Fiber's Utilization for Energy and Life

NCT ID: NCT05934357

Last Updated: 2023-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

19 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-05-13

Study Completion Date

2024-05-31

Brief Summary

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The study aims to evaluate the metabolizable energy of the typical American diet with and without the inclusion of fiber. We hypothesize that including fiber in the diet will decrease the metabolizable energy of the diet resulting in more nutrient loss into the feces and urine.

Detailed Description

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The study will be a randomized, crossover, controlled feeding trial comprised of 2 experimental periods: 1) control and 2) fiber. Each experimental condition will be 16 days in length. There will be at least a 12-day compliance break between each period. Participants will undergo complete urine and fecal collection for a period five to seven days during the second half of each experimental condition.

Conditions

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Diet Habit

Keywords

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Fiber Metabolizable Energy Gastrointestinal Microbiota

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Intervention Treatment

Experimental treatment will contain a cereal product that contains a dietary fiber. This will be consumed three times daily for two weeks.

Group Type EXPERIMENTAL

Fiber

Intervention Type OTHER

The intervention treatment will contain fiber.

Control treatment

Control treatment will contain a corn meal cereal product that will be consumed three times daily for two weeks.

Group Type PLACEBO_COMPARATOR

Control

Intervention Type OTHER

The control treatment will contain corn meal.

Interventions

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Fiber

The intervention treatment will contain fiber.

Intervention Type OTHER

Control

The control treatment will contain corn meal.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adults ages 22-75 years
* BMI between 18.5 and 39.9 kg/m2
* Ability to drop-off 1 fecal sample within 15 minutes of defecation
* Ability to pick-up meals daily
* Ability to collect fecal and urine samples daily
* Fasting glucose of \<126 mg/dL

Exclusion Criteria

* Wheat allergy or intolerance
* Any food allergies or intolerances
* Prior diagnosis of metabolic or gastrointestinal disease (kidney disease, liver disease, gout, hyperthyroidism, untreated or unstable hypothyroidism, certain cancers, gastrointestinal disease, pancreatic disease, diabetes requiring medication)
* Women that are pregnant, had a baby within the last 12 months, or are lactating.
* Individuals that smoke, use tobacco, abuse drugs, or consume \> 2 alcoholic beverages per day.
* \>5% weight change in the past month or \>10% change in the past year
* Oral antibiotics during the previous 6 weeks
* History of malabsorptive or restrictive bariatric surgeries (e.g., gastric bypass, sleeve gastrectomy, adjustable gastric band) or gall bladder removal surgery
* Are unable or unwilling to consume the experimental meals/snacks.
* Taking certain medications (Orlistat, bile binding resins, insulin, oral hypoglycemic agents, laxatives)
* Concurrent enrollment in another dietary, exercise, or medication study
Minimum Eligible Age

22 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Illinois at Urbana-Champaign

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Edward R Madigan Laboratory

Urbana, Illinois, United States

Site Status

Countries

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United States

Other Identifiers

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24042

Identifier Type: -

Identifier Source: org_study_id