Alzheimer's Disease and Related Dementias (ADRD) Prevalence in American Samoa
NCT ID: NCT05924529
Last Updated: 2023-06-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
1098 participants
OBSERVATIONAL
2022-09-30
2025-09-30
Brief Summary
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Detailed Description
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Test ADRD knowledge, health literacy, research readiness and determine ADRD resilience and vulnerability factors, and cognitive status in a probability sample of 981 Samoans age 50+ using culturally adapted instruments in our probability sample.
Conduct Gold Standard evaluations in our probability sample using the Uniform Data Set (UDSv3.0) from the National Institute on Aging (NIA) Alzheimer's Disease Research Center program to determine a population-based prevalence of MCI and ADRD for harmonization, data sharing, and comparison to other groups, and,
Cross-validate Gold Standard dementia evaluations with genetic (i.e., ApoE) and plasma Amyloid-Tau-Neuronal Injury/Neurodegeneration (ATN) framework biomarkers in our probability sample and compare to information available for other racial/ethnic groups.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Samoans in American Samoa
Cognitive assessments will be administered to all participants to assess cognitive status. Gold standard evaluations will be administered to cross-validate the results of the cognitive assessments. Blood will be extracted from all participants to cross-validate results from the prior cognitive assessments and Gold Standard evaluations and conduct plasma and genetic analysis.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Community dwelling
* Speaks English or Samoan
* Willing to contribute a biomarker specimen
Exclusion Criteria
* Axis 1 Psychiatric diagnosis (e.g., Schizophrenia, Bipolar)
* Unstable medical condition (i.e., metastatic cancer) that could preclude completion of study visit
50 Years
ALL
No
Sponsors
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National Institutes of Health (NIH)
NIH
University of Miami
OTHER
University of California, San Francisco
OTHER
University of Hawaii
OTHER
American Samoa Community Cancer Coalition
OTHER
Responsible Party
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Principal Investigators
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Va'atausili Tofaeono, MS
Role: PRINCIPAL_INVESTIGATOR
American Samoa Community Cancer Coalition
Locations
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Malaloa GHC Reid Building
Pago Pago, , American Samoa
Sa'o Fetalai Building
Pago Pago, , American Samoa
Countries
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Central Contacts
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Facility Contacts
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Casuallen Atuatasi, PhD
Role: primary
Siumu Fa'ai'uaso, BS
Role: backup
Casuallen Atuatasi, PhD
Role: primary
Siumu Fa'ai'uaso, BS
Role: backup
References
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Tofaeono V, Ka'opua LSI, Sy A, Terada T, Taliloa-Vai Purcell R, Aoelua-Fanene S, Tong K, Tofaeono V, Unutoa-Mageo T, Scanlan L, Cassel K, Rosario A. Research Capacity Strengthening in American Samoa: Fa'avaeina le Fa'atelega o le Tomai Sa'ili'ili i Amerika Samoa. Br J Soc Work. 2020 Mar;50(2):525-547. doi: 10.1093/bjsw/bcz160. Epub 2019 Dec 31.
Williams S, Graupner J, Fernandes R, Gorawara-Bhat R. Healthcare providers attitudes and knowledge toward dementia in American Samoan culture. J Pain Sym Man 55:P680, 2017
Provided Documents
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Document Type: Informed Consent Form
Other Identifiers
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ASCCC0191792
Identifier Type: -
Identifier Source: org_study_id