Targeted Motor Learning to Improve Gait for Individuals With Parkinson Disease
NCT ID: NCT05864157
Last Updated: 2025-11-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
45 participants
INTERVENTIONAL
2023-08-16
2026-05-03
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Control
Participants will perform walking practice on a treadmill and overground without the use of a metronome.
Gait training without rhythmic auditory cues
Gait training on treadmill and overground without any rhythmic auditory cues
Targeted Rhythmic Auditory Cueing (TRAC)
Participants will perform walking practice on a treadmill (with a metronome set to 85% of typical cadence) and overground (with a metronome set to 115% of typical cadence).
TRAC
Metronome set to 85% on treadmill and 115% when walking overground
Distorted Targeted Rhythmic Auditory Cueing (dTRAC)
Participants will perform walking practice on a treadmill (with a metronome set around 85% of typical cadence) and overground (with a metronome set around 115% of typical cadence).
dTRAC
Metronome set around 85% on treadmill and around 115% when walking overground
Interventions
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Gait training without rhythmic auditory cues
Gait training on treadmill and overground without any rhythmic auditory cues
TRAC
Metronome set to 85% on treadmill and 115% when walking overground
dTRAC
Metronome set around 85% on treadmill and around 115% when walking overground
Eligibility Criteria
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Inclusion Criteria
* self-report the ability to walk uninterrupted for 10 minutes both overground and on a treadmill without therapist assistance
* comfortable gait speed \> 0.4 m/s and \< 1.2 m/s
* normal (or corrected to normal \[i.e., hearing aid\]) hearing
* deficits in gait continuity (e.g., shuffling, shortened strides, freezing, festination, bradykinesia, etc) based on observational gait analysis
* Movement Disorders Society - Unified Parkinson Disease Rating Scale (MDS-UPDRS-III) item 10 ≥1 and \<3
* be on stable doses of orally-administered levodopa
* age 50-80 years old
Exclusion Criteria
* cognitive deficits (Montreal Cognitive Assessment \[MoCA\] \< 26)
* concurrent Physical Therapy
* have undergone deep brain stimulation surgery
* cannot walk without therapist assistance
* uncontrolled cardiorespiratory/metabolic disease, or other neurological disorders or orthopedic injury that may affect gait.
50 Years
80 Years
ALL
No
Sponsors
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Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
University of North Carolina, Chapel Hill
OTHER
Responsible Party
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Principal Investigators
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Mike Lewek, PT, PhD
Role: PRINCIPAL_INVESTIGATOR
Associate Professor
Locations
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University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Countries
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Central Contacts
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Facility Contacts
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Michael Lewek, PT, PhD
Role: primary
Other Identifiers
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23-0021
Identifier Type: -
Identifier Source: org_study_id