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The Comparison of Handgrip Strength, Lean Mass, and Blood Pressure in Primary School Children Aged 8-10 Years Old With Undernutrition and Normal Nutritional Status

NCT ID: NCT05952479

Last Updated: 2023-11-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

75 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-10-01

Study Completion Date

2024-08-31

Brief Summary

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Undernutrition occurs in 900 million individuals globally, so it is a very important health problem because it contributes to high mortality rates, especially in children. In addition, undernutrition has consequences for children's growth and development, including increased susceptibility to 1) Experiencing fat accumulation, especially in the central part of the body; 2) Experiencing changes in body metabolism, especially fat, decreased oxidation; 3) Experiencing a decrease in resting energy expenditure and postprandial energy expenditure; 4) Insulin resistance in adulthood which results in hypertension and dyslipidemia, 5) Decreased capacity to do manual work that requires physical strength. 6) Changes occur in the function of the autonomic nervous system (Matrins et al., 2011). Loss of muscle mass and function causes muscle weakness. Handgrip strength has been used as a tool to measure muscle strength and functionality and can measure low individual mobility because handgrip strength is positively correlated with daily activity (Whiting et al., 2016). Hand grip strength or handgrip strength is used as a predictor of undernutrition in adult patients with cancer who are hospitalized (Bauer et al., 2015), and is stated as a predictor of nutritional status and changes in nutritional status (Flood et al., 2014). Other research also shows that there is a positive correlation between BMI percentile and hand grip strength (Kotecha and Desai, 2022). In studies on elderly populations, handgrip strength is positively correlated with nutritional status (Akbar and Setiati, 2018), while in populations of children at risk of malnutrition (using the Paediatric Yorkhill Malnutrition Score-PYM), it shows handgrip strength based on age (HGS z-score). and based on height is lower than children who have a lower risk of malnutrition. The HGS z-score can also be used as a predictor of fat free mass (FFM) for sick children compared to healthy children and is also related to plasma CRP (Mckirdy et al., 2021).

Based on the explanation above, this research was conducted to know the differences in hand grip strength, muscle mass, and blood pressure in undernourished children aged 8-10 years compared to normal children.

Detailed Description

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An experimental study with an analytic cross-sectional design examines muscle mass, hand grip strength, and blood pressure in children with undernutrition compared to normal. The subjects are elementary school children aged 8-10 years with undernutrition and overnutrition. Undernutrition was determined after measuring body weight and height, then weight/age, height/age, and weight/height z-scores were determined using the WHO Anthroplus software. If \< -2 SD, then grouped into undernutrition, but if 0 to -2 SD then grouped into normal. Homogeneity and normality tests were carried out on the variables age, weight, height, anthropometry, arm and waist circumference, hand grip strength, muscle mass, and blood pressure. Data is presented in descriptive form (x + SD). A paired sample t-test (or Mann-Whitney test) was performed on these variables, dividing the subjects into 2: undernutrition vs. normal, with significance \>0.05. Relationships between variables were analyzed using Pearson's or Spearman's correlation.

1. After obtaining permission and approval from the school, the researcher conducted an initial screening by measuring height and weight, as well as the age of the prospective subject/
2. Determination of nutritional status using WHO Anthroplus to determine undernourished and normal nutritional subjects
3. Furthermore, the researchers reported the findings to the school for socialization and the signing of informed consent by parents
4. Researchers re-measurement of weight, height, waist circumference, blood pressure and handgrip strength in subjects who are willing to take part in the study.

Conditions

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Undernutrition

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Undernutrition

Undernutrition is defined as weight-for-age z-score (WAZ), height-for-age z-score (HAZ), and weight-for-height z-score (WHZ) of WHO growth chart standards \< -2.00 SD

No interventions assigned to this group

Normal nutrition

Normal nutrition is defined as weight-for-age z-score (WAZ), height-for-age z-score (HAZ), and weight-for-height z-score (WHZ) of WHO growth chart standards in the range of +2 and -2.00 SD

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Children aged 8 years until 10 years
* Study in Primary School in Surabaya
* Healthy
* Volunteer to participate in this study (the parents sign the informed consent we sent)

Exclusion Criteria

* Had autoimmune disease, congenital disorders, or other chronical disease
* Retire during the observational periods
* Consumed steroids, antibiotics or hormone therapy
Minimum Eligible Age

8 Years

Maximum Eligible Age

10 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Indonesia University

OTHER

Sponsor Role collaborator

Gadjah Mada University

OTHER

Sponsor Role collaborator

Lembaga Pengelola Dana Pendidikan (Indonesia Endowment Fund for Education)

UNKNOWN

Sponsor Role collaborator

Universitas Airlangga

OTHER

Sponsor Role lead

Responsible Party

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Nur Aisiyah Widjaja

Principal Investigator and Medical Staf in Pediatric Nutrition and Metabolic Disease

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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SDN Airlangga III

Surabaya, East Java, Indonesia

Site Status RECRUITING

Countries

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Indonesia

Central Contacts

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Nur Aisiyah Widjaja, Doctor

Role: CONTACT

[email protected]
+628123073379

Soebagijo Adi Soelistijo, Internal specialist

Role: CONTACT

[email protected]
+628123531065

Other Identifiers

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Third ID

Identifier Type: -

Identifier Source: org_study_id