EFFECTIVENESS OF SINGLE DOSE ORAL DEXAMETHASONE VERSUS MULTIDOSE PREDNISOLONE FOR TREATMENT OF ACUTE EXACERBATIONS OF ASTHMA AMONG CHILDREN ATTENDING THE EMERGENCY DEPARTMENT OF CHILDREN HOSPITAL, ISLAMABAD

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

192 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-26

Study Completion Date

2023-12-26

Brief Summary

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In this Study i'll compare the effectiveness of two drugs used in acute exacerbation of asthma by their sideffects, complaince and improvement in the PRAM score. The better one would be adapted in our clinical practice.

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Detailed Description

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Conditions

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Asthma in Children

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Oral Single dose dexamethsone in acute exacerbation of asthma

Group Type ACTIVE_COMPARATOR

Dexamethasone

Intervention Type DRUG

Oral Dexamethasone a longer and potent corticosteroid with lesser sideffects and good compliance

Oral Multidose Prednisolone in acute exacerbation of asthma

Group Type ACTIVE_COMPARATOR

Prednisolone

Intervention Type DRUG

Oral Multidose Prednisolone

Interventions

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Dexamethasone

Oral Dexamethasone a longer and potent corticosteroid with lesser sideffects and good compliance

Intervention Type DRUG

Prednisolone

Oral Multidose Prednisolone

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* i.Ages 2 to 12years ii. Previous history of asthma as diagnosed by a physician. iii. Presentation with acute exacerbation of asthma with symptoms of cough, wheeze, dyspnoea and oxygen saturation of less than 95% and with PRAM score of more than or equal to 6

Exclusion Criteria

* i.Critical or life-threatening asthma i.e. patient with silent chest, cyanosis, drowsy, unable to verbalize, marked tachycardia and respiratory distress. ii.Known TB exposure iii.Fever more than 39. 5°C iv.Use of corticosteroids in previous 4 weeks v.Significant co-morbid disease: lung, cardiac, immune, liver, endocrine, neurological or psychiatric

Minimum Eligible Age

2 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No