A Study to Evaluate the Immunogenicity and Safety of A Recombinant Protein COVID-19 Vaccine as Booster Vaccines

NCT ID: NCT05933512

Last Updated: 2023-07-06

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 600 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-08-10
• Study Completion Date: 2024-11-10

Brief Summary

This study is a phase Ⅱ clinical trial to evaluate the safety and immunogenicity of SCTV01E-2 in people of different ages who had been vaccinated with COVID-19 vaccines. A total of at least 600 subjects aged 3 years and older who were previously vaccinated with domestically licensed SARS-CoV-2 vaccines with recommended doses and immunization schedules are planned to be enrolled. Group A included 400 patients aged 18 years and above, and group B included 200 patients aged 3-17 years.

Detailed Description

For participants in Group A, they will be randomized to receive SCTV01E or SCTV01E-2 in a ratio of 1:1. For participants in Group B, they will all receive SCTV01E-2.

Conditions

COVID-19; SARS-CoV-2 Infection

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: QUADRUPLE

Study Groups

Group A:SCTV01E-2

one dose of SCTV01E-2 on D0

Group Type: EXPERIMENTAL

SCTV01E-2

Intervention Type: BIOLOGICAL

intramuscular injection

Group A:SCTV01E

one dose of SCTV01E on D0

Group Type: ACTIVE_COMPARATOR

SCTV01E

Intervention Type: BIOLOGICAL

intramuscular injection

Group B:SCTV01E-2

one dose of SCTV01E-2 on D0

Group Type: EXPERIMENTAL

SCTV01E-2

Intervention Type: BIOLOGICAL

intramuscular injection

Interventions

SCTV01E-2

intramuscular injection

Intervention Type: BIOLOGICAL

SCTV01E

intramuscular injection

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

• 1. Aged ≥3 years old when signing ICF;
• 2. Participants who were vaccinated with licenced COVID-19 vaccines with recommended doses and immune schedule, and the interval between the last dose and ICF is ≥6 months.
• 3. The participant and/or his/her legal guardians or entrusted person can sign the written ICF, and can fully understand the trial procedure, the risk of participating in the trial, and other interventions that can be selected if they do not participate in the trial;
• 4. The participant and/or his/her legal guardians or entrusted person have the ability to read, understand, and fill in record cards;
• 5. Healthy participants or participants with pre-existing medical conditions who are in stable condition. A stable medical condition is defined as disease not requiring significant change in therapy or no need for hospitalization as a consequence of worsening disease state for at least 3 months prior to enrollment;
• 6. Fertile men and women of childbearing potential voluntarily agree to take effective contraceptive measures from signing ICF to 6 months after the study vaccination; the pregnancy test results of women of childbearing potential are negative on screening.

Exclusion Criteria

• 1. Presence of fever within 72 hours before the study vaccination (for participants >14 years old, axillary temperature ≥37.3℃; for participants ≤14 years old, axillary temperature ≥37.5℃;);
• 2. A positive result of antigen test or nucleic acid test for SARS-CoV-2 during the screening period;
• 3. A positive result of SARS-CoV-2 IgM test;
• 4. Known history of SARS-CoV-2 infection within 6 months before ICF;
• 5. A history of sereve allergic reactions such as severe skin eczema, dyspnea, laryngeal edema, and angioneurotic edema, or allergic reactions to the study vaccines and its ingredient;
• 6. A medical or family history of seizure, epilepsy and psychosis;
• 7. Participants who is at the acute state of disease, such as acute onset of chronic heart failure, acute sore throat, hypertensive encephalopathy, acute pneumonia, acute renal insufficiency, acute cholecystitis;
• 8. Contraindications for intramuscular injection or intravenous blood sampling, including thrombocytopenia and other blood coagulation disorders;
• 9. Patients on antituberculosis therapy;
• 10. Participants vaccinated with influenza vaccine within 14 days or with other vaccines within 28 days before the study vaccination;
• 11. Participants who received other investigational drugs within 1 month before the study vaccination;
• 12. Participants who received any immunoglobulin or blood products in the previous 3 months before enrollment, or plan to receive similar products during the study;
• 13. Those who donated blood or had blood loss (≥450 mL) within 3 months before the vaccination or plan to donate blood during the study period;
• 14. Those who are pregnant or breast-feeding or plan to be pregnant during the study period;
• 15. Those who plan to donate ovum or sperms during the study period;
• 16. Those who cannot follow the trial procedures, or cannot cooperate to complete the study due to planned relocation or long-term outing;
• 17. Those unsuitable for participating in the clinical trial as determined by the investigator because of other abnormalities that are likely to confuse the study results, or non-conformance with the maximal benefits of the participants.

• Minimum Eligible Age: 3 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Sinocelltech Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Central Contacts

Xuxin Tian

Role: CONTACT

xuxin_tian@sinocelltech.com

+86 10 58628288

Wei Li

Role: CONTACT

wei_li@sinocelltech.com

+86 10 58628288

Other Identifiers

SCTV01E-2-CHN-1

Identifier Type: -

Identifier Source: org_study_id