Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
45 participants
INTERVENTIONAL
2023-07-11
2024-07-31
Brief Summary
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How does avocado consumption affect the gut microbiome? How does avocado consumption affect thinking? Are there connections between the microbiome and cognition? Participants will be asked to eat provided meals with and without avocados for three 4-week periods. At the end of each 4-week period, participants will be asked to provide stool samples and complete computer games that assess thinking and memory.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Avocado
The experimental treatment will contain an avocado. Avocados will be consumed daily for 4 weeks.
Avocado
The intervention treatment will contain avocado
Fiber + Oil
The active comparator will have a snack that mimics the fiber and fatty acid composition found in avocados and will be consumed daily for 4 weeks.
Oil + Fiber
The active comparator will contain a snack with oils and fibers that mimic an avocado
Standard American Diet
The sham comparator contains foods and beverages of a standard American diet and will be consumed daily for 4 weeks.
Average American Diet
The sham comparator will contain foods/beverages that mimic a standard American Diet
Interventions
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Avocado
The intervention treatment will contain avocado
Oil + Fiber
The active comparator will contain a snack with oils and fibers that mimic an avocado
Average American Diet
The sham comparator will contain foods/beverages that mimic a standard American Diet
Eligibility Criteria
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Inclusion Criteria
* BMI ≥ 25 kg/m2
* Ability to drop off fecal sample within 15 minutes of defecation
* 20/20 or corrected vision
Exclusion Criteria
* Food allergies or intolerances
* Prior diagnosis of liver or gastrointestinal disease (primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), diabetes, hepatitis, HIV, or cancer
* Women that are pregnant, have given birth in the previous 12 months or are lactating
* Individuals that smoke, use tobacco, abuse drugs, or consume \> 2 alcoholic beverages per day.
* \> 5% weight change in the past month or \> 10% change in the past six months
* Oral antibiotics during the previous 6 weeks.
* Currently taking lipid-lowering medications, oral hypoglycemic agents, or insulin.
* History of malabsorptive or restrictive bariatric surgeries (e.g., gastric bypass, sleeve gastrectomy, adjustable gastric band) or gall bladder removal surgery.
* Are unable to consume the experimental meals/snacks.
* Allergic to latex
* Concurrent enrollment in another dietary, exercise, or medication study
25 Years
74 Years
ALL
Yes
Sponsors
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University of Illinois at Urbana-Champaign
OTHER
Responsible Party
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Hannah Holscher
Associate Professor
Principal Investigators
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Hannah Holscher, PhD, RD
Role: PRINCIPAL_INVESTIGATOR
University of Illinois Urbana Champaign
Locations
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University of Illinois, Urbana Champaign
Urbana, Illinois, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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22788
Identifier Type: -
Identifier Source: org_study_id
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