Trial Outcomes & Findings for Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0 (NCT NCT05932693)

Last Updated: 2026-01-22

Results Overview

Difference in overall flavor intensity, coolness, sweetness and harshness/irritation at each e-cigarette condition as measured by the computerized Generalized Labeled Magnitude Scale (gLMS). Participants will self-report their responses using a computer mouse to indicate where on the scale response falls. The Generalized Labeled Magnitude Scales (gLMS) are category ratio scales with seven semantic labels: "no sensation", "barely detectable", "weak", "moderate", "strong", "very strong", and "strongest imaginable", positioned quasi-logarithmically as per empirically determined semantic magnitudes on a 0-100 scale (strongest imaginable at the 100 end).

Recruitment status

COMPLETED

Study phase

Target enrollment

31 participants

Primary outcome timeframe

Following administration of e-cigarette condition 1 (at 10 minutes), then 5 minutes post administration of each e-cigarette condition, up to 85 minutes (condition 16)

Results posted on

2026-01-22

Participant Flow

Participants were recruited from the local community and university settings using flyers, email advertisements, and online postings. Individuals who expressed interest were screened for eligibility and checked during intakes, and those meeting inclusion criteria were scheduled for a single laboratory session. A total of 31 eligible participants were enrolled, and 30 completed the study procedures, 27 were analyzed

Prior to completion of the lab session, one participant did not attend (due to no-show) and was therefore excluded from the final dataset. A total of 30 participants completed the laboratory procedures and were assigned to the study conditions.

Participant milestones

Participant milestones
Measure	A Single Lab Session With 16 Conditions/Exposures Participants attended a lab session that included 16 conditions/exposures involving WS-3, WS-23, and menthol. The three types of coolants were presented in randomized blocks, with each block containing increasing concentrations. The specific 16 conditions are listed below: WS-3 block (1): 0.05%, no nicotine; WS-3 block (2): 0.1%, no nicotine; WS-3 block (3): 0.5%, no nicotine; WS-3 block (4): 1.0%, no nicotine; WS-3 block (5): 2.0%, no nicotine; Menthol block (1): 0.05%, no nicotine; Menthol block (2): 0.1%, no nicotine; Menthol block (3): 0.5%, no nicotine; Menthol block (4): 1.0%, no nicotine; Menthol block (5): 2.0%, no nicotine; WS-23 block (1): 0.05%, no nicotine; WS-23 block (2): 0.1%, no nicotine; WS-23 block (3): 0.5%, no nicotine; WS-23 block (4): 1.0%, no nicotine; WS-23 block (5): 2.0%, no nicotine; WS-23 block (6): 4.0%, no nicotine
Overall Study STARTED	31
Overall Study WS-3 block (1): 0.05%, no nicotine	30
Overall Study WS-3 block (2): 0.1%, no nicotine	30
Overall Study WS-3 block (3): 0.5%, no nicotine	30
Overall Study WS-3 block (4): 1.0%, no nicotine	30
Overall Study WS-3 block (5): 2.0%, no nicotine	30
Overall Study Menthol block (1): 0.05%, no nicotine	30
Overall Study Menthol block (2): 0.1%, no nicotine	30
Overall Study Menthol block (3): 0.5%, no nicotine	30
Overall Study Menthol block (4): 1.0%, no nicotine	30
Overall Study Menthol block (5): 2.0%, no nicotine	30
Overall Study WS-23 block (1): 0.05%, no nicotine	30
Overall Study WS-23 block (2): 0.1%, no nicotine	30
Overall Study WS-23 block (3): 0.5%, no nicotine	30
Overall Study WS-23 block (4): 1.0%, no nicotine	30
Overall Study WS-23 block (5): 2.0%, no nicotine	30
Overall Study WS-23 block (6): 4.0%, no nicotine	30
Overall Study COMPLETED	30
Overall Study NOT COMPLETED	1

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	A Single Lab Session With 16 Conditions/Exposures n=31 Participants Participants attended a lab session that included 16 conditions/exposures involving WS-3, WS-23, and menthol. The three types of coolants were presented in randomized blocks, with each block containing increasing concentrations. The specific 16 conditions are listed below: WS-3 block (1): 0.05%, no nicotine; WS-3 block (2): 0.1%, no nicotine; WS-3 block (3): 0.5%, no nicotine; WS-3 block (4): 1.0%, no nicotine; WS-3 block (5): 2.0%, no nicotine; Menthol block (1): 0.05%, no nicotine; Menthol block (2): 0.1%, no nicotine; Menthol block (3): 0.5%, no nicotine; Menthol block (4): 1.0%, no nicotine; Menthol block (5): 2.0%, no nicotine; WS-23 block (1): 0.05%, no nicotine; WS-23 block (2): 0.1%, no nicotine; WS-23 block (3): 0.5%, no nicotine; WS-23 block (4): 1.0%, no nicotine; WS-23 block (5): 2.0%, no nicotine; WS-23 block (6): 4.0%, no nicotine
Age, Continuous	33.8 years old STANDARD_DEVIATION 9.7 • n=270 Participants
Sex: Female, Male Female	13 Participants n=270 Participants
Sex: Female, Male Male	18 Participants n=270 Participants
Race/Ethnicity, Customized Non-Hispanic White	16 Participants n=270 Participants
Race/Ethnicity, Customized Non-Hispanic Black	7 Participants n=270 Participants
Race/Ethnicity, Customized Non-Hispanic Asian	4 Participants n=270 Participants
Race/Ethnicity, Customized Hispanic or Latino	3 Participants n=270 Participants
Race/Ethnicity, Customized Others	1 Participants n=270 Participants
E-cigarette use frequency	26.0 days STANDARD_DEVIATION 3.6 • n=270 Participants

PRIMARY outcome

Timeframe: Following administration of e-cigarette condition 1 (at 10 minutes), then 5 minutes post administration of each e-cigarette condition, up to 85 minutes (condition 16)

Outcome measures

Outcome measures
Measure	WS-3 (1), 0.05% n=27 Participants WS-3 block: 0.05%, no nicotine	WS-3 (2), 0.1% n=27 Participants WS-3 block: 0.1%, no nicotine	WS-3 (3), 0.5% n=27 Participants WS-3 block: 0.5%, no nicotine	WS-3 (4), 1.0% n=27 Participants WS-3 block: 1.0%, no nicotine	WS-3 (5), 2.0% n=27 Participants WS-3 block: 2.0%, no nicotine	Menthol (1), 0.05% n=27 Participants Menthol block: 0.05%, no nicotine	Menthol (2), 0.1% n=27 Participants Menthol block: 0.1%, no nicotine	Menthol (3), 0.5% n=27 Participants Menthol block: 0.5%, no nicotine	Menthol (4), 1.0% n=27 Participants Menthol block: 1.0%, no nicotine	Menthol (5), 2.0% n=27 Participants Menthol block: 2.0%, no nicotine	WS-23 (1), 0.05% n=27 Participants WS-23 block: 0.05%, no nicotine	WS-23 (2), 0.1% n=27 Participants WS-23 block: 0.1%, no nicotine	WS-23 (3), 0.5% n=27 Participants WS-23 block: 0.5%, no nicotine	WS-23 (4), 1.0% n=27 Participants WS-23 block: 1.0%, no nicotine	WS-23 (5), 2.0% n=27 Participants WS-23 block: 2.0%, no nicotine	WS-23 (6), 4.0% n=27 Participants WS-23 block: 4.0%, no nicotine
Coolness: Score Change in Coolness of Each E-cigarette Condition (16 Conditions in Total)	2.70 Scores on a scale Standard Deviation 3.47	3.35 Scores on a scale Standard Deviation 5.78	5.43 Scores on a scale Standard Deviation 4.80	8.13 Scores on a scale Standard Deviation 6.15	11.61 Scores on a scale Standard Deviation 13.07	3.91 Scores on a scale Standard Deviation 7.37	4.14 Scores on a scale Standard Deviation 5.43	11.18 Scores on a scale Standard Deviation 11.23	12.23 Scores on a scale Standard Deviation 7.92	18.65 Scores on a scale Standard Deviation 12.54	4.52 Scores on a scale Standard Deviation 6.12	3.17 Scores on a scale Standard Deviation 4.21	8.22 Scores on a scale Standard Deviation 9.20	12.57 Scores on a scale Standard Deviation 11.21	17.69 Scores on a scale Standard Deviation 10.58	28.46 Scores on a scale Standard Deviation 15.37

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Suchitra Krishnan-Sarin and Danielle Davis

Yale University

Phone: 2039747607

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place