Phthalate and Bisphenol Exposure During Minipuberty

NCT ID: NCT05864209

Last Updated: 2025-06-10

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-05-16

Study Completion Date

2024-01-11

Brief Summary

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Phthalates and bisphenols have been detected in a range of infant care products. This pilot study will test whether intervening on these sources of exposure during the critical period of minipuberty affects infants' body burden of phthalates and bisphenols. Investigators will recruit 10 participants from the ongoing NYU Children's Health and Development Study (CHES) cohort study who are \>=37 weeks gestation, carrying a male fetus, and intending to breastfeed. Investigators will randomly assign them to use either conventional baby products or phthalate- and bisphenol-free baby products for the first three months of their children's lives. Toward the end of the intervention, investigators will collect maternal breast milk and infant urine, and assay samples for phthalate metabolite and bisphenol concentrations.

Detailed Description

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Conditions

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Phthalate Exposure Bisphenol Exposure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Intervention Group

Half of the participants will be randomly assigned to the intervention group and will receive a three-month supply of phthalate- and bisphenol-free baby products (e.g., wipes, diaper cream) and a subscription to a cloth diaper service. Participants will be contacted after 2 and 6 weeks over the phone and administered a brief adherence survey.

Group Type EXPERIMENTAL

Phthalate- and Bisphenol-free Baby Products

Intervention Type OTHER

3-month supply. Products include wipes and diaper cream.

Cloth Diapers

Intervention Type OTHER

Subscription to cloth diaper service.

Control Group

Half of the participants will be randomly assigned to the control group and provided with a three-month supply of conventional disposable diapers (e.g., Huggies or Pampers) and baby products (e.g., wipes, diaper cream). Participants will be contacted after 2 and 6 weeks over the phone and administered a brief adherence survey.

Group Type ACTIVE_COMPARATOR

Conventional Disposable Diapers

Intervention Type OTHER

3-month supply.

Conventional Baby Products

Intervention Type OTHER

Products include wipes and diaper cream.

Interventions

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Phthalate- and Bisphenol-free Baby Products

3-month supply. Products include wipes and diaper cream.

Intervention Type OTHER

Cloth Diapers

Subscription to cloth diaper service.

Intervention Type OTHER

Conventional Disposable Diapers

3-month supply.

Intervention Type OTHER

Conventional Baby Products

Products include wipes and diaper cream.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Enrolled in NYU CHES study at the NYULH-Brooklyn campus
2. 18 years of age or older
3. At least 37 weeks gestation
4. Carrying a male singleton fetus
5. Intending to breastfeed
6. English or Spanish speaking
7. Intending for pediatric care for infant to occur at the Sunset Park Family Health Center at NYU Langone

Exclusion Criteria

1. Not enrolled in NYU CHES study from the NYULH-Brooklyn campus
2. Under 37 weeks gestation
3. Carrying a female fetus
4. Carrying multiples
5. Not intending to breastfeed
6. Not comfortable communicating in English or Spanish
7. Not intending for pediatric care for infant to occur at NYULH Sunset Park Family Health Center
8. Under 18 years of age
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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NYU Langone Health

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Linda G Kahn, PhD, MPH

Role: PRINCIPAL_INVESTIGATOR

NYU Langone Health

Locations

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Sunset Park Family Health Center at NYU Langone - Second Avenue

Brooklyn, New York, United States

Site Status

Tisch Hospital

New York, New York, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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23-00367

Identifier Type: -

Identifier Source: org_study_id

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