Rapid Autopsy Protocol for Patients With Small Cell Lung Cancer

NCT ID: NCT05889546

Last Updated: 2025-07-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-08-31

Study Completion Date

2031-12-31

Brief Summary

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This is pilot study to establish a rapid autopsy program in Small Cell Lung Cancer (SCLC) at the Indiana University Simon Comprehensive Cancer Center and outline the components necessary for tumor tissue collection.

Detailed Description

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The goal of this project to establish a rapid autopsy program in SCLC at the IUSCCC and outline the key components necessary for tumor tissue acquisition. This proposal is a collaboration between scientists, lung cancer physicians, pathologists, and the IUSCCC Translational Research Core. Tumor tissue collected will be used for protein and gene analysis and RNA, whole exome sequencing in addition to the establishment of SCLC. This research is part of a discovery project in which biological and molecular markers of SCLC will be identified.

Conditions

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Small Cell Lung Cancer

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Active SCLC Diagnosis

Biospecimen Collection

Intervention Type PROCEDURE

Lung, liver, skin, subcutaneous metastases, and blood specimens may be collected via rapid autopsy within 10 hours of expiration.

Interventions

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Biospecimen Collection

Lung, liver, skin, subcutaneous metastases, and blood specimens may be collected via rapid autopsy within 10 hours of expiration.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. ≥ 18 years old at the time of informed consent
2. Written informed consent and HIPAA authorization for release of personal health information.
3. Active SCLC diagnosis.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Indiana University

OTHER

Sponsor Role lead

Responsible Party

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Shadia Jalal

Associate Professor in the Department of Medicine at Indiana University

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Shadia I. Jalal, MD

Role: PRINCIPAL_INVESTIGATOR

Indiana University

Locations

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Indiana University Melvin and Bren Simon Comprehensive Cancer Center

Indianapolis, Indiana, United States

Site Status RECRUITING

Roudebush VA Medical Center

Indianapolis, Indiana, United States

Site Status RECRUITING

Sidney and Lois Eskenazi Hospital

Indianapolis, Indiana, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Gabby Kline, BA

Role: CONTACT

(317) 278-2514

Shadia I. Jalal, MD

Role: CONTACT

317-274-3589

Facility Contacts

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Gabby Kline, BA

Role: primary

317-278-2514

Shadia I. Jalal, MD

Role: backup

317-274-3589

Cynthia Johnson

Role: primary

317-278-7403

Shadia Jalal, MD

Role: backup

317-274-3589

Gaby Kline, BA

Role: primary

317-278-2514

Shadia I. Jalal, MD

Role: backup

317-274-3589

Other Identifiers

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CTO-IUSCCC-0783

Identifier Type: -

Identifier Source: org_study_id

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