Discontinuation of Antibiotic Susceptibility Testing on Enterococcus Faecalis Positive Urine Cultures in Hospitalized Patients: an Impact on Antibiotic Prescriptions? (FaecaCible)

NCT ID: NCT05743192

Last Updated: 2023-06-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 217 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-02-15
• Study Completion Date: 2023-06-08

Brief Summary

The objective of the study is to evaluate the impact of not reporting antibiotic susceptibility tests on antibiotic consumption for Enterococcus faecalis positive urine cultures in adult hospitalized patients. The secondary objectives are to evaluate the impact of this intervention on antibiotic prescription rates as well as on antibiotic consumption according to: patient gender, type of antibiotic therapy (probabilistic/documented) and diagnosis (urinary tract infection or colonization). It is hypothesized that antibiotic consumption is lower after the application of the absence of antibiotic susceptibility reporting compared to before.

Conditions

Antibiotic Susceptibility Reporting

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: RETROSPECTIVE

Study Groups

Before group

Group of patients with a positive urine culture for Enterococcus faecalis before the procedure consisting of systematically performing an antibiotic susceptibility test.

No interventions assigned to this group

After group

Group of patients with a positive urine culture for Enterococcus faecalis after the procedure consisting of systematically performing an antibiotic susceptibility test.

Stop performing an antibiotic susceptibility test

Intervention Type: OTHER

Intervention = Stop performing an antibiotic susceptibility test for enterococcus faecalis in urine cultures. It defines two groups : one before and one after the intervention

Interventions

Stop performing an antibiotic susceptibility test

Intervention = Stop performing an antibiotic susceptibility test for enterococcus faecalis in urine cultures. It defines two groups : one before and one after the intervention

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Person having received complete information on the organization of the research and not having objected to the exploitation of these data
• Adult patients (More than 18);
• Having performed a urine culture at the Nancy University Hospital, taken from the 2nd urine stream, by urinary catheter or via a suprapubic catheter and whose culture is positive for monomicrobial E. faecalis with a bacteriuria threshold greater than or equal to 10^3 CFU/field;
• Hospitalized at the Nancy University Hospital at least 72 hours after validation of the antibiotic susceptibility test in the pre-intervention period and at least 72 hours after validation of the culture in the post-intervention period.

Exclusion Criteria

• Inpatients in hematology, critical care/intensive care, consultation and day hospital units;
• Urine cultures performed in ambulatory units ;
• Urine culture performed in the critical care/intensive care/hematology units;
• Patients discharged from hospital/deceased/transferred to intensive care within 72 hours of the validation of the antibiotic susceptibility test or the validation of the urine culture;
• Patients with associated E. faecalis bacteremia;
• Urine culture without an antibiotic susceptibility test for the pre-intervention period;
• Urine culture with a monomicrobial history of less than 1 week;
• Culture of urine from pyelic punctures or nephrostomy tubes - conservation of those from second streams, urinary catheters and suprapubic catheters).

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Central Hospital, Nancy, France

OTHER

Sponsor Role: lead

Responsible Party

BARONNET Guillaume

MD, Infectious diseases department

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Nancy University Hospital

Vandœuvre-lès-Nancy, , France

Countries

France

Other Identifiers

2022PI075

Identifier Type: -

Identifier Source: org_study_id