Safety and Immunogenicity of Pentavalent Meningococcal Conjugate Vaccine (EuNmCV-5) in Healthy Adults Aged 19 to 55 Years Old

NCT ID: NCT05739292

Last Updated: 2023-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-28

Study Completion Date

2023-10-04

Brief Summary

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Phase I study to evaluate safety and immunogenicity in healthy adult subjects following a single dose administration of Meningococcal (Group A, C, W-135, X, and Y)-CRM197 Conjugate vaccine

Detailed Description

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Conditions

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Infection, Meningococcal

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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EuNmCV-5

Healthy adults received 0.5mL single intramuscular dose on Day 0.

Group Type EXPERIMENTAL

EuNmCV-5

Intervention Type BIOLOGICAL

0.5mL single intramuscular dose on Day 0

Menveo

Healthy adults received 0.5mL single intramuscular dose on Day 0.

Group Type ACTIVE_COMPARATOR

Menveo

Intervention Type BIOLOGICAL

0.5mL single intramuscular dose on Day 0

Interventions

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EuNmCV-5

0.5mL single intramuscular dose on Day 0

Intervention Type BIOLOGICAL

Menveo

0.5mL single intramuscular dose on Day 0

Intervention Type BIOLOGICAL

Other Intervention Names

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Meningococcal(Groups A, C, W-135, X, and Y) Conjugate Vaccine Meningococcal(Groups A, C, Y, and W-135) Conjugate Vaccine

Eligibility Criteria

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Inclusion Criteria

* Subjects 19 to 55 years of age
* Written informed consent
* Available for all visits and telephone calls scheduled for the study

Exclusion Criteria

* Previous or suspected disease caused by N. meningitides
* Household and/or intimate exposure to an individual with culture-proven N. meningitides infection within 60 days prior to screening
* Serious acute, chronic or progressive disease as determined by investigator
* History of alcohol or substance abuse
Minimum Eligible Age

19 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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EuBiologics Co.,Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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YJ Choi

Role: STUDY_DIRECTOR

EuBiologics Co.,Ltd

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Kim Y, Bae S, Yu KS, Lee S, Lee C, Kim J, Her H, Oh J. A randomized study to evaluate the safety and immunogenicity of a pentavalent meningococcal vaccine. NPJ Vaccines. 2024 Aug 7;9(1):140. doi: 10.1038/s41541-024-00935-8.

Reference Type DERIVED
PMID: 39112515 (View on PubMed)

Other Identifiers

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EuVCT_MCV102

Identifier Type: -

Identifier Source: org_study_id