Project 3: ACHIEVE- CHD

NCT ID: NCT05918380

Last Updated: 2025-07-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

500 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-08-15

Study Completion Date

2027-01-01

Brief Summary

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This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In Populations Through Early Prevention in the Great Lakes Region) Center (IRB 100221MP2A), the purpose of which is to reduce cardiometabolic health disparities and downstream Black-White lifespan inequality in two cities: Detroit, Michigan, and Cleveland, Ohio. The ACHIEVE GREATER Center will involve three separate but related projects that aim to mitigate health disparities in risk factor control for three chronic conditions, hypertension (HTN, Project 1), heart failure (HF, Project 2) and coronary heart disease (CHD, Project 3), which drive downstream lifespan inequality. All three projects will involve the use of Community Health Workers (CHWs) to deliver an evidence-based practice intervention program called PAL2. All three projects will also utilize the PAL2 Implementation Intervention (PAL2-II), which is a set of structured training and evaluation strategies designed to optimize CHW competence and adherence (i.e., fidelity) to the PAL2 intervention program. The present study is Project 3 of the ACHIEVE GREATER Center.

Detailed Description

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Conditions

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Coronary Heart Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Low CVD risk

PAL2

Group Type OTHER

PAL2

Intervention Type BEHAVIORAL

Low CVD risk participants (CAC \< 100) will be followed by their primary care provider accompanied by monthly contact with community health workers provided by ACHIEVE Greater who will screen participants for social determinants of health and implement the PAL2.

PAL2 is defined as a community health worked based intervention to mitigate psychosocial and health equity barriers to optimize health promotion coupled with high blood pressure and lifestyle disease state education.

High CVD risk

Center for Integrated and Novel Approaches in Vascular-Metabolic Disease (CINEMA)

Group Type OTHER

CINEMA

Intervention Type OTHER

High CVD risk participants (CAC ≥ 100) will be followed by specialists in the Center for Integrated and Novel Approaches in Vascular-Metabolic Disease (CINEMA) at UHCMC. While they too will be assessed, by the CHW for SDOH and a plan developed to address them, this plan will be addressed by the usual resources available in the CINEMA clinic.

Interventions

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PAL2

Low CVD risk participants (CAC \< 100) will be followed by their primary care provider accompanied by monthly contact with community health workers provided by ACHIEVE Greater who will screen participants for social determinants of health and implement the PAL2.

PAL2 is defined as a community health worked based intervention to mitigate psychosocial and health equity barriers to optimize health promotion coupled with high blood pressure and lifestyle disease state education.

Intervention Type BEHAVIORAL

CINEMA

High CVD risk participants (CAC ≥ 100) will be followed by specialists in the Center for Integrated and Novel Approaches in Vascular-Metabolic Disease (CINEMA) at UHCMC. While they too will be assessed, by the CHW for SDOH and a plan developed to address them, this plan will be addressed by the usual resources available in the CINEMA clinic.

Intervention Type OTHER

Other Intervention Names

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Pragmatic personalized, adaptable approach to lifestyle and life circumstance

Eligibility Criteria

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Inclusion Criteria

1. 40 to 75 years of age
2. Self-identified as Black or African American
3. Residence in the Cleveland Metro Area
4. Must have at least two of the following risk factors identified at a UH health fair screenings, with one risk factor being with SBP, A1c, or LDL:

1. BMI≥30 mg/dL
2. History of smoking
3. Elevated blood pressure defined as SBP\>140 or DBP\>80 mmHg
4. HbA1c≥5.7%
5. LDL≥130
5. Able to complete a coronary artery calcium score test (CAC)
6. Willing and able to consent
7. Willing to have a UH provider and UH care
8. Currently insured for standard of care procedures

Exclusion Criteria

1. Established documented cardiovascular disease (coronary artery disease, peripheral artery disease, myocardial infarction, stroke).
2. Systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg
3. Lung disease requiring supplemental oxygen therapy
4. Individuals receiving treatment for cancer related disease
5. Pregnant or nursing mothers
Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospitals Cleveland Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Sanjay Rajagopalan

Chief, Cardiovascular Medicine, Chief Academic and Scientific Officer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sanjay Rajagopalan, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospitals Cleveland Medical Center

Locations

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University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Sanjay Rajagopalan, MD

Role: CONTACT

216-844-5191

Heidi Osborne

Role: CONTACT

216-844-2833

Facility Contacts

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Sanjay Rajagopalan, MD

Role: primary

216-844-5191

Other Identifiers

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STUDY20220763

Identifier Type: -

Identifier Source: org_study_id

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