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Cognitive Engagement and Aging Mind

NCT ID: NCT05924490

Last Updated: 2023-06-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

58 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2018-10-01

Brief Summary

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The purpose of this research is to examine whether and to what extent training of different types of cognitive engagement will improve performance on fluid cognitive abilities that typically decline with age. The research covered by this protocol will use behavioral data that yield response latencies and accuracies of the untrained tasks, and brain activations in fMRI tasks, to test specific hypotheses about neural plasticity and cognitive plasticity from these engagement techniques. Hence, human subjects will be employed in an experiment lasting for 20 hours spanning over 2 months where they will either receive real-time strategy-based videogame training or crystallized intelligence training. In addition, long-term retention data will be obtained after 6 month post-training to investigate any long-term benefits.

Detailed Description

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The purpose of this research is to examine whether and to what extent training of different types of cognitive engagement will improve performance on fluid cognitive abilities that typically decline with age (such as, speed of information processing, working memory capacity, episodic memory, and executive functions). The research covered by this protocol will use behavioral data that yield response latencies and accuracies of the untrained tasks, and brain activations in fMRI tasks, to test specific hypotheses about the extent of transfer, if any, and the underlying cognitive constructs that may be trained in the process. Hence, human subjects will be employed in an experiment lasting for 20 hours spanning over 2 months where they will either receive real-time strategy-based videogame training or crystallized intelligence training. In addition, long-term retention data will be obtained after 6 month post-training to investigate any long-term benefits.

Conditions

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Age-related Cognitive Decline

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Real-time strategy-based videogame training

Participants played a real-time strategy-based videogame in laboratory setting, Rise of Nations, for 2 hours a day, two days per week, for 5 weeks.

Group Type EXPERIMENTAL

Real-time strategy-based videogame training

Intervention Type BEHAVIORAL

Rise of Nation is a complex strategy-based video game, in which individualized-adaptive feedbacks are constantly given to players based on their performance.

Crystallized intelligence training

Participants completed a series of crossword puzzles each week, for 5-6 weeks. Training sessions were completed at the participants' home or area of preference. Participant received a periodic phone call (2 times per week) from research staff to update any notes or details regarding participants' study progress.

Group Type ACTIVE_COMPARATOR

Semantic Knowledge training

Intervention Type BEHAVIORAL

Packages of various cross-word puzzles include word search, word ladder, and word wheel.

Interventions

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Real-time strategy-based videogame training

Rise of Nation is a complex strategy-based video game, in which individualized-adaptive feedbacks are constantly given to players based on their performance.

Intervention Type BEHAVIORAL

Semantic Knowledge training

Packages of various cross-word puzzles include word search, word ladder, and word wheel.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Right-handed
* over 50 Years of Age
* native or fluent English speaker
* not Color-blind
* Magnetic Resonance Imaging eligible
* Mini Mental Status Examination Score \>24

Exclusion Criteria

* Left-handed or ambidextrous
* younger than 50
* cannot distinguish colors during color blindness test
* claustrophobia
* metal artifact in body
* over 300 lb
* pacemaker
* MMSE score lower than 24
* history of stroke
* history of substance or alcohol abuse
* currently taking anti-psychotic or anti-depression medication
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The University of Texas at Dallas

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Chandramallika Basak, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

The University of Texas at Dallas

Locations

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The Center for Vital Longevity (UT Dallas)

Dallas, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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IRB 12-57

Identifier Type: -

Identifier Source: org_study_id