Does Muscle Mass At Intensive Care Unit Admission Determine Mortality: the Memo Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

4000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-01

Study Completion Date

2025-10-31

Brief Summary

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This retrospective monocentric study aims to investigate whether a low muscle mass at ICU admission and its loss over the ICU stay predicts mortality, and in what proportion we can counteract it by nutritional support.

Detailed Description

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The study hypothesis is that a low muscle mass at ICU admission, measured at the level of L3 on CT scans performed for clinical routine, and its change over the ICU stay predict the prognosis of the patient, especially the 30-day mortality, that it may at least be partly counteracted by nutritional support and that it is related with higher ICU and hospital costs.

The objectives of this retrospective study are to determine:

1. the link between baseline body composition at ICU admission and outcomes, such as 30-day, ICU and hospital mortality and LOS, and infections. If this is confirmed, we aim to evaluate the added values of body composition to ICU severity scores to predict 30-day mortality
2. the link between baseline body composition vs. other locations to predict outcomes
3. the impact of body composition changes on the afore-mentioned outcomes. If this is confirmed, we aim to evaluate the added value of changes in body composition to changes in ICU severity scores to predict 30-day mortality
4. the impact of nutritional support on body composition changes

Conditions

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Lean Body Mass

Keywords

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Muscle mass Skeletal muscle area Third lumbar Tomography Intensive care unit

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Interventions

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exposure(s) of interest : intensive care unit

Low muscle mass is highly prevalent at hospital admission, and muscle mass generally decreases during hospital stay, especially in critically-ill patients. We would like to mesure muscle mas in critically ill patients and determine the association between outcomes.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Associations of baseline body composition with clinical outcomes:

Adults ≥ 18 yrs, hospitalized in the ICU of the HUG between January 1st 2010 and December 31st 2022 and Abdominal, or thoraco-abdominal CT scan measured 48 hours before to 96 hours after ICU admission in the HUG

* Associations of body composition changes with clinical outcomes, nutritional support or medico-economic paratemers:

Identical as for the associations of baseline body composition with clinical outcomes and At least one additional CT performed during the hospital stay

Exclusion Criteria

* Associations of baseline body composition with clinical outcomes:

CT scans of low quality or CT scans performed outside of the HUG or Presence of a documented refusal

* Associations of body composition changes with clinical outcomes, nutritional support or medico-economic paratemers:

Additionnally: oral nutrition, because we cannot assess the quantity and composition of oral intakes retrospectively

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Genton Graf Laurence

Prof.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Laurence Genton, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Geneva

Locations

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Laurence Genton

Geneva, Canton of Geneva, Switzerland

Site Status

Countries

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Switzerland

References

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Genton L, Bertoni Maluf VA, Herrmann FR, Prado CM, de Watteville A, Dupertuis YM, Collet TH, Platon A, Heidegger CP. Obesity is associated with lower 30-day mortality in critically ill patients: A retrospective study of over 5400 patients. Clin Nutr ESPEN. 2025 Oct;69:37-44. doi: 10.1016/j.clnesp.2025.06.046. Epub 2025 Jun 30.

Reference Type DERIVED

PMID: 40602605 (View on PubMed)

Other Identifiers

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2022-01773

Identifier Type: -

Identifier Source: org_study_id