Trial Outcomes & Findings for Healthcare Disparities in Alopecia Areata (NCT NCT05727306)
NCT ID: NCT05727306
Last Updated: 2025-06-18
Results Overview
Estimated using logistic regression and reported using adjusted odds ratios
Recruitment status
COMPLETED
Target enrollment
4052231 participants
Primary outcome timeframe
Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participant
Results posted on
2025-06-18
Participant Flow
Of the 4,052,231 adults and children (aged 12+) in the final study population, 6,183 people who developed Alopecia Areata (AA) between 1 January 2009 and 31 December 2018 were matched to 24,718 people without AA.
People that did not develop Alopecia Areata but had a diagnosis of a nonspecific or alopecia alternative condition, or less than 12 months of follow-up available, were excluded from the study.
Participant milestones
| Measure |
People With Alopecia Areata
Children and adults aged 12+ with new onset Alopecia Areata registered with a contributing General practitioner (GP) practice during the study period.
No intervention: Observational analysis of usual care only.
|
People Without Alopecia Areata
Children and adults aged 12+ without Alopecia Areata registered with a contributing GP practice during the study period.
No intervention: Observational analysis of usual care only.
|
|---|---|---|
|
Overall Study
STARTED
|
6183
|
24718
|
|
Overall Study
Aged 18-65 Years Old
|
5293
|
20864
|
|
Overall Study
COMPLETED
|
6183
|
24718
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Healthcare Disparities in Alopecia Areata
Baseline characteristics by cohort
| Measure |
People With Alopecia Areata
n=6183 Participants
Children and adults aged 12+ with new onset Alopecia Areata registered with a contributing General practitioner (GP) practice during the study period.
No intervention: Observational analysis of usual care only.
|
People Without Alopecia Areata
n=24718 Participants
Children and adults aged 12+ without Alopecia Areata registered with a contributing GP practice during the study period.
No intervention: Observational analysis of usual care only.
|
Total
n=30901 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
35 years
n=5 Participants
|
35 years
n=7 Participants
|
35 years
n=5 Participants
|
|
Age, Customized
12-17
|
529 Participants
n=5 Participants
|
2111 Participants
n=7 Participants
|
2640 Participants
n=5 Participants
|
|
Age, Customized
18-29
|
1699 Participants
n=5 Participants
|
6792 Participants
n=7 Participants
|
8491 Participants
n=5 Participants
|
|
Age, Customized
30-49
|
2666 Participants
n=5 Participants
|
10659 Participants
n=7 Participants
|
13325 Participants
n=5 Participants
|
|
Age, Customized
50+
|
1289 Participants
n=5 Participants
|
5156 Participants
n=7 Participants
|
6445 Participants
n=5 Participants
|
|
Sex: Female, Male
Female
|
3342 Participants
n=5 Participants
|
13366 Participants
n=7 Participants
|
16708 Participants
n=5 Participants
|
|
Sex: Female, Male
Male
|
2841 Participants
n=5 Participants
|
11352 Participants
n=7 Participants
|
14193 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
White
|
3205 Participants
n=5 Participants
|
12820 Participants
n=7 Participants
|
16025 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Black
|
241 Participants
n=5 Participants
|
960 Participants
n=7 Participants
|
1201 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Asian
|
1129 Participants
n=5 Participants
|
4515 Participants
n=7 Participants
|
5644 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Other
|
264 Participants
n=5 Participants
|
1047 Participants
n=7 Participants
|
1311 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Not recorded
|
1344 Participants
n=5 Participants
|
5376 Participants
n=7 Participants
|
6720 Participants
n=5 Participants
|
|
Geographic area: Urban, Rural
Urban
|
5150 Participants
n=5 Participants
|
20590 Participants
n=7 Participants
|
25740 Participants
n=5 Participants
|
|
Geographic area: Urban, Rural
Rural
|
913 Participants
n=5 Participants
|
3648 Participants
n=7 Participants
|
4561 Participants
n=5 Participants
|
|
Geographic area: Urban, Rural
Not recorded
|
120 Participants
n=5 Participants
|
480 Participants
n=7 Participants
|
600 Participants
n=5 Participants
|
|
Index of multiple deprivation (IMD)
1 (most deprived)
|
1339 Participants
n=5 Participants
|
5356 Participants
n=7 Participants
|
6695 Participants
n=5 Participants
|
|
Index of multiple deprivation (IMD)
2
|
1277 Participants
n=5 Participants
|
5108 Participants
n=7 Participants
|
6385 Participants
n=5 Participants
|
|
Index of multiple deprivation (IMD)
3
|
1091 Participants
n=5 Participants
|
4356 Participants
n=7 Participants
|
5447 Participants
n=5 Participants
|
|
Index of multiple deprivation (IMD)
4
|
1144 Participants
n=5 Participants
|
4573 Participants
n=7 Participants
|
5717 Participants
n=5 Participants
|
|
Index of multiple deprivation (IMD)
5 (least deprived)
|
1205 Participants
n=5 Participants
|
4818 Participants
n=7 Participants
|
6023 Participants
n=5 Participants
|
|
Index of multiple deprivation (IMD)
Not recorded
|
127 Participants
n=5 Participants
|
507 Participants
n=7 Participants
|
634 Participants
n=5 Participants
|
|
Body Mass Index (BMI), Categorical
< 18.5 Underweight
|
315 Participants
n=5 Participants
|
1303 Participants
n=7 Participants
|
1618 Participants
n=5 Participants
|
|
Body Mass Index (BMI), Categorical
18.5-25 Normal weight
|
2277 Participants
n=5 Participants
|
8842 Participants
n=7 Participants
|
11119 Participants
n=5 Participants
|
|
Body Mass Index (BMI), Categorical
25-30 Overweight
|
1644 Participants
n=5 Participants
|
5901 Participants
n=7 Participants
|
7545 Participants
n=5 Participants
|
|
Body Mass Index (BMI), Categorical
30-35 Class I obesity
|
665 Participants
n=5 Participants
|
2664 Participants
n=7 Participants
|
3329 Participants
n=5 Participants
|
|
Body Mass Index (BMI), Categorical
35-40 Class II obesity
|
245 Participants
n=5 Participants
|
941 Participants
n=7 Participants
|
1186 Participants
n=5 Participants
|
|
Body Mass Index (BMI), Categorical
40+ Class III obesity
|
132 Participants
n=5 Participants
|
496 Participants
n=7 Participants
|
628 Participants
n=5 Participants
|
|
Body Mass Index (BMI), Categorical
Not recorded
|
905 Participants
n=5 Participants
|
4571 Participants
n=7 Participants
|
5476 Participants
n=5 Participants
|
|
Smoking status
Non-smoker
|
2538 Participants
n=5 Participants
|
11676 Participants
n=7 Participants
|
14214 Participants
n=5 Participants
|
|
Smoking status
Active smoker
|
1868 Participants
n=5 Participants
|
5561 Participants
n=7 Participants
|
7429 Participants
n=5 Participants
|
|
Smoking status
Ex-smoker
|
1529 Participants
n=5 Participants
|
5741 Participants
n=7 Participants
|
7270 Participants
n=5 Participants
|
|
Smoking status
Not recorded
|
248 Participants
n=5 Participants
|
1740 Participants
n=7 Participants
|
1988 Participants
n=5 Participants
|
|
Alcohol status
Non-drinker
|
1272 Participants
n=5 Participants
|
4628 Participants
n=7 Participants
|
5900 Participants
n=5 Participants
|
|
Alcohol status
Safe use
|
2750 Participants
n=5 Participants
|
10927 Participants
n=7 Participants
|
13677 Participants
n=5 Participants
|
|
Alcohol status
Hazardous use
|
686 Participants
n=5 Participants
|
2596 Participants
n=7 Participants
|
3282 Participants
n=5 Participants
|
|
Alcohol status
Alcoholism
|
117 Participants
n=5 Participants
|
314 Participants
n=7 Participants
|
431 Participants
n=5 Participants
|
|
Alcohol status
Not recorded
|
1358 Participants
n=5 Participants
|
6253 Participants
n=7 Participants
|
7611 Participants
n=5 Participants
|
|
Geographical region
London
|
1488 Participants
n=5 Participants
|
5952 Participants
n=7 Participants
|
7440 Participants
n=5 Participants
|
|
Geographical region
East Midlands
|
227 Participants
n=5 Participants
|
904 Participants
n=7 Participants
|
1131 Participants
n=5 Participants
|
|
Geographical region
East of England
|
253 Participants
n=5 Participants
|
1009 Participants
n=7 Participants
|
1262 Participants
n=5 Participants
|
|
Geographical region
North East
|
209 Participants
n=5 Participants
|
833 Participants
n=7 Participants
|
1042 Participants
n=5 Participants
|
|
Geographical region
North West
|
1160 Participants
n=5 Participants
|
4640 Participants
n=7 Participants
|
5800 Participants
n=5 Participants
|
|
Geographical region
South East
|
1053 Participants
n=5 Participants
|
4212 Participants
n=7 Participants
|
5265 Participants
n=5 Participants
|
|
Geographical region
South West
|
635 Participants
n=5 Participants
|
2540 Participants
n=7 Participants
|
3175 Participants
n=5 Participants
|
|
Geographical region
West Midlands
|
417 Participants
n=5 Participants
|
1665 Participants
n=7 Participants
|
2082 Participants
n=5 Participants
|
|
Geographical region
Yorkshire and The Humber
|
614 Participants
n=5 Participants
|
2456 Participants
n=7 Participants
|
3070 Participants
n=5 Participants
|
|
Geographical region
Not recorded
|
127 Participants
n=5 Participants
|
507 Participants
n=7 Participants
|
634 Participants
n=5 Participants
|
PRIMARY outcome
Timeframe: Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participantEstimated using logistic regression and reported using adjusted odds ratios
Outcome measures
| Measure |
People With Alopecia Areata
n=6183 Participants
Children and adults aged 12+ with new onset Alopecia Areata registered with a contributing General practitioner (GP) practice during the study period.
No intervention: Observational analysis of usual care only.
|
People Without Alopecia Areata (Reference Group)
n=24718 Participants
Children and adults aged 12+ without Alopecia Areata registered with a contributing GP practice during the study period.
No intervention: Observational analysis of usual care only.
|
|---|---|---|
|
Likelihood of Depressive Episodes
|
1217 Participants
|
3576 Participants
|
PRIMARY outcome
Timeframe: Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participantEstimated using logistic regression and reported using adjusted odds ratios
Outcome measures
| Measure |
People With Alopecia Areata
n=6183 Participants
Children and adults aged 12+ with new onset Alopecia Areata registered with a contributing General practitioner (GP) practice during the study period.
No intervention: Observational analysis of usual care only.
|
People Without Alopecia Areata (Reference Group)
n=24718 Participants
Children and adults aged 12+ without Alopecia Areata registered with a contributing GP practice during the study period.
No intervention: Observational analysis of usual care only.
|
|---|---|---|
|
Likelihood of Recurrent Major Depressive Disorder
|
835 Participants
|
2264 Participants
|
PRIMARY outcome
Timeframe: Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participantEstimated using logistic regression and reported using adjusted odds ratios
Outcome measures
| Measure |
People With Alopecia Areata
n=6183 Participants
Children and adults aged 12+ with new onset Alopecia Areata registered with a contributing General practitioner (GP) practice during the study period.
No intervention: Observational analysis of usual care only.
|
People Without Alopecia Areata (Reference Group)
n=24718 Participants
Children and adults aged 12+ without Alopecia Areata registered with a contributing GP practice during the study period.
No intervention: Observational analysis of usual care only.
|
|---|---|---|
|
Likelihood of Anxiety Disorder
|
1113 Participants
|
3188 Participants
|
SECONDARY outcome
Timeframe: Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participantEstimated using negative binomial regression and reported as adjusted incidence rate ratio
Outcome measures
| Measure |
People With Alopecia Areata
n=6183 Participants
Children and adults aged 12+ with new onset Alopecia Areata registered with a contributing General practitioner (GP) practice during the study period.
No intervention: Observational analysis of usual care only.
|
People Without Alopecia Areata (Reference Group)
n=24718 Participants
Children and adults aged 12+ without Alopecia Areata registered with a contributing GP practice during the study period.
No intervention: Observational analysis of usual care only.
|
|---|---|---|
|
Relative Incidence of Primary Care Attendances
|
39034 Count of primary care visits
|
109052 Count of primary care visits
|
SECONDARY outcome
Timeframe: Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participantEstimated using Cox proportional hazard regression and reported as Adjusted hazard ratio
Outcome measures
| Measure |
People With Alopecia Areata
n=6183 Participants
Children and adults aged 12+ with new onset Alopecia Areata registered with a contributing General practitioner (GP) practice during the study period.
No intervention: Observational analysis of usual care only.
|
People Without Alopecia Areata (Reference Group)
n=24718 Participants
Children and adults aged 12+ without Alopecia Areata registered with a contributing GP practice during the study period.
No intervention: Observational analysis of usual care only.
|
|---|---|---|
|
Relative Incidence of Dermatology Referrals
|
1352 Count of dermatology referrals
|
743 Count of dermatology referrals
|
SECONDARY outcome
Timeframe: Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participantEstimated using Cox proportional hazard regression and reported as adjusted hazard ratio
Outcome measures
| Measure |
People With Alopecia Areata
n=6183 Participants
Children and adults aged 12+ with new onset Alopecia Areata registered with a contributing General practitioner (GP) practice during the study period.
No intervention: Observational analysis of usual care only.
|
People Without Alopecia Areata (Reference Group)
n=24718 Participants
Children and adults aged 12+ without Alopecia Areata registered with a contributing GP practice during the study period.
No intervention: Observational analysis of usual care only.
|
|---|---|---|
|
Relative Incidence Psychological Therapy
|
248 Count of therapy visits
|
672 Count of therapy visits
|
SECONDARY outcome
Timeframe: Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participantUnemployment identified by issue of IB113 or ESA113 forms for unemployment. Relative incidence estimated using Cox proportional hazard regression and reported as Adjusted hazard ratio
Outcome measures
| Measure |
People With Alopecia Areata
n=5293 Participants
Children and adults aged 12+ with new onset Alopecia Areata registered with a contributing General practitioner (GP) practice during the study period.
No intervention: Observational analysis of usual care only.
|
People Without Alopecia Areata (Reference Group)
n=20864 Participants
Children and adults aged 12+ without Alopecia Areata registered with a contributing GP practice during the study period.
No intervention: Observational analysis of usual care only.
|
|---|---|---|
|
Relative Incidence of Unemployment
|
89 Count of unemployment forms issued
|
209 Count of unemployment forms issued
|
SECONDARY outcome
Timeframe: Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participantTime off work identified by recorded issue of Med 3 certificate in primary care. Relative incidence estimated using Cox proportional hazard regression and reported as Adjusted hazard ratio
Outcome measures
| Measure |
People With Alopecia Areata
n=5293 Participants
Children and adults aged 12+ with new onset Alopecia Areata registered with a contributing General practitioner (GP) practice during the study period.
No intervention: Observational analysis of usual care only.
|
People Without Alopecia Areata (Reference Group)
n=20864 Participants
Children and adults aged 12+ without Alopecia Areata registered with a contributing GP practice during the study period.
No intervention: Observational analysis of usual care only.
|
|---|---|---|
|
Relative Incidence of Time Off Work
|
884 Count of Med 3 certificates issued
|
2268 Count of Med 3 certificates issued
|
Adverse Events
People With Alopecia Areata
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
People Without Alopecia Areata
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place