FitEx for Endometrial Cancer Survivors: Initial Efficacy

NCT ID: NCT05737745

Last Updated: 2025-05-09

Study Results

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

111 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-01

Study Completion Date

2024-06-20

Brief Summary

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The goal of this clinical trial is to compare physical activity outcomes between endometrial cancer survivors randomized to 1 of 3 conditions: 1) usual care, 2) FitEx, 3) FitEx+yoga. Survivors randomized to FitEx groups will recruit \~3 support team members to complete the intervention with them. The main question\[s\] it aims to answer are:

* Do FitEx groups undertake more physical activity than the usual care group?
* Are there differences in quality of life, self-compassion, flourishing, self-efficacy, social support, habit formation, and fruit /vegetable consumption

Participants will:

* Wear a Fitbit
* Complete surveys
* Participate in 30 minute weekly virtual meetings (FitEx groups only)
* Receive weekly newsletters (FitEx groups only)

Detailed Description

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The purpose of this pilot study is to evaluate the initial efficacy of FitEx, a physical activity tracking and promotion program, and FitEx+yoga for endometrial cancer survivors (ECS), with focus on improvement of moderate-vigorous physical activity (MVPA) at the completion of the 8-week program. Specifically, this project will recruit early stage ECS with obesity to be randomized to 1 of 3 conditions: 1) usual care, 2) FitEx, 3) FitEx+yoga. ECS in either intervention condition will each select \~3 friends or family members to be their support members (minimum 2 and maximum 5). All ECS will receive a Fitbit to track their MVPA. We will then compare secondary ECS outcome measures between intervention and control groups including quality of life, self-compassion, flourishing, self-efficacy, social support, habit formation and fruit/vegetable consumption. Additionally, support team member MVPA (via Fitbit) and secondary outcomes will be compared. We will also explore long-term MPVA and secondary outcomes in all groups at 6 months.

Conditions

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Endometrial Cancer Obesity Sedentary Behavior Quality of Life Survivorship

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Usual care

Endometrial cancer survivors will receive standard survivorship care including a one-time educational newsletter about survivorship physical activity and nutrition recommendations. Fitbits will be given to track physical activity.

Group Type NO_INTERVENTION

No interventions assigned to this group

FitEx-ECS

Endometrial cancer survivors and their support team members (as a group of one survivor and their team) will complete the FitEx-ECS intervention program, with a focus on walking. Fitbits will be given to track physical activity.

Group Type EXPERIMENTAL

Self-monitoring

Intervention Type BEHAVIORAL

Tracking physical activity and fruit/vegetable intake.

Group-dynamics

Intervention Type BEHAVIORAL

Survivors act as team captains, facilitating interactions between themselves and their support team members and providing goal directed feedback.

Weekly virtual sessions- Standard

Intervention Type BEHAVIORAL

Weekly 30 minute virtual sessions include support group/team building sessions and 15 minutes of physical activity.

Newsletters- Standard

Intervention Type BEHAVIORAL

Weekly newsletters support attainment of physical activity and nutrition goals.

FitEx-ECS+ Yoga

Endometrial cancer survivors and their support team members (as a group of one survivor and their team) will complete the FitEx-ECS+yoga intervention program, with a focus on postures, breathwork, and mindfulness. Fitbits will be given to track physical activity.

Group Type EXPERIMENTAL

Self-monitoring

Intervention Type BEHAVIORAL

Tracking physical activity and fruit/vegetable intake.

Group-dynamics

Intervention Type BEHAVIORAL

Survivors act as team captains, facilitating interactions between themselves and their support team members and providing goal directed feedback.

Newsletters- Yoga

Intervention Type BEHAVIORAL

Weekly newsletters support attainment of physical activity and nutrition goals, while including mindfulness principles.

Weekly virtual sessions- Yoga

Intervention Type BEHAVIORAL

Weekly 30 minute virtual sessions include support group/team building sessions and 15 minutes of yoga.

Interventions

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Self-monitoring

Tracking physical activity and fruit/vegetable intake.

Intervention Type BEHAVIORAL

Group-dynamics

Survivors act as team captains, facilitating interactions between themselves and their support team members and providing goal directed feedback.

Intervention Type BEHAVIORAL

Weekly virtual sessions- Standard

Weekly 30 minute virtual sessions include support group/team building sessions and 15 minutes of physical activity.

Intervention Type BEHAVIORAL

Newsletters- Standard

Weekly newsletters support attainment of physical activity and nutrition goals.

Intervention Type BEHAVIORAL

Newsletters- Yoga

Weekly newsletters support attainment of physical activity and nutrition goals, while including mindfulness principles.

Intervention Type BEHAVIORAL

Weekly virtual sessions- Yoga

Weekly 30 minute virtual sessions include support group/team building sessions and 15 minutes of yoga.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

SURIVIVOR

* Diagnosed with early stage (I-II) endometrial cancer, any histology
* Received cancer care at Carilion Clinic after 1/1/2010
* At least 18 years of age
* Have adequate comprehension (reading and writing) of the English language
* Have a BMI ≥ 30 kg/m\^2 at screening
* Have stable internet access or access to a smartphone with internet capabilities
* Meet the requirements of the Physical Activity Readiness Questionnaire(PARQ)
* Have the capacity to provide informed consent and are willing to provide informed consent
* SUPPORT TEAM--
* Were identified by a participant with endometrial cancer as a member of their support system
* Are at least 18 years of age
* Have adequate comprehension (reading and writing) of the English language
* Have stable internet access or access to a smartphone with internet capabilities
* Meet the requirements of the Physical Activity Readiness Questionnaire (PARQ)
* Have the capacity to provide informed consent and are willing to provide informed consent

Exclusion Criteria

SURVIVOR

* Recurrent endometrial cancer
* Meeting physical activity guidelines set forth by the American Cancer Society at screening (greater than 150 minutes/week of moderate physical activity, or greater than 75 minutes/week of vigorous physical activity)
* SUPPORT TEAM: Have functional limitations requiring a walker, wheelchair, scooter, or other walking aid which limits their capacity to engage in the intervention safely
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institutes of Health (NIH)

NIH

Sponsor Role collaborator

National Center for Advancing Translational Sciences (NCATS)

NIH

Sponsor Role collaborator

Virginia Polytechnic Institute and State University

OTHER

Sponsor Role collaborator

Carilion Clinic

OTHER

Sponsor Role lead

Responsible Party

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Shannon Armbruster

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Shannon Armbruster, MD MPH

Role: PRINCIPAL_INVESTIGATOR

Carilion Clinic

Locations

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Carilion Clinic

Roanoke, Virginia, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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UL1TR003015

Identifier Type: NIH

Identifier Source: secondary_id

View Link

IRB-22-1727

Identifier Type: -

Identifier Source: org_study_id

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