A Phase 1b/2, Multi-center, Single Arm Study to Assess the Safety and Efficacy of Neoantigen Synthetic Long Peptide Vaccines in Patients With Local Or Metastatic Solid Tumors

NCT ID: NCT05741242

Last Updated: 2026-01-15

Basic Information

• Recruitment Status: ENROLLING_BY_INVITATION
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 136 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-11-30
• Study Completion Date: 2029-01-31

Brief Summary

A Phase 1b/2, Multi-center, Single Arm Study to Assess the Safety and Efficacy of Neoantigen Synthetic Long Peptide Vaccines in Patients With Local Or Metastatic Solid Tumors

Detailed Description

This is a Simon-two stage multi-cohort study to assess the safety and efficacy of neoantigen synthetic long peptide vaccines in patients with local or metastatic solid tumors.

1. To assess the efficacy of NeoSLP vaccination by investigator assessment of Progression-Free Survival at 12 months (PFS12).

2. To assess efficacy of NeoSLP vaccination by assessment of Time to Treatment Failure (TTF).

3. To assess efficacy of NeoSLP vaccination by assessment of Overall Survival at 24 months (OS24).

4. To investigate the immunogenicity of NeoSLP vaccines by ELISpot assay. 5. To assess the safety and tolerability of NeoSLP vaccines.

Conditions

Cancer; Solid Tumor

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Personalized Synthetic Long Peptide Vaccine

Group Type: EXPERIMENTAL

Personalized Synthetic Long Peptide Vaccine

Intervention Type: BIOLOGICAL

Personalized Synthetic Long Peptide Vaccine

Interventions

Personalized Synthetic Long Peptide Vaccine

Personalized Synthetic Long Peptide Vaccine

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

Pancreatic

1. Patients who have local or metastatic pancreatic adenocarcinoma and have started first line therapy of Folfirinox (physician's choice for any concomitant therapies)

2. Patients who have undergone somatic tumor sequencing should consider FDA-approved pan-solid tumor therapies if they harbor an FDA-approved somatic alteration. For example, Entrectinib or Larotrectinib (if NTRK gene fusion- positive), Selpercatinib (if RET gene fusion-positive), Pembrolizumab (if MSI-H, dMMR, or TMB-H[≥10 mut/Mb]), and PARP inhibitors (BRCA mutations).

Glioblastoma

1. Patients who are within 6 months of diagnosis and have detectable disease as determined by investigator assessment at the start of vaccine administration.

Basket

1. Patients with local or metastatic malignancies, limited treatment options, and an estimated 5-year survival of less than 50% are eligible for enrollment in this cohort.

1. >= 12 years of age.

2. ECOG performance status ≤ 2 or Karnofsky score of >=70.

3. Adequate organ function allowing favorable benefit to risk ratio per the treating physician

4. Systemic corticosteroid therapy is permitted provided dosing is no greater than 4 mg per day (dexamethasone or equivalent) on the day of vaccine administration.

5. Ability to understand and willingness to sign an IRB approved written informed consent document.

Exclusion Criteria

1. History of serious adverse reaction to vaccines such as anaphylaxis, hives, or respiratory difficulty or known allergy to a component of the neoantigen synthetic long peptide vaccine.

2. Intercurrent illness requiring chronic use of medications that may interfere with rescue medications for treatment of vaccine-related anaphylaxis or attenuate immune response to vaccine treatment (immunosuppressive therapies).

3. Psychiatric illness or social situations that would limit compliance with study requirements.

4. History of pre-existing immunodeficiency disorder or autoimmune condition requiring immunosuppressive therapy that would preclude response to vaccine.

5. Females of childbearing potential may participate provided they agree to practice abstinence; and, if heterosexually active, agree to use at least 2 highly effective contraceptive methods throughout the study and for 3 months following the last dose of study drug; and have a negative serum pregnancy test.

6. Females of non-childbearing potential must be post-menopausal or have been surgically sterilized.

7. Male subjects with a female partner of childbearing potential must agree to practice abstinence or to use a physician-approved contraceptive method throughout the study and for 3 months following the last dose of study drug.

• Minimum Eligible Age: 12 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Jaime Leandro Foundation for Therapeutic Cancer Vaccines

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Precision NextGen Oncology & Research Center

Beverly Hills, California, United States

Quest Clinical Research

San Francisco, California, United States

Mount Sinai Comprehensive Cancer Center

Miami Beach, Florida, United States

St. Louis Cancer Care

Bridgeton, Missouri, United States

Anna Gattani MD PC

New York, New York, United States

Countries

United States

Other Identifiers

JLF-200

Identifier Type: -

Identifier Source: org_study_id