Wenzhou Gestational Diabetes Cohort

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-03-21

Study Completion Date

2033-03-21

Brief Summary

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The Wenzhou Gestational Diabetes Cohort (WGDC) is a prospective cohort study among women with gestational diabetes mellitus (GDM) during pregnancy and their offspring living in Wenzhou, China. The primary aim of this cohort is to characterize the continuous blood glucose response to dietary intake and physical activity among pregnant women with GDM over 2 weeks, and to facilitate the development of personalized nutritional/lifestyle recommendation among these patients. Another aim of the WGDC is to investigate the association of dietary and physical activity together with continuous glucose change during pregnancy on the adverse birth outcomes including preterm birth, macrosomia and large-for-gestational-age birth. The secondary aim is to investigate the prospective associations of diet, physical activity and continuous glucose change over 2 weeks among the patients with long-term metabolic health of the women and their offspring.

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Detailed Description

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In China, an alarming increase in the prevalence of GDM has been observed in the past decade. GDM is of concern because it is associated with several maternal and fetal medical disorders. Lifestyle changes such as diet and physical activity modifications are key for the prevention and treatment of GDM. However, the associations between dietary intake and physical activity and health outcomes for GDM women and their children remain unclear due to subjective measurements of diet and physical activity. Recently, the development of objective measurements such as food image identification and wearable activity trackers give an opportunity to gain more precise insight into these associations. In addition, for the same food and physical activity exposure, GDM women may have different blood glucose responses, but the nature of variation is currently poorly characterized. Therefore, the present WGDC design incorporates three unique components, 1) objective measurement of physical activity during pregnancy using accelerometer; 2) measurement of dietary intake using both Food Frequency Questionnaire and daily dietary records; 3) measurement of blood glucose levels over 2 weeks using continuous glucose monitors, with three standardized test meals during the 2 weeks. We will then follow up these women participants during and after this pregnancy, and also follow up their offspring.

Conditions

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Gestational Diabetes Mellitus Intrauterine Hyperglycemia Birth Outcome, Adverse Nutrition, Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Standardized breakfast

Egg (50g), whole-wheat bread (35g), celery (30g), and dried bean curd (10g)

Group Type OTHER

Standardized breakfast

Intervention Type OTHER

Participants will be provided with a standardized breakfast on a morning of the days they wear a continuous glucose monitoring (CGM) device.

Standardized snack

Tomato (50g) and skim milk (200g)

Group Type OTHER

Standardized snack

Intervention Type OTHER

Participants will be provided with a standardized snack 2 hour after they have the standardized breakfast.

Standardized lunch

Rice (40g), oats (40g), shrimp (70g), lettuce (80g), lean pork (30g), carrot (10g), soaked auricularia auricula (20g), broccoli (80g), cucumber (10g), tomato egg drop soup (200g), salt (3g), and oil (8g)

Group Type OTHER

Standardized lunch

Intervention Type OTHER

Participants will be provided with a standardized lunch 2 h after they have the standardized snack.

Interventions

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Standardized breakfast

Participants will be provided with a standardized breakfast on a morning of the days they wear a continuous glucose monitoring (CGM) device.

Intervention Type OTHER

Standardized snack

Participants will be provided with a standardized snack 2 hour after they have the standardized breakfast.

Intervention Type OTHER

Standardized lunch

Participants will be provided with a standardized lunch 2 h after they have the standardized snack.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Women aged 18 years or older
* Women with GDM mainly at 24-28 weeks of gestation
* Women intended to deliver at Wenzhou People's Hospital
* Women intended to remain in Wenzhou with their child for ≥4 years