Trial Outcomes & Findings for ABSORB (Amount of Blueberries So Older Adults Reap Benefits) (NCT NCT05937165)
NCT ID: NCT05937165
Last Updated: 2025-12-15
Results Overview
Change in total flavonoid metabolites found in the urine. The values for the metabolites represent the relative abundance of each metabolite, rather than absolute quantification, with higher values reflecting higher levels of total flavonoid metabolites in the urine.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
6 participants
Primary outcome timeframe
Baseline and Day 3 of intervention
Results posted on
2025-12-15
Participant Flow
Participant milestones
| Measure |
Freeze-dried Blueberry Powder (Standard Dose Then Higher Dose)
Consumption of 24 g of freeze dried blueberry powder for 3 consecutive days and then consumption of 48 g of freeze dried blueberry powder for 3 consecutive days, separated by a washout.
|
Freeze-dried Blueberry Powder (Higher Dose Then Standard Dose)
Consumption of 48 g of freeze dried blueberry powder for 3 consecutive days and then consumption of 24 g of freeze dried blueberry powder for 3 consecutive days, separated by a washout.
|
|---|---|---|
|
Overall Study
STARTED
|
3
|
3
|
|
Overall Study
COMPLETED
|
3
|
2
|
|
Overall Study
NOT COMPLETED
|
0
|
1
|
Reasons for withdrawal
| Measure |
Freeze-dried Blueberry Powder (Standard Dose Then Higher Dose)
Consumption of 24 g of freeze dried blueberry powder for 3 consecutive days and then consumption of 48 g of freeze dried blueberry powder for 3 consecutive days, separated by a washout.
|
Freeze-dried Blueberry Powder (Higher Dose Then Standard Dose)
Consumption of 48 g of freeze dried blueberry powder for 3 consecutive days and then consumption of 24 g of freeze dried blueberry powder for 3 consecutive days, separated by a washout.
|
|---|---|---|
|
Overall Study
Withdrawal by Subject
|
0
|
1
|
Baseline Characteristics
ABSORB (Amount of Blueberries So Older Adults Reap Benefits)
Baseline characteristics by cohort
| Measure |
Freeze-dried Blueberry Powder (Standard Dose Then Higher Dose)
n=3 Participants
Consumption of 24 g of freeze dried blueberry powder for 3 consecutive days and then consumption of 48 g of freeze dried blueberry powder for 3 consecutive days, separated by a washout.
|
Freeze-dried Blueberry Powder (Higher Dose Then Standard Dose)
n=3 Participants
Consumption of 48 g of freeze dried blueberry powder for 3 consecutive days and then consumption of 24 g of freeze dried blueberry powder for 3 consecutive days, separated by a washout.
|
Total
n=6 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Race (NIH/OMB)
White
|
3 Participants
n=6009 Participants
|
3 Participants
n=42 Participants
|
6 Participants
n=77 Participants
|
|
Age, Continuous
|
69 years
STANDARD_DEVIATION 4 • n=6009 Participants
|
76 years
STANDARD_DEVIATION 5 • n=42 Participants
|
73 years
STANDARD_DEVIATION 5 • n=77 Participants
|
|
Sex: Female, Male
Female
|
2 Participants
n=6009 Participants
|
3 Participants
n=42 Participants
|
5 Participants
n=77 Participants
|
|
Sex: Female, Male
Male
|
1 Participants
n=6009 Participants
|
0 Participants
n=42 Participants
|
1 Participants
n=77 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=6009 Participants
|
0 Participants
n=42 Participants
|
0 Participants
n=77 Participants
|
|
Race (NIH/OMB)
Asian
|
0 Participants
n=6009 Participants
|
0 Participants
n=42 Participants
|
0 Participants
n=77 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=6009 Participants
|
0 Participants
n=42 Participants
|
0 Participants
n=77 Participants
|
|
Race (NIH/OMB)
Black or African American
|
0 Participants
n=6009 Participants
|
0 Participants
n=42 Participants
|
0 Participants
n=77 Participants
|
|
Race (NIH/OMB)
More than one race
|
0 Participants
n=6009 Participants
|
0 Participants
n=42 Participants
|
0 Participants
n=77 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=6009 Participants
|
0 Participants
n=42 Participants
|
0 Participants
n=77 Participants
|
|
Region of Enrollment
United States
|
3 Participants
n=6009 Participants
|
3 Participants
n=42 Participants
|
6 Participants
n=77 Participants
|
|
Depressive Symptom Severity
|
3.0 points
STANDARD_DEVIATION 2.0 • n=6009 Participants
|
4.3 points
STANDARD_DEVIATION 3.1 • n=42 Participants
|
3.7 points
STANDARD_DEVIATION 2.4 • n=77 Participants
|
PRIMARY outcome
Timeframe: Baseline and Day 3 of interventionChange in total flavonoid metabolites found in the urine. The values for the metabolites represent the relative abundance of each metabolite, rather than absolute quantification, with higher values reflecting higher levels of total flavonoid metabolites in the urine.
Outcome measures
| Measure |
Standard Dose Freeze-dried Blueberry Powder
n=5 Participants
Consumption of 24 g of freeze dried blueberry powder for 3 consecutive days.
|
Higher Dose Freeze-dried Blueberry Powder
n=5 Participants
Consumption of 48 g of freeze dried blueberry powder for 3 consecutive days.
|
|---|---|---|
|
Urinary Flavonoid Biomarkers
|
398863 Unitless
Standard Deviation 274183
|
1045795 Unitless
Standard Deviation 661053
|
PRIMARY outcome
Timeframe: Baseline and Day 3 of interventionChange in serum C-reactive Protein
Outcome measures
| Measure |
Standard Dose Freeze-dried Blueberry Powder
n=5 Participants
Consumption of 24 g of freeze dried blueberry powder for 3 consecutive days.
|
Higher Dose Freeze-dried Blueberry Powder
n=6 Participants
Consumption of 48 g of freeze dried blueberry powder for 3 consecutive days.
|
|---|---|---|
|
Inflammatory Biomarker C-reactive Protein
|
-100 nanograms/mL
Standard Deviation 642
|
-635 nanograms/mL
Standard Deviation 1318
|
SECONDARY outcome
Timeframe: Baseline and Day 3 of interventionChange in tumor necrosis factor alpha
Outcome measures
| Measure |
Standard Dose Freeze-dried Blueberry Powder
n=5 Participants
Consumption of 24 g of freeze dried blueberry powder for 3 consecutive days.
|
Higher Dose Freeze-dried Blueberry Powder
n=6 Participants
Consumption of 48 g of freeze dried blueberry powder for 3 consecutive days.
|
|---|---|---|
|
Inflammatory Biomarker Tumor Necrosis Factor Alpha
|
-0.03 picograms/mL
Standard Deviation 0.11
|
0.06 picograms/mL
Standard Deviation 0.08
|
SECONDARY outcome
Timeframe: Baseline and Day 3 of interventionChange in interleukin 6
Outcome measures
| Measure |
Standard Dose Freeze-dried Blueberry Powder
n=5 Participants
Consumption of 24 g of freeze dried blueberry powder for 3 consecutive days.
|
Higher Dose Freeze-dried Blueberry Powder
n=6 Participants
Consumption of 48 g of freeze dried blueberry powder for 3 consecutive days.
|
|---|---|---|
|
Inflammatory Biomarker Interleukin 6
|
0.28 picograms/mL
Standard Deviation 0.55
|
-1.3 picograms/mL
Standard Deviation 3.0
|
SECONDARY outcome
Timeframe: Baseline and Day 3 of interventionChange in serum interferon gamma
Outcome measures
Outcome data not reported
Adverse Events
Standard Dose of Freeze-dried Blueberry Powder
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Higher Dose of Freeze-dried Blueberry Powder
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Courtney Millar
Hebrew SeniorLife, Marcus Institute of Aging, Harvard Medical School
Phone: 6179715531
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place