A Study to Assess the Effects of CT-868 Treatment on Glucose Homeostasis in Participants with Type 1 Diabetes

NCT ID: NCT05794581

Last Updated: 2024-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-03-21

Study Completion Date

2024-04-06

Brief Summary

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This study will be conducted primarily to evaluate the effects of CT-868 on glucose homeostasis in participants with Type 1 Diabetes Mellitus.

Detailed Description

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Conditions

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Type 1 Diabetes

Keywords

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Type 1 Diabetes Obesity Overweight

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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CT-868

SC injection of CT-868 Intervention

Group Type EXPERIMENTAL

CT-868

Intervention Type DRUG

CT-868

Placebo

SC injection of placebo matching CT-868 dose

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo as SC Injection

Victoza

SC injection of active comparator

Group Type ACTIVE_COMPARATOR

Victoza

Intervention Type DRUG

Victoza as active comparator as SC Injection

Interventions

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CT-868

CT-868

Intervention Type DRUG

Placebo

Placebo as SC Injection

Intervention Type DRUG

Victoza

Victoza as active comparator as SC Injection

Intervention Type DRUG

Other Intervention Names

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Liraglutide

Eligibility Criteria

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Inclusion Criteria

* Female or male adults with Type 1 diabetes
* Ages 18-65 years
* Type 1 DM for at least 3 years
* Using an insulin pump or multiple daily injections (MDI) for at least 3 months
* BMI 25.0 - 35.0

Exclusion Criteria

* Significant medical history
* Uncontrolled diabetes
* History of surgical treatment for weight loss
* History of malignancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Carmot Therapeutics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Carmot Clinical Research Unit 101

Chula Vista, California, United States

Site Status

Countries

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United States

Related Links

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https://carmot-therapeutics.us/

Carmot Therapeutics, Inc.

Other Identifiers

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CT-868-005

Identifier Type: -

Identifier Source: org_study_id