Clinical Trial to Evaluate the Efficacy and Safety of DA-2811 When Added to Ongoing Metformin Monotherapy in Patients with Type 2 Diabetes Who Have Inadequate Glycemic Control

NCT ID: NCT05743907

Last Updated: 2025-03-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

231 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-25

Study Completion Date

2025-03-10

Brief Summary

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This study is a multicenter, double-blind, active-controlled, randomized, parallel, phase IV clinical trial to evaluate the efficacy and safety of DA-2811 when added to ongoing metformin monotherapy in patients with type 2 diabetes who have inadequate glycemic control

Detailed Description

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Conditions

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Diabetes Mellitus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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DA-2811

DA-2811 + Forxiga placebo

Group Type EXPERIMENTAL

DA-2811

Intervention Type DRUG

DA-2811 Group: DA-2811 + Forxiga placebo

Forxiga

Forxiga + DA-2811 placebo

Group Type ACTIVE_COMPARATOR

Forxiga

Intervention Type DRUG

Forxiga Group: Forxiga + DA-2811 placebo

Interventions

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DA-2811

DA-2811 Group: DA-2811 + Forxiga placebo

Intervention Type DRUG

Forxiga

Forxiga Group: Forxiga + DA-2811 placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subjects with 7.0%≤HbA1c≤10.0% at screening
* Subjects treated with 1,000mg/day or higher dose of metformin for at least 8 weeks prior to screening
* Subjects with 18.5kg/m2≤BMI≤40kg/m2 at screening
* Subject who is willing and able to provide informed consent indicating that they understand the purpose and procedures required for the study

Exclusion Criteria

* Subjects with fasting plasma glucose≥240mg/dL at screening
* Patients with type 1 diabetes mellitus, secondary diabetes mellitus or gestational diabetes mellitus
* Subject with ALT and AST 3 times or higher than upper normal range
* Subject with history of myocardial infarction, cerebral infarction within 3 months prior to screening
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dong-A ST Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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The Catholic University of Korea Bucheon St. Mary's Hospital

Bucheon-si, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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DA2811_DM_IV

Identifier Type: -

Identifier Source: org_study_id

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