The Effect of Mucogyne® Gel on Wound Healing

NCT ID: NCT05888194

Last Updated: 2024-03-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

118 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-12

Study Completion Date

2024-05-31

Brief Summary

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The aim of this post-market clinical follow up study is to confirm the efficacy and safety of topical application of Mucogyne® gel in the process of wound healing, when used in accordance with its approved labeling, in the context of postpartum perineal wounds.

Detailed Description

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Conditions

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Perineal Tear and Episiotomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

A multicenter, prospective, randomized controlled study
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Mucogyne group

In Mucogyne group, each eligible patient will receive a box of Mucogyne® gel. The patient will apply Mucogyne® gel, 48-hours after delivery, everyday, twice a day, massaging it into the intimate area, for a 10-day period.

Group Type EXPERIMENTAL

Mucogyne® gel

Intervention Type DEVICE

In Mucogyne group, each eligible patient will receive a box of Mucogyne® gel. The patient will apply Mucogyne® gel, 48-hours after delivery, everyday, twice a day, massaging it into the intimate area, for a 10-day period.

Control group

Standard of care e.i no treatment

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Mucogyne® gel

In Mucogyne group, each eligible patient will receive a box of Mucogyne® gel. The patient will apply Mucogyne® gel, 48-hours after delivery, everyday, twice a day, massaging it into the intimate area, for a 10-day period.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Adult women with singleton pregnancy
2. Have a perineal tear or mediolateral episiotomy
3. First (with cutaneous injury) and 2nd-degree perineal tear/episiotomy, whose length and depth are as the following:

* depth (from the fourchette into the greatest depth of the perineal body) ≤3cm,
* length of vaginal mucosa (from the fourchette to the apex of the vaginal tear) ≤4cm
* length of skin (from the fourchette along perineal skin towards the anus) ≤3cm
4. Is able to understand the study related information and to give a written informed consent,
5. Has signed the informed consent form before beginning any study procedure,
6. Has no condition that may interfere with the study assessments,
7. Is able to comply with protocol requirements and respect the conditions of the study,
8. Accept to come to the mentioned hospital 12(+/-2) days after childbirth
9. Affiliated to the Social Security system

Exclusion Criteria

1. Postpartum complications, or developed early bleeding after delivery
2. Third and fourth degree perineal tear.
3. Previous vaginal/perineal surgery within the year preceding the inclusion in the study
4. Had undergone extended episiotomy (incision size \> 3 - 4 cm)
5. Anal fissures.
6. Known hypersensitivity to any of the medical device ingredients
7. With local infectious lesions in the area to be repaired.
8. Who use drugs known to disturb wound healing (example : anticoagulants during pregnancy (based on self-reports))
9. Had a history of diseases known to disturb wound healing (e.g. systemic, heart, and renal diseases, coagulation disorders, immune deficiency, connective tissue disorders, diabetes, anemia (with hemoglobin level \< 9 g/dl) and hemophilia)
10. Immunosuppressive treatment.
11. Heavy cigarettes smoker (i.e., more than 15 cigarettes or equivalent/day, according to the mothers and their documented records),
12. Patients under legal protection or under guardianship and patients deprived of freedom
13. Has any other severe chronic or acute medical or psychiatric condition that in the judgment of the Investigator, could interfere with the study assessments
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Biocodex

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU Lille

Lille, , France

Site Status RECRUITING

CHU Montpellier

Montpellier, , France

Site Status RECRUITING

CHU Strasbourg

Strasbourg, , France

Site Status NOT_YET_RECRUITING

Countries

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France

Central Contacts

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Chloé GRZES

Role: CONTACT

+33 3 44 86 75 94

Facility Contacts

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Isis CACHO

Role: primary

+33 3 20 44 59 62

Clémentine COMBES

Role: primary

+33 4 67 33 65 12

Other Identifiers

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MUCG-233

Identifier Type: -

Identifier Source: org_study_id

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