Utidelone and Anlotinib in Advanced Recurrent Metastatic Esophageal Cancer

NCT ID: NCT05866510

Last Updated: 2023-05-19

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 47 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-05-15
• Study Completion Date: 2024-04-30

Brief Summary

The goal of this clinical trial is to evaluate the safety, tolerance and efficacy of Utidelone combined with Anlotinib in patients with Advanced or Recurrent Esophageal Carcinoma who failed Standard first line therapy.

Detailed Description

Patients with advanced or recurrent esophageal carcinoma who failed standard first-line therapy have a low survival prognosis. There are few treatment options available and the clinical need is great.

The aim of this study is to evaluate the efficacy and safety of Utidelone combined with Anlotinib in patients with Advanced or Recurrent Esophageal Carcinoma who fail first line therapy.

The trial is a single arm design. Patient in the treatment group will accept Utidelone at 30 mg/m2/d administered intravenously on days 1-5 and Anlotinib 8mg/d administered orally on days 1-14, 21 days as one cycle.

Before the use of utidelone, all patients will accept pretreatment: diphenhydramine 40 mg by intramuscular injection or oral administration, and dexamethasone10 mg and cimetidine 300 mg by intravenous injection 30 minutes prior to Utidelone iv drip at the first day of each cycle.

Tumor assessments will be performed at baseline and every 6 weeks (±7 days) after enrollment and will continue until disease progression according to RECIST v1.1 criteria. For patients with no disease progression, tumor evaluation will continue regardless of treatment discontinuation unless the patient begins new antitumor therapy or withdraws informed consent.

Conditions

Esophageal Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Utidelone and Anlotinib

The treatment group will be treated with Utidelone and Anlotinib until the presence of progressive disease or unacceptable toxicity.

Group Type: EXPERIMENTAL

Utidelone and anlotinib

Intervention Type: DRUG

Pretreatment: diphenhydramine 40 mg by intramuscular injection or oral administration, and dexamethasone10 mg and cimetidine 300 mg by intravenous injection 30 minutes prior to Utidelone iv drip at the first day of each cycle.

Utidelone will be given at 30 mg/m2/d administered intravenously on days 1-5 and Anlotinib 8mg/d took orally on days 1-14 every 21 days.

Interventions

Utidelone and anlotinib

Pretreatment: diphenhydramine 40 mg by intramuscular injection or oral administration, and dexamethasone10 mg and cimetidine 300 mg by intravenous injection 30 minutes prior to Utidelone iv drip at the first day of each cycle.

Utidelone will be given at 30 mg/m2/d administered intravenously on days 1-5 and Anlotinib 8mg/d took orally on days 1-14 every 21 days.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Histological and/or cytology confirmed advanced or unresectable recurrent esophageal carcinoma

2. All patients had failed first-line chemotherapy (disease progression or unacceptable toxicity occurs).

Patients may also be included if they receive standard neoadjuvant/adjuvant chemotherapy and relapse within 6 months of completion.

3. All patients were not accepted any treatment(chemotherapy, radiotherapy, surgery, etc.) within 4 weeks before enrollment.

4. The subject has at least one evaluable lesion (measurable or non-measurable) by the RECIST 1.1.

5. Male or female, ≥ 18 years of age, ≤ 75 years of age.

6. ECOG performance status 0-1.

7. Patients with a life expectancy of more than 3 months.

8. Baseline routine blood tests within 1 week prior to enrollment is normal. No rhG-CSF use and no blood transfusion/EPO etc. within 14 days prior to enrollment.

• Neutrophil count (ANC) ≥ 1.5 × 109/L.
• Hemoglobin ≥9.0 g/dL.
• platelet count (PLT) ≥ 80 × 109/L

9. Blood biochemistry test result is normal within 1 week prior to enrollment (based on normal values at each site's laboratory).

• Total bilirubin (TBIL) ≤ 1.5× the upper limit of normal value (ULN)
• Serum Glutamic Pyruvic Transaminase/Alanine Amino transferase (SGPT /ALT) ≤ 3× ULN (in the case of liver metastases ≤ 5 × ULN)
• Serum Glutamic-oxaloacetic Transaminase/Aspartate Aminotransferase (SGOT /AST) ≤ 3× ULN (in the case of liver metastases ≤ 5 × ULN)
• Creatinine clearance (Ccr) ≥50 ml/min.

10. Fertile males and females of childbearing potential must agree to use effective contraception during the study and within 90 days after the last dose. The blood or urine pregnancy test for female patients of childbearing age prior to enrollment must be negative.

11. Patients must sign the informed consent form and commit to complying with the requirements of this study.

Exclusion Criteria

1. Patients who have received antitumor therapy, including chemotherapy, radiotherapy, biologic therapy, targeted therapy, immunotherapy, or antitumor herbal therapy, within 4 weeks. With the exception of the following:

• Nitrosoureas or mitomycin C within 6 weeks prior to the first use of the study drug;
• Oral fluorouracil and small molecule targeted drugs for 2 weeks prior to the first use of the study drug or within the drug's 5 half-life (whichever is longer);
• Chinese medicines with antitumor indications within 2 weeks before the first use of the study drug.

2. Major organ surgery (excluding puncture biopsy) within 4 weeks prior to the first dose of study drug had major organ surgery (excluding puncture biopsy) or significant trauma within 4 weeks prior to the first dose of study drug, or required elective surgery during the trial.

3. Patients with symptomatic peripheral neuropathy with CTCAE 5.0 grade ≥2

4. Previous grade 3 or higher neurological related adverse reactions with anti-microtubule drugs.

5. Severe allergy to castor oil, or serious adverse effects from previous use of anti-microtubule drugs Those with severe allergy to castor oil or those who have experienced serious adverse reactions to previous anti-microtubule drugs.

6. Patients who are pregnant (positive result from the pregnancy test) or lactating.

7. Patients whose prior adverse reactions to anti-tumor therapy have not recovered to CTCAE 5.0 grade ≤1 (except for toxicity such as alopecia which poses no safety risk in the judgment of the investigator).

8. Patients with symptomatic CNS metastases or meningeal metastases, or uncontrollable metastases.

9. Patients with an active infection that currently requires systemic anti-infective therapy, including but not limited to: HIV, active hepatitis B/C infection.

10. Patients with history of severe cardiovascular disease

11. Patients with mental disorders or poor compliance.

12. Subjects who, in the opinion of the investigator, have a history of other serious systemic diseases, or other reasons that make participation in this trial inadvisable.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Beijing Biostar Pharmaceuticals Co., Ltd.

INDUSTRY

Sponsor Role: collaborator

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

INDUSTRY

Sponsor Role: collaborator

Peking University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

The First Affiliated Hospital of Xinxiang Medical University

Weihui, Henan, China

Site Status: NOT_YET_RECRUITING

Suining Central Hospital

Suining, Sichuan, China

Site Status: NOT_YET_RECRUITING

Beijing Cancer Hospital, Beijing, China

Beijing, , China

Site Status: RECRUITING

Countries

China

Central Contacts

Lin Shen, MD

Role: CONTACT

shenlin@bjmu.edu.cn

008688196561

Yanshuo Cao, MD

Role: CONTACT

yanshuo.cao@bjmu.edu.cn

008688196561

Facility Contacts

Yinghua Ji, MD

Role: primary

54234317@qq.com

0373-4402293

Na Li, MD

Role: primary

lny.yl@163.com

19911866118

Lin Shen, MD

Role: primary

shenlin@bjmu.edu.cn

008688196561

Yanshuo Cao, MD

Role: backup

yanshuo.cao@bjmu.edu.cn

008688196561

Other Identifiers

2022YJZ92

Identifier Type: -

Identifier Source: org_study_id