Intranasal Versus Nebulized Midazolam in Behaviuor Modification of Preschool Children Undergoing Dental Treatment

NCT ID: NCT05883150

Last Updated: 2023-11-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-11-10

Study Completion Date

2023-08-30

Brief Summary

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The aim of the current study is to compare the effect of intranasal versus nebulized route of administration of midazolam as moderate sedative agents in preschoolers undergoing dental treatment.

Detailed Description

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Conditions

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Dental Sedation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants

Study Groups

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Nebulized Midazolam

Group Type EXPERIMENTAL

Nebulized Midazolam

Intervention Type DRUG

All the drug solutions will be freshly prepared on the day of sedation session. Depending on the dosage calculated from the weight of each child The sedative drug, the dosage will be diluted with an equal volume by adding distilled water.

The child will be seated in an upright position on the dental chair. Before placing the mask of the nebulizer, the child will be coached into proper breathing pattern

Intranasal Midazolam

Group Type ACTIVE_COMPARATOR

Intranasal Midazolam

Intervention Type DRUG

All the drug solutions will be freshly prepared on the day of sedation session. Depending on the dosage calculated from the weight of each child, For children who will receive midazolam using the atomization device attached to a three-ml syringe, the child sitting reclined in knee-to-knee position. Half of the dose will be sprayed in the right nostril and the other half will be sprayed in the left nostril to double the absorptive surface area by short and quick puffs

Interventions

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Nebulized Midazolam

All the drug solutions will be freshly prepared on the day of sedation session. Depending on the dosage calculated from the weight of each child The sedative drug, the dosage will be diluted with an equal volume by adding distilled water.

The child will be seated in an upright position on the dental chair. Before placing the mask of the nebulizer, the child will be coached into proper breathing pattern

Intervention Type DRUG

Intranasal Midazolam

All the drug solutions will be freshly prepared on the day of sedation session. Depending on the dosage calculated from the weight of each child, For children who will receive midazolam using the atomization device attached to a three-ml syringe, the child sitting reclined in knee-to-knee position. Half of the dose will be sprayed in the right nostril and the other half will be sprayed in the left nostril to double the absorptive surface area by short and quick puffs

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Frankl scale score 2.
* ASA I or II physical status.
* Dental intervention under local anesthesia not requiring more than 30 minutes.
* No previous dental experience.
* Parent/guardian's written consent.

Exclusion Criteria

* Dental treatment indicated under general anesthesia.
* Presence of facial or nasal deformities.
* History of neurological or cognitive alterations.
* Mouth breathers
Minimum Eligible Age

3 Years

Maximum Eligible Age

6 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nourhan M.Aly

OTHER

Sponsor Role lead

Responsible Party

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Nourhan M.Aly

Assistant Lecturer of Dental Public Health

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Amira A ElKhatib, PhD

Role: PRINCIPAL_INVESTIGATOR

Kafrelsheikh University, Kafrelsheikh, Egypt

Yousr Nader, MSc

Role: PRINCIPAL_INVESTIGATOR

Alexandria University

Locations

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Faculty of Oral and Dental Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt

Kafr ash Shaykh, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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210

Identifier Type: -

Identifier Source: org_study_id