Latent Tuberculosis in Healthcare Workers - the Reality of a Portuguese Tertiary Hospital
NCT ID: NCT05847491
Last Updated: 2023-05-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2022-09-01
2023-12-31
Brief Summary
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Detailed Description
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In Portugal the real prevalence of LTBI in low-risk HCWs has not been evaluated since they are not included in the periodic screening programs. It is important to diagnose TB infections in HCWs to prevent nosocomial transmission, particularly among immunocompromised patients.
The risk for transmission varies by setting, occupational group, local prevalence of TB, patient population, and effectiveness of TB infection control measures.
Prevention of active TB disease by treatment of LTBI is a critical component for public health.
Tuberculin skin test (TST) is used worldwide to diagnose LTBI, whereas interferon-γ release assay (IGRA) are used in some countries according to their national TB programs. IGRA offers a potential method of serial testing to diagnose LTBI in HCWs, and it has better specificity than that of TST in one-time screening.
Study participants should be identified and contacted by occupational health service. In association, study information should be disseminated through posters and institutional email.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Healthcare workers
Clinical evaluation, chest x-ray and Interferon-γ release assay (IGRA). Immunocompromised patients will be submitted to a tuberculin skin test.
The patients will be evaluated in two or more separate appointments. In the first appointment, patients will be submitted to clinical evaluation and exam request. In the second appointment the results will be evaluated.
IGRA/Tuberculin skin test
All patients will receive:
* Clinical evaluation;
* Chest x-ray.
* IGRA (or tuberculin skin test if immunocompromised)
* Therapeutic proposal if eligible
Interventions
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IGRA/Tuberculin skin test
All patients will receive:
* Clinical evaluation;
* Chest x-ray.
* IGRA (or tuberculin skin test if immunocompromised)
* Therapeutic proposal if eligible
Eligibility Criteria
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Inclusion Criteria
* Acceptance to participate and signed informed consent form
Exclusion Criteria
* Active Tuberculosis
* Refusal to sign the informed consent form
18 Years
ALL
Yes
Sponsors
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Centro Hospitalar do Oeste
OTHER
Responsible Party
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Principal Investigators
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Carina Rolo Silvestre, MD, MSc
Role: PRINCIPAL_INVESTIGATOR
Centro Hospitalar do Oeste
Locations
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Centro Hospitalar do Oeste - Torres Vedras
Torres Vedras, Lisbon District, Portugal
Countries
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Central Contacts
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Facility Contacts
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References
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Adams S, Ehrlich R, Baatjies R, van Zyl-Smit RN, Said-Hartley Q, Dawson R, Dheda K. Incidence of occupational latent tuberculosis infection in South African healthcare workers. Eur Respir J. 2015 May;45(5):1364-73. doi: 10.1183/09031936.00138414. Epub 2015 Feb 19.
Almufty HB, Abdulrahman IS, Merza MA. Latent Tuberculosis Infection among Healthcare Workers in Duhok Province: From Screening to Prophylactic Treatment. Trop Med Infect Dis. 2019 May 23;4(2):85. doi: 10.3390/tropicalmed4020085.
Apriani L, McAllister S, Sharples K, Alisjahbana B, Ruslami R, Hill PC, Menzies D. Latent tuberculosis infection in healthcare workers in low- and middle-income countries: an updated systematic review. Eur Respir J. 2019 Apr 18;53(4):1801789. doi: 10.1183/13993003.01789-2018. Print 2019 Apr.
Chen B, Gu H, Wang X, Wang F, Peng Y, Ge E, Upshur R, Dai R, Wei X, Jiang J. Prevalence and determinants of latent tuberculosis infection among frontline tuberculosis healthcare workers in southeastern China: A multilevel analysis by individuals and health facilities. Int J Infect Dis. 2019 Feb;79:26-33. doi: 10.1016/j.ijid.2018.11.010. Epub 2018 Nov 22.
Costa JC, Silva R, Ferreira J, Nienhaus A. Active tuberculosis among health care workers in Portugal. J Bras Pneumol. 2011 Sep-Oct;37(5):636-45. doi: 10.1590/s1806-37132011000500011. English, Portuguese.
Park Y, Kim SY, Kim JW, Park MS, Kim YS, Chang J, Kang YA. Serial testing of healthcare workers for latent tuberculosis infection and long-term follow up for development of active tuberculosis. PLoS One. 2018 Sep 20;13(9):e0204035. doi: 10.1371/journal.pone.0204035. eCollection 2018.
Other Identifiers
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LTBCHO23
Identifier Type: -
Identifier Source: org_study_id
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