine message. After that they were invited to interact with a chatbot designed to deliver additional HPV vaccine messages, which were not tailored to their personalities.
|
No Chatbot Control Condition
Participants read a standard CDC HPV vaccine message without interacting with any chatbot that delivers additional messages.
No Chatbot Control: In this intervention, participants saw a standard CDC HPV vaccine message only and did not interact with any chatbot.
|
|---|---|---|---|
|
Overall Study
STARTED
|
152
|
154
|
150
|
|
Overall Study
COMPLETED
|
152
|
154
|
150
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
A Chatbot Intervention for Reducing HPV Vaccine Hesitancy
Baseline characteristics by cohort
| Measure |
Personalized Chatbot Condition
n=152 Participants
After reading a standard CDC HPV vaccine message, participants interacted with a chatbot designed to deliver personalized HPV vaccine messages (i.e., tailored to their personalities).
Personalized Chatbot Intervention: In this intervention, participants first saw a standard CDC HPV vaccine message. After that they were invited to interact with a chatbot designed to deliver additional HPV vaccine messages, which were tailored to their personalities.
|
Non-Personalized Chatbot Condition
n=154 Participants
After reading a standard CDC HPV vaccine message, participants interacted with a chatbot designed to deliver HPV vaccine messages, which were not tailored to their personalities.
Non-Personalized Chatbot Intervention: In this intervention, participants first saw a standard CDC HPV vaccine message. After that they were invited to interact with a chatbot designed to deliver additional HPV vaccine messages, which were not tailored to their personalities.
|
No Chatbot Control Condition
n=150 Participants
Participants read a standard CDC HPV vaccine message without interacting with any chatbot that delivers additional messages.
No Chatbot Control: In this intervention, participants saw a standard CDC HPV vaccine message only and did not interact with any chatbot.
|
Total
n=456 Participants
Total of all reporting groups
|
|---|---|---|---|---|
|
Age, Continuous
|
41.16 years
STANDARD_DEVIATION 10.55 • n=5 Participants
|
37.80 years
STANDARD_DEVIATION 9.33 • n=7 Participants
|
40.98 years
STANDARD_DEVIATION 10.77 • n=5 Participants
|
39.96 years
STANDARD_DEVIATION 10.32 • n=4 Participants
|
|
Sex/Gender, Customized
Male
|
64 Participants
n=5 Participants
|
64 Participants
n=7 Participants
|
72 Participants
n=5 Participants
|
200 Participants
n=4 Participants
|
|
Sex/Gender, Customized
Female
|
87 Participants
n=5 Participants
|
87 Participants
n=7 Participants
|
77 Participants
n=5 Participants
|
251 Participants
n=4 Participants
|
|
Sex/Gender, Customized
Non-binary
|
1 Participants
n=5 Participants
|
3 Participants
n=7 Participants
|
1 Participants
n=5 Participants
|
5 Participants
n=4 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Race (NIH/OMB)
Asian
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Race (NIH/OMB)
Black or African American
|
152 Participants
n=5 Participants
|
154 Participants
n=7 Participants
|
150 Participants
n=5 Participants
|
456 Participants
n=4 Participants
|
|
Race (NIH/OMB)
White
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Race (NIH/OMB)
More than one race
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Education
Less than high school
|
1 Participants
n=5 Participants
|
1 Participants
n=7 Participants
|
1 Participants
n=5 Participants
|
3 Participants
n=4 Participants
|
|
Education
Some high school
|
0 Participants
n=5 Participants
|
2 Participants
n=7 Participants
|
1 Participants
n=5 Participants
|
3 Participants
n=4 Participants
|
|
Education
High school graduate
|
14 Participants
n=5 Participants
|
12 Participants
n=7 Participants
|
13 Participants
n=5 Participants
|
39 Participants
n=4 Participants
|
|
Education
Some college
|
49 Participants
n=5 Participants
|
49 Participants
n=7 Participants
|
33 Participants
n=5 Participants
|
131 Participants
n=4 Participants
|
|
Education
College graduate
|
70 Participants
n=5 Participants
|
68 Participants
n=7 Participants
|
81 Participants
n=5 Participants
|
219 Participants
n=4 Participants
|
|
Education
Post-college
|
18 Participants
n=5 Participants
|
22 Participants
n=7 Participants
|
21 Participants
n=5 Participants
|
61 Participants
n=4 Participants
|
PRIMARY outcome
Timeframe: baseline posttest (test took approximately 5 minutes to complete)Participants' attitudes toward HPV vaccination were measured by seven questions such as "The HPV vaccine is beneficial for adolescents." The responses were recorded on 1 (strongly disagree) to 5 (strongly agree) scales. Final score was the average of all 7 questions.
Outcome measures
| Measure |
Personalized Chatbot Condition
n=152 Participants
After reading a standard CDC HPV vaccine message, participants interacted with a chatbot designed to deliver personalized HPV vaccine messages (i.e., tailored to their personalities).
Personalized Chatbot Intervention: In this intervention, participants first saw a standard CDC HPV vaccine message. After that they were invited to interact with a chatbot designed to deliver additional HPV vaccine messages, which were tailored to their personalities.
|
Non-Personalized Chatbot Condition
n=154 Participants
After reading a standard CDC HPV vaccine message, participants interacted with a chatbot designed to deliver HPV vaccine messages, which were not tailored to their personalities.
Non-Personalized Chatbot Intervention: In this intervention, participants first saw a standard CDC HPV vaccine message. After that they were invited to interact with a chatbot designed to deliver additional HPV vaccine messages, which were not tailored to their personalities.
|
No Chatbot Control Condition
n=150 Participants
Participants read a standard CDC HPV vaccine message without interacting with any chatbot that delivers additional messages.
No Chatbot Control: In this intervention, participants saw a standard CDC HPV vaccine message only and did not interact with any chatbot.
|
|---|---|---|---|
|
Attitudes Toward HPV Vaccination
|
3.86 score on a scale
Standard Deviation .84
|
3.96 score on a scale
Standard Deviation .86
|
3.41 score on a scale
Standard Deviation .85
|
PRIMARY outcome
Timeframe: baseline posttest (test took approximately 5 minutes to complete)Participants' intentions toward vaccinating their children against HPV were measured by three questions such as "I am likely to get my child/children the HPV vaccine." Responses were indicated on 1 (strongly disagree) to 5 (strongly agree) scales. The final score was the average of the three questions.
Outcome measures
| Measure |
Personalized Chatbot Condition
n=152 Participants
After reading a standard CDC HPV vaccine message, participants interacted with a chatbot designed to deliver personalized HPV vaccine messages (i.e., tailored to their personalities).
Personalized Chatbot Intervention: In this intervention, participants first saw a standard CDC HPV vaccine message. After that they were invited to interact with a chatbot designed to deliver additional HPV vaccine messages, which were tailored to their personalities.
|
Non-Personalized Chatbot Condition
n=154 Participants
After reading a standard CDC HPV vaccine message, participants interacted with a chatbot designed to deliver HPV vaccine messages, which were not tailored to their personalities.
Non-Personalized Chatbot Intervention: In this intervention, participants first saw a standard CDC HPV vaccine message. After that they were invited to interact with a chatbot designed to deliver additional HPV vaccine messages, which were not tailored to their personalities.
|
No Chatbot Control Condition
n=150 Participants
Participants read a standard CDC HPV vaccine message without interacting with any chatbot that delivers additional messages.
No Chatbot Control: In this intervention, participants saw a standard CDC HPV vaccine message only and did not interact with any chatbot.
|
|---|---|---|---|
|
Intentions Toward HPV Vaccination
|
3.87 score on a scale
Standard Deviation 1.17
|
3.95 score on a scale
Standard Deviation 1.08
|
3.56 score on a scale
Standard Deviation 1.18
|
SECONDARY outcome
Timeframe: baseline posttest (test took approximately 5 minutes to complete)Population: participants in the no chatbot control condition were not asked to rate the chatbot.
Ratings of the Chatbot were measured by nine questions such as "How would you describe the HPV chatbot you just interacted with? - Engaging" on 1 (strongly disagree) to 5 (strongly agree) scales. The final score was the average of the nine questions.
Outcome measures
| Measure |
Personalized Chatbot Condition
n=130 Participants
After reading a standard CDC HPV vaccine message, participants interacted with a chatbot designed to deliver personalized HPV vaccine messages (i.e., tailored to their personalities).
Personalized Chatbot Intervention: In this intervention, participants first saw a standard CDC HPV vaccine message. After that they were invited to interact with a chatbot designed to deliver additional HPV vaccine messages, which were tailored to their personalities.
|
Non-Personalized Chatbot Condition
n=130 Participants
After reading a standard CDC HPV vaccine message, participants interacted with a chatbot designed to deliver HPV vaccine messages, which were not tailored to their personalities.
Non-Personalized Chatbot Intervention: In this intervention, participants first saw a standard CDC HPV vaccine message. After that they were invited to interact with a chatbot designed to deliver additional HPV vaccine messages, which were not tailored to their personalities.
|
No Chatbot Control Condition
Participants read a standard CDC HPV vaccine message without interacting with any chatbot that delivers additional messages.
No Chatbot Control: In this intervention, participants saw a standard CDC HPV vaccine message only and did not interact with any chatbot.
|
|---|---|---|---|
|
Ratings of the Chatbot
|
4.10 score on a scale
Standard Deviation .79
|
4.16 score on a scale
Standard Deviation .70
|
—
|
Adverse Events
Personalized Chatbot Condition
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Non-Personalized Chatbot Condition
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
No Chatbot Control Condition
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place