Developing an Integrated Psychotherapy With Cognitive-behavioral Therapy and Biofeedback Therapy for Somatic Symptom Disorder

NCT ID: NCT05792930

Last Updated: 2025-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-07-11

Study Completion Date

2026-06-30

Brief Summary

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This research program is aimed to develop a integrative psychotherapy (including CBT and biofeedback therapy) and to examine its efficacy on treatment of somatic symptom disorder. The study design is a randomized controlled trial with waiting list control. Scores of Patient Health Questionniare-15 and Health Anxiety Questionnaire are the primary endpoints.

Detailed Description

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Somatic symptom disorder (SSD) is a psychiatric disorder featured with somatic distress and related psychological phenomena. In the past several years, our research team has investigated several aspects of SSD, including psychopathology, epidemiology, mechanism, and diagnostic biomarkers. But the aspect about treatment on SSD has not been comprehensively explored.

In literature, the treatment of SSD can be separated into physical and psychological approaches. The physical approach includes pharmacotherapy and magnetic/electrical neuromodulation. Among several types of psychotherapies, cognitive behavioral therapy (CBT) has the most evidence. Previous studies have disclosed SSD patients to have following cognitive or behavioral features: selective attention on somatic distress; memory bias on the severe health conditions; all-or-none cognition about health; organic attribution style; catastrophizing cognitive pattern about health; high motivation of concerning issues about health; inadequate reassurance-seeking behavior; the assumption about the connection between rest and somatic distress, etc.

Biofeedback therapy works by measuring several biological signals related with stress and relaxation (such as heart rate, skin conductance, electromyography, electroencephalography, and finger temperature); feedback of these signals to the subjects can help them more clearly understand the association between their behavior/cognition and relaxation. Biofeedback therapy has been extensively applied in the psychosomatic field.

This research program is aimed to develop a integrative psychotherapy (including CBT and biofeedback therapy) and to examine its efficacy. The study design is a randomized controlled trial with waiting list control. Scores of Patient Health Questionniare-15 (PHQ-15) and Health Anxiety Questionnaire (HAQ) are the primary endpoints; the changes of other psychological and biological measurements are viewed as secondary endpoints.

Conditions

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Somatic Symptom Disorder

Keywords

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somatic symptom disorder cognitive behavioral therapy biofeedback therapy somatic distress health anxiety

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Experimental Group

The experimental group will receive cognitive-behavioral therapy (CBT) and biofeedback therapy.

Group Type EXPERIMENTAL

cognitive-behavioral therapy and biofeedback therapy

Intervention Type BEHAVIORAL

Complete eight sessions of cognitive-behavioral therapy and biofeedback therapy within three months.

Control Group

The design of control group is waiting list control; their data will be collected without intervention during the observation period. After the observation period, psychotherapy (CBT and biofeedback, the same as intervention) will be arranged.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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cognitive-behavioral therapy and biofeedback therapy

Complete eight sessions of cognitive-behavioral therapy and biofeedback therapy within three months.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Patient with somatic symptom disorder (confirmed by psychiatrists)

Exclusion Criteria

* The age is younger than 20 or older than 70 years
* Having psychotic symptoms or cognitive impairment
* Having a potentially lethal illness
* Cannot read the questionnaires by oneself
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wei-Lieh Huang, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

National Taiwan University Hospital

Locations

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Department of Psychiatry, National Taiwan University Hospital Yunlin Branch

Yunlin, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Wei-Lieh Huang, MD, PhD

Role: CONTACT

Phone: 886-5-5323911

Email: [email protected]

Facility Contacts

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Huang Wei-Lieh, MD, MSc, PhD

Role: primary

Other Identifiers

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202209093RIND

Identifier Type: -

Identifier Source: org_study_id