Real World Evidence on the Use of Medical Cannabis in Pediatrics

NCT ID: NCT05863910

Last Updated: 2023-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-11-20

Study Completion Date

2027-12-31

Brief Summary

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CAN-RWE is an observational study that is following 500 children who have authorizations for medical cannabis for two years from across Canada.

Detailed Description

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Pediatric patients (3 to 17 years) using medical cannabis (MC) for pain, sleep, mood, behaviour, seizures, treatment of cancer, or to manage symptoms related to cancer or cancer-treatment are eligible to join this 24-month study if they have a valid MC authorization.

Following screening, eligible participants will be contacted by the study coordinator. Following informed consent, study participants will record complete outcome measures on pain, sleep, mood (anxiety, depression and positive affect), behaviour, as well as report their cannabis use and indication-specific outcomes as applicable at 3, 6, 12, and 18 weeks, as well as 6, 12, 18 and 24-months.

Conditions

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Cancer Epilepsy Neurodevelopmental Disorders

Keywords

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cannabinoids cannabis pediatrics

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Epilepsy Cohort

For children with epilepsy, the following tools will be added for data collection at each time point:

* Side effects: Pediatric Epilepsy Side Effects Questionnaire \[PESQ\]
* Seizure frequency/severity: Seizure Diary Data Questionnaire

Medical Cannabis

Intervention Type DRUG

Any cannabis product that is available to participants through the Medical Cannabis Access Program is eligible to be included in this study.

Cancer Cohort

For children with cancer, the following tools will be added for data collection at each time point:

* Cancer symptom burden: Symptom Screening in Pediatrics Tool \[SSPedi\]
* Cachexia: Pediatric Functional Assessment of Anorexia/ Cachexia Treatment \[peds-FAACT\]

Medical Cannabis

Intervention Type DRUG

Any cannabis product that is available to participants through the Medical Cannabis Access Program is eligible to be included in this study.

General Pediatrics Cohort

There are no specific outcome scales added for this cohort.

Medical Cannabis

Intervention Type DRUG

Any cannabis product that is available to participants through the Medical Cannabis Access Program is eligible to be included in this study.

Interventions

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Medical Cannabis

Any cannabis product that is available to participants through the Medical Cannabis Access Program is eligible to be included in this study.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 3 to 17 years
* have a medical document provided by a prescribing health care practitioner (i.e. physician, nurse practitioner, etc.) for the use of medical cannabis
* medical cannabis is authorized for pain, sleep, mood, behaviour, seizures, cancer or cancer-treatment related symptom management
* ability to respond to electronic questionnaires in English

Exclusion Criteria

* individuals using cannabis for medical purposes without a medical cannabis authorization from a health care provider
* those only using cannabis recreationally
Minimum Eligible Age

3 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Canadian Collaborative for Childhood Cannabinoid Therapeutics

UNKNOWN

Sponsor Role collaborator

Canadian Cancer Society (CCS)

OTHER

Sponsor Role collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

Sponsor Role collaborator

University of Manitoba

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sapna Oberoi, MD

Role: PRINCIPAL_INVESTIGATOR

University of Manitoba

Taylor Lougheed, MD

Role: PRINCIPAL_INVESTIGATOR

Northern Ontario School of Medicine

Evan Lewis, MD

Role: PRINCIPAL_INVESTIGATOR

Neurology Centre of Toronto

Locations

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U Manitoba

Winnipeg, Manitoba, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Lauren E Kelly, PhD

Role: CONTACT

Phone: 2042723149

Email: [email protected]

Facility Contacts

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Lauren Kelly, PhD

Role: primary

Related Links

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http://www.medcannkids.ca

For more information on our research team visit our website.

Other Identifiers

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CAN-RWE

Identifier Type: -

Identifier Source: org_study_id