Ultrasound Imaging of Fibrotic Tissue

NCT ID: NCT05818904

Last Updated: 2023-11-08

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 150 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-05-01
• Study Completion Date: 2024-12-31

Brief Summary

This project intends to collect the ultrasonic spectrum information of shoulder and knee joint fibrotic tissue, and use machine learning to study the mechanism of fibrosis tissue ultrasound imaging, and then build a model and finally establish the relationship between joint stiffness and fibrosis formation. In this study, the broadband ultrasound imaging method for joint fibrosis has the potential to create a method for ultrasonic localization, staining and evaluation of joint fibrosis, laying the foundation for the research of new conservative treatment methods and surgical positioning for fibrosis, and for reducing the occurrence of joint fibrosis rate, improve joint function of patients, and return to family and society earlier and better

Conditions

Arthrofibrosis of Knee; Arthrofibrosis of Shoulder

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Healthy

Healthy group is recruited. They would not receive any intervention. The ultrasound imaging data will be collected to serve as the comparison for no fibrosis joint.

No interventions assigned to this group

Arthrosis of knee

People with arthrosis of the knee joint will be treated using the traditional intervention, which includes physical therapy. The ultrasound imaging will be collected before the intervention and at 3-month. The imaging data will be used to build a imaging model using the machine learning method.

Physical Therapy

Intervention Type: OTHER

All arthrosis participants will be treated as the traditional methods using physical therapy.

arthrosis of shoulder

People with arthrosis of the shoulder joint will be treated using the traditional intervention, which includes physical therapy. The ultrasound imaging will be collected before the intervention and at 3-month. The imaging data will be used to build a imaging model using the machine learning method.

Physical Therapy

Intervention Type: OTHER

All arthrosis participants will be treated as the traditional methods using physical therapy.

Interventions

Physical Therapy

All arthrosis participants will be treated as the traditional methods using physical therapy.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. Unilateral shoulder or knee joint stiffness and normal on the opposite side

2. The course of the disease is longer than 3 months

3. Good cognitive function, able to understand the content of this experiment, willing to cooperate with follow-up

4. Over 18 years old, voluntarily participate in this study, and sign the informed consent

Exclusion Criteria

1. Wound non-healing, joint dislocation or unstable fracture fixation, pseudarthrosis, joint purulent infection and other contraindications for joint range of motion examination

2. There are skin lesions, wounds or allergies to the coupling agent on the joint surface and other conditions that cannot be used for ultrasound examination

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Peking University Third Hospital

OTHER

Sponsor Role: lead

Responsible Party

Zhou Mouwang

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Peking University Third Hospital

Beijing, , China

Site Status: RECRUITING

Countries

China

Central Contacts

Buwen Yao, PhD

Role: CONTACT

buwenyao@gmail.com

15600555851

Facility Contacts

Buwen Yao

Role: primary

Other Identifiers

M2022793

Identifier Type: -

Identifier Source: org_study_id