Immunohistochemical Evaluation of DNA Methylation and Histone Modification in H. Pylori Associated Gastric Carcinoma
NCT ID: NCT05811546
Last Updated: 2023-04-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
68 participants
OBSERVATIONAL
2022-05-01
2024-12-31
Brief Summary
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* How does H. pylori infection cause gastric cancer?
* Can DNA methylation and other epigenetic changes predict and affect the development of gastric cancer? Formalin-fixed-paraffin-embedded tissue specimens will be obtained and reviewed for comparison between epigenetic changes in H. pylori gastritis and gastric adenocarcinoma.
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Detailed Description
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Conditions
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Study Design
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OTHER
CROSS_SECTIONAL
Study Groups
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H. pylori Gastritis specimens
Immunohistochemical staining for DNMT1 and EZH2
Immunohistochemical staining for DNMT1 and EZH2 using rabbit monoclonal/polycolonal antibodies with immunoperoxidase staining will be used as a visualization method. Antibodies dilutions, antigen retrieval methods, and incubation time will all be conducted according to the manufacturer's instructions.
Non-H. pylori Gastritis specimens
No interventions assigned to this group
Gastric carcinoma specimens
No interventions assigned to this group
Interventions
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Immunohistochemical staining for DNMT1 and EZH2
Immunohistochemical staining for DNMT1 and EZH2 using rabbit monoclonal/polycolonal antibodies with immunoperoxidase staining will be used as a visualization method. Antibodies dilutions, antigen retrieval methods, and incubation time will all be conducted according to the manufacturer's instructions.
Eligibility Criteria
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Inclusion Criteria
* Available full clinical data: (age, sex, complaint, findings in clinical examination).
* Full data of previous endoscopy and radiology.
Exclusion Criteria
* Any case of gastric cancer, H. Pylori associated gastritis, non-H. Pylori gastritis, benign gastric lesions with missing clinical, endoscopic, radiologic or follow-up data.
* Cases with no available H\&E stained slides or formalin fixed paraffin embedded block.
30 Years
100 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Aliyah Soliman Ali
Pathology resident
Locations
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Assiut University
Asyut, , Egypt
Countries
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Facility Contacts
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Other Identifiers
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Epigenetics Gastric Carcinoma
Identifier Type: -
Identifier Source: org_study_id
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