Safety and Efficacy of DIDALA Monotherapy in Patients With Type 2 Diabetes Compared With Metformin.

NCT ID: NCT05760456

Last Updated: 2023-03-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

140 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-03-15

Study Completion Date

2024-08-31

Brief Summary

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This is an open-label, two-group parallel study, comparing before and after treatment within the same group and between the two groups. This study is designed to collect data on the safety and efficacy of a marketed pharmaceutical product (DIDALA) compared with Metformin. The efficacy data of DIDALA will be directly compared with Metformin 1000mg/day monotherapy in this study.

Detailed Description

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Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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DIDALA

DIDALA is a herbal medicine, produced from dried mulberry leaves. The drug has been approved by the Drug Administration of Vietnam.

Group Type EXPERIMENTAL

DIDALA hard capsules

Intervention Type DRUG

DIDALA is given orally with a dose of 2 capsules, 3 times per day for 12 weeks

METFORMIN

Group Type ACTIVE_COMPARATOR

Metformin

Intervention Type DRUG

Metformin 500mg, 1 tablet twice a day, immediately after breakfast and dinner for 12 weeks

Interventions

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DIDALA hard capsules

DIDALA is given orally with a dose of 2 capsules, 3 times per day for 12 weeks

Intervention Type DRUG

Metformin

Metformin 500mg, 1 tablet twice a day, immediately after breakfast and dinner for 12 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 18 years or older at the time of enrollment in the study.
* Diagnosed with type 2 diabetes according to the Guidelines for the diagnosis of type 2 diabetes of the Ministry of Health (2011).
* Fasting blood glucose ≤ 10.0 mmol/L.
* No previous treatment with metformin or other antidiabetic drugs.
* Ability and willingness to provide written informed consent and comply with the protocol's requirements.
* Subject who, in the judgment of the Investigator, is likely to be compliant or cooperative during the study.

Exclusion Criteria

* The patient has been diagnosed with diabetes and has been previously treated with metformin or other antidiabetic agents.
* Patients with indications for insulin therapy or combination therapy of two or more drugs according to the guidelines for diagnosis and treatment of type 2 diabetes of the Ministry of Health.
* Pregnancy or lactation.
* Patients with contraindications to Metformin include severe liver and/or kidney disease, congestive heart failure, cardiovascular collapse, acute myocardial infarction, severe infection, and sepsis.
* Patients with conditions and circumstances that, in the investigator's opinion, are difficult to ensure adherence to study protocol.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre of Clinical Pharmacology, Hanoi Medical University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hanoi Hospital of Traditional Medical

Hanoi, , Vietnam

Site Status

National Hospital of Traditional Medicine

Hanoi, , Vietnam

Site Status

Countries

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Vietnam

Central Contacts

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Centre of Clinical Pharmacology

Role: CONTACT

+84 24 3852 3798 ext. 3188

Facility Contacts

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Hanoi Hospital of Traditional Medical

Role: primary

+84 24 37684059

National Hospital of Traditional Medicine

Role: primary

84-4-3826361

Other Identifiers

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V5.0 08.08.2022

Identifier Type: -

Identifier Source: org_study_id

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