Impact of Tramadol Addiction On Dental Anesthesia Success
NCT ID: NCT05908305
Last Updated: 2023-06-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
300 participants
INTERVENTIONAL
2023-06-10
2023-10-15
Brief Summary
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Detailed Description
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The intraoperative pain being prevented by the administration of a local anesthesia must be followed by the management of the postoperative pain which can be often intense and thus requiring drugs administration. These drugs could be nonopioid or opioid analgesics which are also frequently used in general medicine as Tramadol.
Tramadol is 2-(dimethyl amino)-methyl)-1-(3'-methoxyphenyl) cyclohexanol hydrochloride. It is 4-phenyl-piperidine analogue of the opioid drug codeine. It is generally well tolerated with few and rare side effects. Moreover, comparative studies have mostly shown that Tramadol is more effective than NSAIDs for post operative pain control. However, its misuse is increasingly growing and has become obvious in Algeria.
Tramadol addiction has become very frequent, and its unjustified use is expanding. This might be attributed to the fragility of the health system and the replacement of the qualified pharmacists by non-qualified helpers or assistants.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
SCREENING
SINGLE
Study Groups
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Tramadol Addicted Patients
It represents the group of tramadol addicted patients seeking dental care that require dental anesthesia.
articaine@ (4% 1:100000 epinephrine) dental anesthesia
Administration, calculation and adjustment of dental local anesthesia doses.
Non addicted patients
The group of patients requiring dental care with local anesthesia and who are not addicted to tramadol.
articaine@ (4% 1:100000 epinephrine) dental anesthesia
Administration, calculation and adjustment of dental local anesthesia doses.
Interventions
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articaine@ (4% 1:100000 epinephrine) dental anesthesia
Administration, calculation and adjustment of dental local anesthesia doses.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* ≥18 years old \<65
* Without comorbid conditions (Hypertension, diabetes, Asthma etc..)
* Tramadol addicted (regular tramadol user)
* Only tramadol addicted, if any other drugs are regularly consumed, the patient is excluded.
Exclusion Criteria
* ˂ 18 years old
* With comorbid conditions (HTN, diabetes, epilepsy etc..)
* ≥ 65 years old men.
* Not addicted to tramadol or addicted to other drugs with it.
18 Years
65 Years
MALE
Yes
Sponsors
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University of Algiers
OTHER
Responsible Party
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Mohammed Amir Rais
Principal Investigator
Central Contacts
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References
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Carnaval TG, Sampaio RM, Lanfredi CB, Borsatti MA, Adde CA. Effects of opioids on local anesthesia in the rat: a codeine and tramadol study. Braz Oral Res. 2013 Nov-Dec;27(6):455-62. doi: 10.1590/S1806-83242013000600003.
Guven M, Mert T, Gunay I. Effects of tramadol on nerve action potentials in rat: comparisons with benzocaine and lidocaine. Int J Neurosci. 2005 Mar;115(3):339-49. doi: 10.1080/00207450590520948.
Premnath S, Alalshaikh G, Alfotawi R, Philip M. The Association Between Coffee Consumption and Local Anesthesia Failure: Social Beliefs and Scientific Evidence. Cureus. 2020 Apr 24;12(4):e7820. doi: 10.7759/cureus.7820.
Fung EY, Giannini PJ. Implications of drug dependence on dental patient management. Gen Dent. 2010 May-Jun;58(3):236-41; quiz 242-3.
Other Identifiers
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Tramadol Addict Impact On Dent
Identifier Type: -
Identifier Source: org_study_id
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