A Multiple Ascending Dose Study in Healthy Volunteers and Patients With Alzheimer's Disease
NCT ID: NCT05804383
Last Updated: 2025-11-06
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Clinical Phase
PHASE1
Total Enrollment
51 participants
Study Classification
INTERVENTIONAL
Study Start Date
2023-03-28
Study Completion Date
2025-10-15
Brief Summary
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A Phase 1b Multiple Ascending Dose Study of the Safety and Tolerability of BMS-984923 in Healthy Older Adults and Patients with Alzheimer's Disease
Detailed Description
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This double-blind placebo-controlled study will be completed in 2 stages. The first stage will evaluate 10-days of BID dosing in four ascending dose cohorts in healthy older adults and Stage 2 will examine BMS-984923 dosed BID for 28 days at two dose levels in comparison to Placebo in participants with early AD.
This research study will assess the safety and tolerability of multiple doses of BMS-984923 for the treatment of early Alzheimer's Disease (AD) and investigate the use of synaptic density, measured with positron emission tomography (PET), as an early marker of therapeutic response to treatments that target synapse restoration.
This research study will assess the safety and tolerability of multiple doses of BMS-984923 for the treatment of early Alzheimer's Disease (AD) and investigate the use of synaptic density, measured with positron emission tomography (PET), as an early marker of therapeutic response to treatments that target synapse restoration.
Conditions
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Alzheimer's Disease
Keywords
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Alzheimer's Disease
Synapses
Cognition
Neuroprotection
Neurons
mGluR5
Study Design
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Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
BASIC_SCIENCE
Blinding Strategy
TRIPLE
Participants
Caregivers
Investigators
Placebo capsules
Study Groups
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50 mg active
BMS-984923 50 mg in healthy participants
Group Type
EXPERIMENTAL
BMS-984923
Intervention Type
DRUG
Capsules
50 mg Placebo
Placebo 50 mg in healthy participants
Group Type
PLACEBO_COMPARATOR
Placebo
Intervention Type
DRUG
Capsules
100 mg Active
BMS-984923 100 mg in healthy participants
Group Type
EXPERIMENTAL
BMS-984923
Intervention Type
DRUG
Capsules
100 mg Placebo
Placebo 100 mg in healthy participants
Group Type
PLACEBO_COMPARATOR
Placebo
Intervention Type
DRUG
Capsules
100 mg Active 20d
BMS-984923 100 mg in healthy participants 20 days
Group Type
EXPERIMENTAL
BMS-984923
Intervention Type
DRUG
Capsules
100 mg Placebo 20d
Placebo 100 mg in healthy participants 20 days
Group Type
PLACEBO_COMPARATOR
Placebo
Intervention Type
DRUG
Capsules
150 mg Active 20d
BMS-984923 150 mg in healthy participants 20 days
Group Type
EXPERIMENTAL
BMS-984923
Intervention Type
DRUG
Capsules
150 mg Placebo 20d
Placebo 150 mg in healthy participants 20 days
Group Type
PLACEBO_COMPARATOR
Placebo
Intervention Type
DRUG
Capsules
50 mg Active-AD
BMS-984923 50 mg
Group Type
EXPERIMENTAL
BMS-984923
Intervention Type
DRUG
Capsules
100 mg Active-AD
BMS-984923 100 mg
Group Type
EXPERIMENTAL
BMS-984923
Intervention Type
DRUG
Capsules
Placebo-AD
Placebo matching
Group Type
PLACEBO_COMPARATOR
Placebo
Intervention Type
DRUG
Capsules
Interventions
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BMS-984923
Capsules
Intervention Type
DRUG
Placebo
Capsules
Intervention Type
DRUG
Other Intervention Names
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Active
Inactive
Eligibility Criteria
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Inclusion Criteria
1. Men or women between the ages of 50 and 80 years, inclusive
2. No history of cognitive impairment
3. Capable of providing written informed consent and willing to comply with all study requirements and procedures
4. Participant is not pregnant, lactating, or of childbearing potential
1. Non-childbearing potential for women is defined as postmenopausal (last natural menses greater than 24 months prior; menopausal status will be documented with serum follicle-stimulating hormone (FSH) or documentation of bilateral tubal ligation or hysterectomy
2. Male participants who are sexually active with a woman of childbearing potential must agree to use condoms during the trial and for 3 months after the last dose unless the woman is using an acceptable means of birth control. Acceptable forms of birth control include abstinence, birth control pills, or any double combination of intrauterine device (IUD), male or female condom, diaphragm, sponge, and cervical cap.
3. Male participants must also agree not to donate sperm for 90 days after the last dose.
5. Montreal Cognitive Assessment (MOCA) \>25
1. Men or women between the ages of 50 and 85 years, inclusive, at the time of first dose of investigational product (IP).
2. Diagnosis of either amnestic mild cognitive impairment (aMCI) or mild dementia due to AD as defined by
* Mild dementia due to AD
* National Institute on Aging (NIA)-Alzheimer's Association core clinical criteria for dementia due to probable AD (McKhann 2011) and,
* Mini Mental Status Exam (MMSE) score between 18 and 26 (inclusive)
* Clinical Dementia Rating (CDR) global score of 0.5 or 1
* aMCI due to AD
* Subjective memory complaint preferably corroborated by an informant and,
* Normal activities of daily living
* CDR global score of 0.5
* aMCI (Petersen 2004) as evidenced by abnormal memory function documented by scoring 1.5 SD below the education adjusted cutoff on the Logical Memory II subscale (Delayed Paragraph Recall) from the Wechsler Memory Scale - Revised (the maximum score is 25), and
* 8 for 16 or more years of education
* 4 for 8 15 years of education
* 2 for 0 7 years of education
3. Stable pharmacological treatment of any other chronic conditions for at least 4 weeks prior to baseline.
2. No history of cognitive impairment
3. Capable of providing written informed consent and willing to comply with all study requirements and procedures
4. Participant is not pregnant, lactating, or of childbearing potential
1. Non-childbearing potential for women is defined as postmenopausal (last natural menses greater than 24 months prior; menopausal status will be documented with serum follicle-stimulating hormone (FSH) or documentation of bilateral tubal ligation or hysterectomy
2. Male participants who are sexually active with a woman of childbearing potential must agree to use condoms during the trial and for 3 months after the last dose unless the woman is using an acceptable means of birth control. Acceptable forms of birth control include abstinence, birth control pills, or any double combination of intrauterine device (IUD), male or female condom, diaphragm, sponge, and cervical cap.
3. Male participants must also agree not to donate sperm for 90 days after the last dose.
5. Montreal Cognitive Assessment (MOCA) \>25
1. Men or women between the ages of 50 and 85 years, inclusive, at the time of first dose of investigational product (IP).
2. Diagnosis of either amnestic mild cognitive impairment (aMCI) or mild dementia due to AD as defined by
* Mild dementia due to AD
* National Institute on Aging (NIA)-Alzheimer's Association core clinical criteria for dementia due to probable AD (McKhann 2011) and,
* Mini Mental Status Exam (MMSE) score between 18 and 26 (inclusive)
* Clinical Dementia Rating (CDR) global score of 0.5 or 1
* aMCI due to AD
* Subjective memory complaint preferably corroborated by an informant and,
* Normal activities of daily living
* CDR global score of 0.5
* aMCI (Petersen 2004) as evidenced by abnormal memory function documented by scoring 1.5 SD below the education adjusted cutoff on the Logical Memory II subscale (Delayed Paragraph Recall) from the Wechsler Memory Scale - Revised (the maximum score is 25), and
* 8 for 16 or more years of education
* 4 for 8 15 years of education
* 2 for 0 7 years of education
3. Stable pharmacological treatment of any other chronic conditions for at least 4 weeks prior to baseline.
Exclusion Criteria
1. Body mass index (BMI) \>38 kg/m2 or body weight \<50 kg.
2. Any significant neurologic disease, such as AD, Parkinson's disease, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma followed by persistent neurologic defaults or known structural brain abnormalities.
3. A current Diagnostic and Statistical Manual of Mental Disorders, Fifth revision (DSM V) diagnosis of active major depression, schizophrenia or bipolar disorder. Participants with depressive symptoms successfully managed by a stable dose of an antidepressant are allowed entry.
4. Positive urine drug screen for amphetamines, barbiturates, benzodiazepines, cocaine, opiates, tetrahydrocannabinol (THC), ethanol or cotinine (stable prescribed amphetamines or benzodiazepines for a non-exclusionary medical condition are permitted) or positive alcohol breathalyzer test
5. Current nicotine use or positive urine cotinine test.
6. History of alcohol or substance abuse or dependence within the past 2 years (DSM IV criteria).
7. Clinically significant or unstable medical condition, including uncontrolled hypertension, uncontrolled diabetes, or significant cardiac, pulmonary, renal, hepatic, endocrine, or other systemic disease in the opinion of the PI, may either put the participant at risk because of participation in the study, or influence the results, or the participant's ability to participate in the study.
8. Any disorder that could interfere with the absorption, distribution, metabolism or excretion of drugs (e.g., small bowel disease, Crohn's disease, celiac disease, or liver disease.)
9. Seropositive for human immunodeficiency virus (HIV).
10. History of acute/chronic hepatitis B or C and/or carriers of hepatitis B (seropositive for hepatitis B surface antigen \[HbsAg\] or anti-hepatitis C \[HCV\] antibody).
11. Use of psychoactive medications (typical neuroleptics, narcotic analgesics, antiparkinsonian medications, systemic corticosteroids, or medications with significant central anticholinergic activity) within 2 weeks or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the trial.
12. Use of medications with potential drug-drug interactions (see Appendix A for a list of these medications) within 2 weeks or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the trial.
13. Use of anticoagulants within 30 days or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the trial.
14. Use of another investigational agent within 30 days or 5 half-lives (whichever is greater) prior to screening and for the duration of the trial.
15. Neutropenia defined as absolute neutrophils count of \<1,500/microliter.
16. Thrombocytopenia defined as platelet count \<100,000/microliter.
17. Clinically significant abnormalities in screening laboratories, including aspartate aminotransferase (AST) \>1.5 times the upper limit of normal (ULN); alanine aminotransferase (ALT) \>1.5 times ULN; total bilirubin \>1.5 times ULN; serum creatinine \>2.0 times ULN.
18. Geriatric Depression Scale (GDS) score of ≥5 and symptoms consistent with a current episode of major depression.
5. Study partner is available who has frequent contact with the participant (e.g., average of 10 hours per week or more), and can participate in all study partner assessments for the duration of the protocol.
6. Generally healthy with mobility (ambulatory or ambulatory-aided, i.e., walker or cane), vision and hearing (hearing aid permissible) sufficient for compliance with testing procedures as determined by the PI.
7. Must be able to complete all screening evaluations
8. Living at home or in the community (assisted living acceptable)
9. Ability to swallow study medication.
10. Modified Hachinski score ≤4
11. Capable of providing written informed consent and willing to comply with all study requirements and procedures
12. Participant is not pregnant, lactating, or of childbearing potential
* Non-childbearing potential for women is defined as postmenopausal (last natural menses greater than 24 months prior; menopausal status will be documented with serum FSH or documentation of bilateral tubal ligation or hysterectomy
* Male participants who are sexually active with a woman of childbearing potential must agree to use condoms during the trial and for 3 months after the last dose unless the woman is using an acceptable means of birth control. Acceptable forms of birth control include abstinence, birth control pills, or any double combination of IUD, male or female condom, diaphragm, sponge, and cervical cap.
* Male participants must also agree not to donate sperm for 90 days after the last dose.
1. Hospitalization or change of chronic concomitant medication within 4 weeks prior to baseline
2. BMI \>38 kg/m2 or body weight \<50 kg
3. Any contraindications for MRI studies, such as claustrophobia, the presence of metal (ferromagnetic) implants, metal fragments or foreign objects in the eyes, skin, or body or a cardiac pacemaker.
4. Living in a continuous care nursing facility
5. Screening MRI of the brain indicative of significant abnormality, including, but not limited to, prior hemorrhage or infarct \>1 cm3, \>3 lacunar infarcts, cerebral contusion, encephalomalacia, aneurysm, vascular malformation, subdural hematoma, hydrocephalus, or space-occupying lesion (e.g., abscess or brain tumor such as meningioma)
6. Clinical or laboratory findings consistent with:
* Other primary neurodegenerative disease or cognitive disorder (Lewy body disease, frontotemporal lobar disease, Huntington's disease, Jacob-Creutzfeld Disease, Down's syndrome, Parkinson's disease, amyotrophic lateral sclerosis, etc.)
* Seizure disorder
* Other infectious, metabolic or systemic diseases affecting the central nervous system (syphilis, present hypothyroidism, present vitamin B12 deficiency, other laboratory abnormalities, etc.)
7. A current DSM V diagnosis of active major depression, schizophrenia or bipolar disorder. Participants with depressive symptoms successfully managed by a stable dose of an antidepressant are allowed entry.
8. Clinically significant or unstable medical condition, including uncontrolled hypertension, uncontrolled diabetes, or significant cardiac, pulmonary, renal, hepatic, endocrine, or other systemic disease that in the opinion of the PI, may either put the participant at risk because of participation in the study, or influence the results, or impair the participant's ability to participate in the study.
9. Disability that may prevent the participant from completing all study requirements (e.g., blindness, deafness, severe language difficulty, etc.)
10. Any disorder that could interfere with the absorption, distribution, metabolism or excretion of drugs (e.g., small bowel disease, Crohn's disease, celiac disease, or liver disease.)
11. Nootropic drugs except stable AD meds (acetylcholinesterase inhibitors and memantine) for 12 weeks prior to baseline
12. History of alcohol or substance abuse or dependence within the past 2 years (DSM IV criteria).
13. Suspected or known allergy to any components of the study treatments
14. Any condition, which in the opinion of the investigator or Project Director (PD) makes the participant unsuitable for inclusion
15. Clinically significant abnormalities in B12 or thyroid function tests (TFTs) that might interfere with the study
16. Use of psychoactive medications (typical neuroleptics, narcotic analgesics, antiparkinsonian medications, systemic corticosteroids, or medications with significant central anticholinergic activity) within 2 weeks or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the trial
17. Use of medications with potential drug-drug interactions (see Appendix A for a list of these medications) within 2 weeks or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the trial.
18. Use of anticoagulants within 30 days or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the trial
19. Use of investigational amyloid lowering therapies within 2 months prior to study drug administration and for the duration of the trial.
20. Use of another investigational agent within 30 days or 5 half-lives (whichever is greater) prior to screening and for the duration of the trial
21. Neutropenia defined as absolute neutrophils count of \<1,500/microliter
22. Thrombocytopenia defined as platelet count \<100,000/microliter.
23. Clinically significant abnormalities in screening laboratories, including AST \>1.5 times ULN; ALT \>1.5 times ULN; total bilirubin \>1.5 times ULN; serum creatinine \>2.0 times ULN
24. GDS score of ≥5 and symptoms consistent with a current episode of major depression.
2. Any significant neurologic disease, such as AD, Parkinson's disease, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma followed by persistent neurologic defaults or known structural brain abnormalities.
3. A current Diagnostic and Statistical Manual of Mental Disorders, Fifth revision (DSM V) diagnosis of active major depression, schizophrenia or bipolar disorder. Participants with depressive symptoms successfully managed by a stable dose of an antidepressant are allowed entry.
4. Positive urine drug screen for amphetamines, barbiturates, benzodiazepines, cocaine, opiates, tetrahydrocannabinol (THC), ethanol or cotinine (stable prescribed amphetamines or benzodiazepines for a non-exclusionary medical condition are permitted) or positive alcohol breathalyzer test
5. Current nicotine use or positive urine cotinine test.
6. History of alcohol or substance abuse or dependence within the past 2 years (DSM IV criteria).
7. Clinically significant or unstable medical condition, including uncontrolled hypertension, uncontrolled diabetes, or significant cardiac, pulmonary, renal, hepatic, endocrine, or other systemic disease in the opinion of the PI, may either put the participant at risk because of participation in the study, or influence the results, or the participant's ability to participate in the study.
8. Any disorder that could interfere with the absorption, distribution, metabolism or excretion of drugs (e.g., small bowel disease, Crohn's disease, celiac disease, or liver disease.)
9. Seropositive for human immunodeficiency virus (HIV).
10. History of acute/chronic hepatitis B or C and/or carriers of hepatitis B (seropositive for hepatitis B surface antigen \[HbsAg\] or anti-hepatitis C \[HCV\] antibody).
11. Use of psychoactive medications (typical neuroleptics, narcotic analgesics, antiparkinsonian medications, systemic corticosteroids, or medications with significant central anticholinergic activity) within 2 weeks or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the trial.
12. Use of medications with potential drug-drug interactions (see Appendix A for a list of these medications) within 2 weeks or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the trial.
13. Use of anticoagulants within 30 days or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the trial.
14. Use of another investigational agent within 30 days or 5 half-lives (whichever is greater) prior to screening and for the duration of the trial.
15. Neutropenia defined as absolute neutrophils count of \<1,500/microliter.
16. Thrombocytopenia defined as platelet count \<100,000/microliter.
17. Clinically significant abnormalities in screening laboratories, including aspartate aminotransferase (AST) \>1.5 times the upper limit of normal (ULN); alanine aminotransferase (ALT) \>1.5 times ULN; total bilirubin \>1.5 times ULN; serum creatinine \>2.0 times ULN.
18. Geriatric Depression Scale (GDS) score of ≥5 and symptoms consistent with a current episode of major depression.
5. Study partner is available who has frequent contact with the participant (e.g., average of 10 hours per week or more), and can participate in all study partner assessments for the duration of the protocol.
6. Generally healthy with mobility (ambulatory or ambulatory-aided, i.e., walker or cane), vision and hearing (hearing aid permissible) sufficient for compliance with testing procedures as determined by the PI.
7. Must be able to complete all screening evaluations
8. Living at home or in the community (assisted living acceptable)
9. Ability to swallow study medication.
10. Modified Hachinski score ≤4
11. Capable of providing written informed consent and willing to comply with all study requirements and procedures
12. Participant is not pregnant, lactating, or of childbearing potential
* Non-childbearing potential for women is defined as postmenopausal (last natural menses greater than 24 months prior; menopausal status will be documented with serum FSH or documentation of bilateral tubal ligation or hysterectomy
* Male participants who are sexually active with a woman of childbearing potential must agree to use condoms during the trial and for 3 months after the last dose unless the woman is using an acceptable means of birth control. Acceptable forms of birth control include abstinence, birth control pills, or any double combination of IUD, male or female condom, diaphragm, sponge, and cervical cap.
* Male participants must also agree not to donate sperm for 90 days after the last dose.
1. Hospitalization or change of chronic concomitant medication within 4 weeks prior to baseline
2. BMI \>38 kg/m2 or body weight \<50 kg
3. Any contraindications for MRI studies, such as claustrophobia, the presence of metal (ferromagnetic) implants, metal fragments or foreign objects in the eyes, skin, or body or a cardiac pacemaker.
4. Living in a continuous care nursing facility
5. Screening MRI of the brain indicative of significant abnormality, including, but not limited to, prior hemorrhage or infarct \>1 cm3, \>3 lacunar infarcts, cerebral contusion, encephalomalacia, aneurysm, vascular malformation, subdural hematoma, hydrocephalus, or space-occupying lesion (e.g., abscess or brain tumor such as meningioma)
6. Clinical or laboratory findings consistent with:
* Other primary neurodegenerative disease or cognitive disorder (Lewy body disease, frontotemporal lobar disease, Huntington's disease, Jacob-Creutzfeld Disease, Down's syndrome, Parkinson's disease, amyotrophic lateral sclerosis, etc.)
* Seizure disorder
* Other infectious, metabolic or systemic diseases affecting the central nervous system (syphilis, present hypothyroidism, present vitamin B12 deficiency, other laboratory abnormalities, etc.)
7. A current DSM V diagnosis of active major depression, schizophrenia or bipolar disorder. Participants with depressive symptoms successfully managed by a stable dose of an antidepressant are allowed entry.
8. Clinically significant or unstable medical condition, including uncontrolled hypertension, uncontrolled diabetes, or significant cardiac, pulmonary, renal, hepatic, endocrine, or other systemic disease that in the opinion of the PI, may either put the participant at risk because of participation in the study, or influence the results, or impair the participant's ability to participate in the study.
9. Disability that may prevent the participant from completing all study requirements (e.g., blindness, deafness, severe language difficulty, etc.)
10. Any disorder that could interfere with the absorption, distribution, metabolism or excretion of drugs (e.g., small bowel disease, Crohn's disease, celiac disease, or liver disease.)
11. Nootropic drugs except stable AD meds (acetylcholinesterase inhibitors and memantine) for 12 weeks prior to baseline
12. History of alcohol or substance abuse or dependence within the past 2 years (DSM IV criteria).
13. Suspected or known allergy to any components of the study treatments
14. Any condition, which in the opinion of the investigator or Project Director (PD) makes the participant unsuitable for inclusion
15. Clinically significant abnormalities in B12 or thyroid function tests (TFTs) that might interfere with the study
16. Use of psychoactive medications (typical neuroleptics, narcotic analgesics, antiparkinsonian medications, systemic corticosteroids, or medications with significant central anticholinergic activity) within 2 weeks or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the trial
17. Use of medications with potential drug-drug interactions (see Appendix A for a list of these medications) within 2 weeks or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the trial.
18. Use of anticoagulants within 30 days or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the trial
19. Use of investigational amyloid lowering therapies within 2 months prior to study drug administration and for the duration of the trial.
20. Use of another investigational agent within 30 days or 5 half-lives (whichever is greater) prior to screening and for the duration of the trial
21. Neutropenia defined as absolute neutrophils count of \<1,500/microliter
22. Thrombocytopenia defined as platelet count \<100,000/microliter.
23. Clinically significant abnormalities in screening laboratories, including AST \>1.5 times ULN; ALT \>1.5 times ULN; total bilirubin \>1.5 times ULN; serum creatinine \>2.0 times ULN
24. GDS score of ≥5 and symptoms consistent with a current episode of major depression.
Minimum Eligible Age
50 Years
Maximum Eligible Age
80 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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Yale University
OTHER
Sponsor Role
collaborator
National Institute on Aging (NIA)
NIH
Sponsor Role
collaborator
Allyx Therapeutics
INDUSTRY
Sponsor Role
lead
Responsible Party
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Responsibility Role
SPONSOR
Principal Investigators
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Adam Mecca, MD, PhD
Role: STUDY_DIRECTOR
Yale University
Stephanie Post, MD
Role: PRINCIPAL_INVESTIGATOR
Spaulding Clinical Research (Stage 1)
Adam Mecca, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Yale University (Stage 2)
Locations
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Yale University
New Haven, Connecticut, United States
Site Status
Spaulding Clinical Research
West Bend, Wisconsin, United States
Site Status
Countries
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United States
References
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Haas LT, Salazar SV, Smith LM, Zhao HR, Cox TO, Herber CS, Degnan AP, Balakrishnan A, Macor JE, Albright CF, Strittmatter SM. Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes. Cell Rep. 2017 Jul 5;20(1):76-88. doi: 10.1016/j.celrep.2017.06.023.
Reference Type
BACKGROUND
Spurrier J, Nicholson L, Fang XT, Stoner AJ, Toyonaga T, Holden D, Siegert TR, Laird W, Allnutt MA, Chiasseu M, Brody AH, Takahashi H, Nies SH, Perez-Canamas A, Sadasivam P, Lee S, Li S, Zhang L, Huang YH, Carson RE, Cai Z, Strittmatter SM. Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q. Sci Transl Med. 2022 Jun;14(647):eabi8593. doi: 10.1126/scitranslmed.abi8593. Epub 2022 Jun 1.
Reference Type
BACKGROUND
Other Identifiers
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ALX-923-102
Identifier Type: -
Identifier Source: org_study_id