SUper-Resolution Ultrasound Imaging of Erythrocytes (SURE) in Normal and Malignant Lymph Nodes
NCT ID: NCT05754814
Last Updated: 2025-05-15
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
RECRUITING
Total Enrollment
100 participants
Study Classification
OBSERVATIONAL
Study Start Date
2022-06-28
Study Completion Date
2026-04-30
Brief Summary
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The goal of this observational study is to visualize the small vessels in normal and cancerous lymph nodes on the neck with a new ultrasound technique.
The main questions it aims to answer are:
* Is it possible to visualize the network of the smallest vessels in lymph nodes on the neck?
* Is it possible to distinguish between healthy and cancerous lymph nodes using different parameters?
The participants will have 1-2 lymph nodes ultrasound scanned with a standard ultrasound technique and the new technique.
The main questions it aims to answer are:
* Is it possible to visualize the network of the smallest vessels in lymph nodes on the neck?
* Is it possible to distinguish between healthy and cancerous lymph nodes using different parameters?
The participants will have 1-2 lymph nodes ultrasound scanned with a standard ultrasound technique and the new technique.
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Detailed Description
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Super-resolution ultrasound using erythrocytes (SURE) is a new ultrasound technique for visualizing the very small blood vessels in the body. The technique uses tracking of the blood's red blood cells (erythrocytes) to achieve a higher resolution of the blood vessels' shape, structure, and blood flow. The technique makes it possible to create images with much higher resolution than normal ultrasound, which means that even very small blood vessels can be imaged and measured.
In many diseases, the small blood vessels change their function or structure. One of the major disease groups where SURE has significant potential is cancer. In cancerous nodes, the small blood vessels change: they become twisted, irregular, and function poorly. If changes in the small vessels can be detected at an early stage using SURE, it can lead to quicker diagnoses and better evaluations of the effectiveness of treatment.
In this study, the investigators aim to demonstrate the practical feasibility of SURE imaging in human lymph nodes and investigate the clinical relevance of SURE imaging in the diagnosis of malignant lymph nodes by comparing lymph nodes from healthy participants with lymph nodes from participants with head and neck cancer metastases or lymphoma.
In many diseases, the small blood vessels change their function or structure. One of the major disease groups where SURE has significant potential is cancer. In cancerous nodes, the small blood vessels change: they become twisted, irregular, and function poorly. If changes in the small vessels can be detected at an early stage using SURE, it can lead to quicker diagnoses and better evaluations of the effectiveness of treatment.
In this study, the investigators aim to demonstrate the practical feasibility of SURE imaging in human lymph nodes and investigate the clinical relevance of SURE imaging in the diagnosis of malignant lymph nodes by comparing lymph nodes from healthy participants with lymph nodes from participants with head and neck cancer metastases or lymphoma.
Conditions
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Head and Neck Cancer
Lymphoma
Lymph Node Metastasis
Study Design
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Observational Model Type
CASE_CONTROL
Study Time Perspective
CROSS_SECTIONAL
Study Groups
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Controls
Healthy participants
No interventions assigned to this group
Cases
Patients with malignant lymph nodes on the neck
Malignant lymph nodes
Intervention Type
OTHER
Patients with a condition; either lymphoma on the neck or head and neck cancer with lymph node metastases on the neck.
Interventions
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Malignant lymph nodes
Patients with a condition; either lymphoma on the neck or head and neck cancer with lymph node metastases on the neck.
Intervention Type
OTHER
Eligibility Criteria
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Inclusion Criteria
* Participants must be 18 to 70 years of age, at the time of signing the informed consent
* Participants who can lie still for 1 minute
* Capable of giving signed informed consent
* Participants who are overtly healthy as determined by medical history
* Participants who have a superficial lymph node laterally on the neck with a normal appearance on standard B-mode ultrasound available for SURE imaging
* Participants who, besides their untreated head and neck cancer or lymphoma, are overtly healthy as determined by medical evaluation and medical history
* Participants with untreated lymphoma or head and neck cancer and lymph node metastasis verified by a biopsy.
* Participants who have superficial lymph nodes laterally on the neck up to 2.5 cm (so the entire lymph node is in the SURE image)
* Participants who will have their lymph nodes surgically removed
* Participants who can lie still for 1 minute
* Capable of giving signed informed consent
* Participants who are overtly healthy as determined by medical history
* Participants who have a superficial lymph node laterally on the neck with a normal appearance on standard B-mode ultrasound available for SURE imaging
* Participants who, besides their untreated head and neck cancer or lymphoma, are overtly healthy as determined by medical evaluation and medical history
* Participants with untreated lymphoma or head and neck cancer and lymph node metastasis verified by a biopsy.
* Participants who have superficial lymph nodes laterally on the neck up to 2.5 cm (so the entire lymph node is in the SURE image)
* Participants who will have their lymph nodes surgically removed
Exclusion Criteria
* Pregnancy
* Dementia
* Physique making ultrasound scanning difficult
* Ongoing or recent (within the last 4 weeks) infectious disease (bacterial, viral, fungal, or protozoal) which may give rise to reactive lymph nodes
* Diseases that cause lymphadenopathy: Some chronic infectious diseases (HIV, Tuberculosis, Hepatitis B), Systemic diseases (rheumatoid arthritis, systemic lupus erythematosus, sarcoidosis, other rare systemic diseases\*), Primary adrenal insufficiency (Addison´s disease), Leukemia, Lymphoma or other cancers (besides the type of cancer the participant is being examined for at the Department of Otorhinolaryngology, Head and Neck Surgery \& Audiology, Rigshospitalet)
* Drugs that cause lymphadenopathy: Antibiotics (Cephalosporins, Penicillin, Sulfonamides), Antiepileptics (Carbamazepine, Ethosuximide, Lamotrigine, Phenytoin, Primidone), Antihypertensives (Atenolol, Captopril, Hydralazine), Other (Allopurinol, Imatinib)
* Castleman's disease, Kikuchi's disease, Kawasaki disease, Inflammatory pseudotumor, Amyloidosis, Kimura disease, Rosai-Dorfman disease, IgG4-related disease, Still's disease, dermatomyositis, Churg-Strauss, histiocytosis, chronic granulomatous diseases, Autoimmune lymphoproliferative syndrome, lipid storage diseases.
* Dementia
* Physique making ultrasound scanning difficult
* Ongoing or recent (within the last 4 weeks) infectious disease (bacterial, viral, fungal, or protozoal) which may give rise to reactive lymph nodes
* Diseases that cause lymphadenopathy: Some chronic infectious diseases (HIV, Tuberculosis, Hepatitis B), Systemic diseases (rheumatoid arthritis, systemic lupus erythematosus, sarcoidosis, other rare systemic diseases\*), Primary adrenal insufficiency (Addison´s disease), Leukemia, Lymphoma or other cancers (besides the type of cancer the participant is being examined for at the Department of Otorhinolaryngology, Head and Neck Surgery \& Audiology, Rigshospitalet)
* Drugs that cause lymphadenopathy: Antibiotics (Cephalosporins, Penicillin, Sulfonamides), Antiepileptics (Carbamazepine, Ethosuximide, Lamotrigine, Phenytoin, Primidone), Antihypertensives (Atenolol, Captopril, Hydralazine), Other (Allopurinol, Imatinib)
* Castleman's disease, Kikuchi's disease, Kawasaki disease, Inflammatory pseudotumor, Amyloidosis, Kimura disease, Rosai-Dorfman disease, IgG4-related disease, Still's disease, dermatomyositis, Churg-Strauss, histiocytosis, chronic granulomatous diseases, Autoimmune lymphoproliferative syndrome, lipid storage diseases.
Minimum Eligible Age
18 Years
Maximum Eligible Age
70 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
Yes
Sponsors
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Technical University of Denmark
OTHER
Sponsor Role
collaborator
University of Copenhagen
OTHER
Sponsor Role
collaborator
Rigshospitalet, Denmark
OTHER
Sponsor Role
lead
Responsible Party
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Nathalie Sarup Panduro
Principal Investigator
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
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Nathalie Sarup Panduro, MD
Role: PRINCIPAL_INVESTIGATOR
The Department of Diagnostic Radiology, Rigshospitalet
Locations
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Rigshospitalet
Copenhagen, Capital Region, Denmark
Site Status
RECRUITING
Technical University of Denmark
Kongens Lyngby, Capital Region, Denmark
Site Status
RECRUITING
Countries
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Denmark
Central Contacts
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Facility Contacts
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References
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Corliss BA, Mathews C, Doty R, Rohde G, Peirce SM. Methods to label, image, and analyze the complex structural architectures of microvascular networks. Microcirculation. 2019 Jul;26(5):e12520. doi: 10.1111/micc.12520. Epub 2019 Jan 17.
Reference Type
BACKGROUND
Demene C, Robin J, Dizeux A, Heiles B, Pernot M, Tanter M, Perren F. Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients. Nat Biomed Eng. 2021 Mar;5(3):219-228. doi: 10.1038/s41551-021-00697-x. Epub 2021 Mar 15.
Reference Type
BACKGROUND
Chen Q, Yu J, Rush BM, Stocker SD, Tan RJ, Kim K. Ultrasound super-resolution imaging provides a noninvasive assessment of renal microvasculature changes during mouse acute kidney injury. Kidney Int. 2020 Aug;98(2):355-365. doi: 10.1016/j.kint.2020.02.011. Epub 2020 Mar 3.
Reference Type
BACKGROUND
Christensen-Jeffries K, Browning RJ, Tang MX, Dunsby C, Eckersley RJ. In vivo acoustic super-resolution and super-resolved velocity mapping using microbubbles. IEEE Trans Med Imaging. 2015 Feb;34(2):433-40. doi: 10.1109/TMI.2014.2359650. Epub 2014 Sep 23.
Reference Type
BACKGROUND
Demidov V, Maeda A, Sugita M, Madge V, Sadanand S, Flueraru C, Vitkin IA. Preclinical longitudinal imaging of tumor microvascular radiobiological response with functional optical coherence tomography. Sci Rep. 2018 Jan 8;8(1):38. doi: 10.1038/s41598-017-18635-w.
Reference Type
BACKGROUND
Dencks S, Piepenbrock M, Opacic T, Krauspe B, Stickeler E, Kiessling F, Schmitz G. Clinical Pilot Application of Super-Resolution US Imaging in Breast Cancer. IEEE Trans Ultrason Ferroelectr Freq Control. 2019 Mar;66(3):517-526. doi: 10.1109/TUFFC.2018.2872067. Epub 2018 Sep 24.
Reference Type
BACKGROUND
Christensen-Jeffries K, Couture O, Dayton PA, Eldar YC, Hynynen K, Kiessling F, O'Reilly M, Pinton GF, Schmitz G, Tang MX, Tanter M, van Sloun RJG. Super-resolution Ultrasound Imaging. Ultrasound Med Biol. 2020 Apr;46(4):865-891. doi: 10.1016/j.ultrasmedbio.2019.11.013. Epub 2020 Jan 21.
Reference Type
BACKGROUND
Abdeyrim A, He S, Zhang Y, Mamtali G, Asla A, Yusup M, Liu J. Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: a systematic review and meta-analysis. J Otolaryngol Head Neck Surg. 2020 May 29;49(1):31. doi: 10.1186/s40463-020-00421-w.
Reference Type
BACKGROUND
Ahuja AT, Ying M, Ho SS, Metreweli C. Distribution of intranodal vessels in differentiating benign from metastatic neck nodes. Clin Radiol. 2001 Mar;56(3):197-201. doi: 10.1053/crad.2000.0574.
Reference Type
BACKGROUND
Andersen SB, Taghavi I, Hoyos CAV, Sogaard SB, Gran F, Lonn L, Hansen KL, Jensen JA, Nielsen MB, Sorensen CM. Super-Resolution Imaging with Ultrasound for Visualization of the Renal Microvasculature in Rats Before and After Renal Ischemia: A Pilot Study. Diagnostics (Basel). 2020 Oct 22;10(11):862. doi: 10.3390/diagnostics10110862.
Reference Type
BACKGROUND
Aykan NF, Ozatli T. Objective response rate assessment in oncology: Current situation and future expectations. World J Clin Oncol. 2020 Feb 24;11(2):53-73. doi: 10.5306/wjco.v11.i2.53.
Reference Type
BACKGROUND
Basile DP, Donohoe D, Roethe K, Osborn JL. Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. Am J Physiol Renal Physiol. 2001 Nov;281(5):F887-99. doi: 10.1152/ajprenal.2001.281.5.F887.
Reference Type
BACKGROUND
Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS. Microvascular Disease, Peripheral Artery Disease, and Amputation. Circulation. 2019 Aug 6;140(6):449-458. doi: 10.1161/CIRCULATIONAHA.119.040672. Epub 2019 Jul 8.
Reference Type
BACKGROUND
Brown M, Assen FP, Leithner A, Abe J, Schachner H, Asfour G, Bago-Horvath Z, Stein JV, Uhrin P, Sixt M, Kerjaschki D. Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice. Science. 2018 Mar 23;359(6382):1408-1411. doi: 10.1126/science.aal3662.
Reference Type
BACKGROUND
Ehling J, Theek B, Gremse F, Baetke S, Mockel D, Maynard J, Ricketts SA, Grull H, Neeman M, Knuechel R, Lederle W, Kiessling F, Lammers T. Micro-CT imaging of tumor angiogenesis: quantitative measures describing micromorphology and vascularization. Am J Pathol. 2014 Feb;184(2):431-41. doi: 10.1016/j.ajpath.2013.10.014. Epub 2013 Nov 18.
Reference Type
BACKGROUND
Ehling J, Babickova J, Gremse F, Klinkhammer BM, Baetke S, Knuechel R, Kiessling F, Floege J, Lammers T, Boor P. Quantitative Micro-Computed Tomography Imaging of Vascular Dysfunction in Progressive Kidney Diseases. J Am Soc Nephrol. 2016 Feb;27(2):520-32. doi: 10.1681/ASN.2015020204. Epub 2015 Jul 20.
Reference Type
BACKGROUND
Errico C, Pierre J, Pezet S, Desailly Y, Lenkei Z, Couture O, Tanter M. Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging. Nature. 2015 Nov 26;527(7579):499-502. doi: 10.1038/nature16066.
Reference Type
BACKGROUND
Eshraghi Samani R, Shirkhoda M, Hadji M, Beheshtifard F, Hamedani SMMG, Momen A, Mollashahi M, Zendehdel K. The prognostic value of lymph node ratio in survival of head-and-neck squamous cell carcinoma. J Res Med Sci. 2018 Apr 26;23:35. doi: 10.4103/jrms.JRMS_948_17. eCollection 2018.
Reference Type
BACKGROUND
Foiret J, Zhang H, Ilovitsh T, Mahakian L, Tam S, Ferrara KW. Ultrasound localization microscopy to image and assess microvasculature in a rat kidney. Sci Rep. 2017 Oct 20;7(1):13662. doi: 10.1038/s41598-017-13676-7.
Reference Type
BACKGROUND
Harput S, Christensen-Jeffries K, Brown J, Li Y, Williams KJ, Davies AH, Eckersley RJ, Dunsby C, Tang MX, Christensen-Jeffries K, Li Y, Williams KJ, Eckersley RJ, Harput S, Dunsby C, Davies AH, Brown J, Tang MX. Two-Stage Motion Correction for Super-Resolution Ultrasound Imaging in Human Lower Limb. IEEE Trans Ultrason Ferroelectr Freq Control. 2018 May;65(5):803-814. doi: 10.1109/TUFFC.2018.2824846.
Reference Type
BACKGROUND
Huang C, Zhang W, Gong P, Lok UW, Tang S, Yin T, Zhang X, Zhu L, Sang M, Song P, Zheng R, Chen S. Super-resolution ultrasound localization microscopy based on a high frame-rate clinical ultrasound scanner: an in-human feasibility study. Phys Med Biol. 2021 Apr 8;66(8):10.1088/1361-6560/abef45. doi: 10.1088/1361-6560/abef45.
Reference Type
BACKGROUND
Jafarnejad M, Ismail AZ, Duarte D, Vyas C, Ghahramani A, Zawieja DC, Lo Celso C, Poologasundarampillai G, Moore JE Jr. Quantification of the Whole Lymph Node Vasculature Based on Tomography of the Vessel Corrosion Casts. Sci Rep. 2019 Sep 16;9(1):13380. doi: 10.1038/s41598-019-49055-7.
Reference Type
BACKGROUND
Jeong HS, Jones D, Liao S, Wattson DA, Cui CH, Duda DG, Willett CG, Jain RK, Padera TP. Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases. J Natl Cancer Inst. 2015 Jun 10;107(9):djv155. doi: 10.1093/jnci/djv155. Print 2015 Sep.
Reference Type
BACKGROUND
Jonasson H, Bergstrand S, Fredriksson I, Larsson M, Ostgren CJ, Stromberg T. Normative data and the influence of age and sex on microcirculatory function in a middle-aged cohort: results from the SCAPIS study. Am J Physiol Heart Circ Physiol. 2020 Apr 1;318(4):H908-H915. doi: 10.1152/ajpheart.00668.2019. Epub 2020 Mar 6.
Reference Type
BACKGROUND
Kierski TM, Espindola D, Newsome IG, Cherin E, Yin J, Foster FS, Demore CEM, Pinton GF, Dayton PA. Superharmonic Ultrasound for Motion-Independent Localization Microscopy: Applications to Microvascular Imaging From Low to High Flow Rates. IEEE Trans Ultrason Ferroelectr Freq Control. 2020 May;67(5):957-967. doi: 10.1109/TUFFC.2020.2965767. Epub 2020 Jan 10.
Reference Type
BACKGROUND
Kim E, Park JS, Son KR, Kim JH, Jeon SJ, Na DG. Preoperative diagnosis of cervical metastatic lymph nodes in papillary thyroid carcinoma: comparison of ultrasound, computed tomography, and combined ultrasound with computed tomography. Thyroid. 2008 Apr;18(4):411-8. doi: 10.1089/thy.2007.0269.
Reference Type
BACKGROUND
Kupferman ME, Patterson DM, Mandel SJ, LiVolsi V, Weber RS. Safety of modified radical neck dissection for differentiated thyroid carcinoma. Laryngoscope. 2004 Mar;114(3):403-6. doi: 10.1097/00005537-200403000-00002.
Reference Type
BACKGROUND
Lee S, Lee JY, Yoon RG, Kim JH, Hong HS. The Value of Microvascular Imaging for Triaging Indeterminate Cervical Lymph Nodes in Patients with Papillary Thyroid Carcinoma. Cancers (Basel). 2020 Oct 1;12(10):2839. doi: 10.3390/cancers12102839.
Reference Type
BACKGROUND
Lin F, Shelton SE, Espindola D, Rojas JD, Pinton G, Dayton PA. 3-D Ultrasound Localization Microscopy for Identifying Microvascular Morphology Features of Tumor Angiogenesis at a Resolution Beyond the Diffraction Limit of Conventional Ultrasound. Theranostics. 2017 Jan 1;7(1):196-204. doi: 10.7150/thno.16899. eCollection 2017.
Reference Type
BACKGROUND
Lowerison M, Zhang W, Chen X, Fan T, Song P. Characterization of Anti-Angiogenic Chemo-Sensitization via Longitudinal Ultrasound Localization Microscopy in Colorectal Carcinoma Tumor Xenografts. IEEE Trans Biomed Eng. 2022 Apr;69(4):1449-1460. doi: 10.1109/TBME.2021.3119280. Epub 2022 Mar 18.
Reference Type
BACKGROUND
Lowerison MR, Huang C, Lucien F, Chen S, Song P. Ultrasound localization microscopy of renal tumor xenografts in chicken embryo is correlated to hypoxia. Sci Rep. 2020 Feb 12;10(1):2478. doi: 10.1038/s41598-020-59338-z.
Reference Type
BACKGROUND
Maric-Bilkan C, Flynn ER, Chade AR. Microvascular disease precedes the decline in renal function in the streptozotocin-induced diabetic rat. Am J Physiol Renal Physiol. 2012 Feb 1;302(3):F308-15. doi: 10.1152/ajprenal.00421.2011. Epub 2011 Oct 26.
Reference Type
BACKGROUND
Opacic T, Dencks S, Theek B, Piepenbrock M, Ackermann D, Rix A, Lammers T, Stickeler E, Delorme S, Schmitz G, Kiessling F. Motion model ultrasound localization microscopy for preclinical and clinical multiparametric tumor characterization. Nat Commun. 2018 Apr 18;9(1):1527. doi: 10.1038/s41467-018-03973-8.
Reference Type
BACKGROUND
Pereira ER, Kedrin D, Seano G, Gautier O, Meijer EFJ, Jones D, Chin SM, Kitahara S, Bouta EM, Chang J, Beech E, Jeong HS, Carroll MC, Taghian AG, Padera TP. Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice. Science. 2018 Mar 23;359(6382):1403-1407. doi: 10.1126/science.aal3622. Epub 2018 Mar 22.
Reference Type
BACKGROUND
Yu J, Lavery L, Kim K. Super-resolution ultrasound imaging method for microvasculature in vivo with a high temporal accuracy. Sci Rep. 2018 Sep 17;8(1):13918. doi: 10.1038/s41598-018-32235-2.
Reference Type
BACKGROUND
Zhu AQ, Li XL, An LW, Guo LH, Fu HJ, Sun LP, Xu HX. Predicting Axillary Lymph Node Metastasis in Patients With Breast Invasive Ductal Carcinoma With Negative Axillary Ultrasound Results Using Conventional Ultrasound and Contrast-Enhanced Ultrasound. J Ultrasound Med. 2020 Oct;39(10):2059-2070. doi: 10.1002/jum.15314. Epub 2020 May 5.
Reference Type
BACKGROUND
Other Identifiers
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SURE-LN-2022
Identifier Type: -
Identifier Source: org_study_id
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