Pregnancy-associated Progression of Chronic Kidney Disease: A Study Protocol for the Development and Validation of a Clinical Predictive Tool
NCT ID: NCT05793346
Last Updated: 2023-03-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
5000 participants
OBSERVATIONAL
2023-03-31
2023-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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OTHER
RETROSPECTIVE
Study Groups
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Dataset 1: National Registry of Rare Kidney Diseases
This dataset is the: National Registry of Rare Kidney Diseases from the UK Renal Registry, this is a UK-wide, linked dataset. This cohort includes any woman who has previously had a previous diagnosis of kidney disease in the UK with maternity records and who has consented to participate.
No interventions assigned to this group
Dataset 2: Kent Integrated Data
Maternal and laboratory data from East and West Kent in the UK.
No interventions assigned to this group
Dataset 3: Stockholm Creatinine Measurement
An observational dataset with laboratory data from individuals in Stockholm (Sweden)
No interventions assigned to this group
Dataset 4: Ontario Renal Network Pregnancy Cohort
A population-based cohort of women in Ontario who had an obstetric delivery with outpatient laboratory data.
No interventions assigned to this group
Dataset 5: Combined cohort of three obstetric studies within the UK
A combined cohort derived from three obstetric studies within the UK.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Multi-fetal pregnancies
* Known inpatient eGFR measurement
* No preconception eGFR within 24 months will be excluded.
18 Years
50 Years
FEMALE
No
Sponsors
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King's College London
OTHER
Responsible Party
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References
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Wiles K, Webster P, Seed PT, Bennett-Richards K, Bramham K, Brunskill N, Carr S, Hall M, Khan R, Nelson-Piercy C, Webster LM, Chappell LC, Lightstone L. The impact of chronic kidney disease Stages 3-5 on pregnancy outcomes. Nephrol Dial Transplant. 2021 Nov 9;36(11):2008-2017. doi: 10.1093/ndt/gfaa247.
Tong A, Jesudason S, Craig JC, Winkelmayer WC. Perspectives on pregnancy in women with chronic kidney disease: systematic review of qualitative studies. Nephrol Dial Transplant. 2015 Apr;30(4):652-61. doi: 10.1093/ndt/gfu378. Epub 2014 Dec 18.
Piccoli GB, Zakharova E, Attini R, Ibarra Hernandez M, Orozco Guillien A, Alrukhaimi M, Liu ZH, Ashuntantang G, Covella B, Cabiddu G, Li PKT, Garcia-Garcia G, Levin A. Pregnancy in Chronic Kidney Disease: Need for Higher Awareness. A Pragmatic Review Focused on What Could Be Improved in the Different CKD Stages and Phases. J Clin Med. 2018 Nov 5;7(11):415. doi: 10.3390/jcm7110415.
Other Identifiers
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PREDICT_Protocol_V1
Identifier Type: -
Identifier Source: org_study_id