Short-term Sintilimab in Combination With Taxane and Carboplatin for Neoadjuvant Therapy in Triple-negative Breast Cancer

NCT ID: NCT05843292

Last Updated: 2023-06-06

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE4
• Total Enrollment: 48 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-07-01
• Study Completion Date: 2034-12-31

Brief Summary

The goal of this clinical trial is to learn about the efficacy and safety of short-term sintilimab in combination with taxane and carboplatin for neoadjuvant therapy in female early-stage triple-negative breast caner patients aging from 18 to 70 years with unilateral and invasive primary lesions above 1cm. The main questions it aims to answer are:

1. Does short-term sintilimab in combination with taxane and carboplatin lead to acceptible pathological complete response (pCR) rates, objective response rates (ORR), event-free survival (EFS) and overall survival (OS)?

2. Does short-term sintilimab in combination with taxane and carboplatin lead to less adverse events than regular-term ICIs reported in literature?

Participants will be given 2 cycles of sintilimab, in combination with 4 cycles of taxane and carboplatin before surgery. An optional core-needle biopsy is performed after completing 2 cycles of sintilimab. All participants will be given regular follow-up post surgery according to ASCO guidelines.

Conditions

Triple-negative Breast Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Short-term Sintilimab in Combination With Taxane and Carboplatin

Prior to surgery: 2 cycles of sintilimab, in combination with 4 cycles of taxane and carboplatin

Group Type: EXPERIMENTAL

Taxane and Carboplatin

Intervention Type: DRUG

Nab-paclitaxel 100mg/m2+ Carboplatin AUC2 by intravenous (IV) infusion on day1, day8 and day15, every 4 weeks, for 4 cycles.

or Docetaxel 75mg/m2+ Carboplatin AUC5 by intravenous (IV) infusion on day1, every 3 weeks, for 4 cycles.

or Paclitaxel 80mg/m2+ Carboplatin AUC2 by intravenous (IV) infusion on day1, day8 and day15, every 4 weeks, for 4 cycles.

Short-term Sintilimab

Intervention Type: DRUG

Sintilimab 200mg by intravenous (IV) infusion on day1, every 3 weeks, for 2 cycles.

Surgery

Intervention Type: PROCEDURE

All participants who are eligible for surgery will undergo surgery and have their pathologic response evaluated.

Interventions

Taxane and Carboplatin

Nab-paclitaxel 100mg/m2+ Carboplatin AUC2 by intravenous (IV) infusion on day1, day8 and day15, every 4 weeks, for 4 cycles.

or Docetaxel 75mg/m2+ Carboplatin AUC5 by intravenous (IV) infusion on day1, every 3 weeks, for 4 cycles.

or Paclitaxel 80mg/m2+ Carboplatin AUC2 by intravenous (IV) infusion on day1, day8 and day15, every 4 weeks, for 4 cycles.

Intervention Type: DRUG

Short-term Sintilimab

Sintilimab 200mg by intravenous (IV) infusion on day1, every 3 weeks, for 2 cycles.

Intervention Type: DRUG

Surgery

All participants who are eligible for surgery will undergo surgery and have their pathologic response evaluated.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Age: 18-70 years, female;

2. Unilateral, invasive, primary breast cancer, T≥1cm, cN0-3, M0;

3. Immunohistochemistry(IHC): ER, PR<10%; HER-2 IHC "0", OR IHC "+", OR IHC "++" AND fluorescence in situ hybridization (FISH) negative;

4. At least one measurable lesion according to RECIST V1.1;

5. Newly or recently-collected core needle biopsy specimen of the primary lesion available for PD-L1 status determination;

6. ECOG score 0 or 1 within 10 days prior to drug administration;

7. Currently not pregnant or breastfeeding, and meet at least one of the following conditions:

1. NOT women of childbearing potential (WOCBPs).

2. WOCBPs that strictly adopt contraceptive measures during treatment and within at least 6 months after last drug administration.

8. Organs well-functioned according to laboratory examination and imaging;

9. Having good compliance with treatment plans, being capable of understanding the research process, and having signed a written informed consent.

Exclusion Criteria

1. Bilateral invasive breast cancer or metastatic (Stage IV) breast cancer;

2. With severe cardiovascular conditions:

1. Myocardial infarction, acute coronary syndrome or PCI/CABG within 6 months;

2. Current NYHA II-IV congestive heart failure (CHF) or past history of NYHA III-IV CHF.

3. Immunodeficiency, or undergoing systemic steroid therapy or any form of immunosuppressive therapy within 7 days prior to drug administration;

4. Active autoimmune diseases requiring systemic treatment within the past 2 years;

5. Known history of active tuberculosis caused by Bacillus Tuberculosis;

6. History of non infectious pneumonia requiring steroid treatment, or active pneumonia of all types;

7. Severe systemic infections, or other serious illnesses;

8. History of other malignant tumors within the past 5 years, except cured cervical carcinoma in situ and non-melanoma skin cancer;

9. Known history of human immunodeficiency virus (HIV) infection;

10. Active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection;

11. Known allergy or intolerance to therapeutic drugs or their excipients;

12. History of receiving cytotoxic chemotherapy, endocrine therapy, biological therapy or radiation therapy for any reason;

13. History of receiving anti PD-1, anti PD-L1, or anti PD-L2 drugs; or targeted drugs that act on stimulating or co-inhibitory T cell receptors (CTLA-4, OX 40, CD137 etc.);

14. Enrolled in a study of an investigational drug/instrument and given intervention within 4 weeks prior to drug administration for regular drugs/instruments and within 12 months for anticancer or anti-proliferative drugs/instruments;

15. Live vaccine (including but not limited to the following: measles, mumps, rubella, chickenpox/shingles, yellow fever, rabies, BCG, typhoid vaccines, and nasal influenza vaccines such as FluMist®) inoculation within 30 days prior to drug administration;

16. History of mental illness or drug abuse that may affect compliance with trial requirements;

17. During pregnancy or breastfeeding, or WOCABs that refuse to adopt strict contraceptive measures;

18. Deemed to be not appropriate for participating in this study by researchers.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Innovent Biologics, Inc.

OTHER

Sponsor Role: collaborator

CSPC Ouyi Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role: collaborator

Shanghai Jiao Tong University School of Medicine

OTHER

Sponsor Role: lead

Responsible Party

Kunwei Shen

Professor, Director of Comprehensive Breast Health Center, Ruijin Hospital

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Jiayi Wu

Role: CONTACT

pinkscorpio@163.com

0086-021-64370045

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Other Identifiers

NeoSTEP

Identifier Type: -

Identifier Source: org_study_id