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Volatile Non-Invasive Biomarkers of Epileptic Seizures

NCT ID: NCT05725174

Last Updated: 2024-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

270 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-30

Study Completion Date

2026-11-01

Brief Summary

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Breath and sweat samples will be collected from people who have been admitted to hospital after a potential seizure and analysed by the team. The researchers then hope to identify a pattern of small molecules that can distinguish seizures from other events, and perhaps determine the severity of the seizure.

Detailed Description

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Determining whether someone has had an epileptic seizure, or another event, can be challenging and result in the wrong diagnosis. A 'seizure test' used after the event would therefore be very helpful.

Researchers have used small molecules released from the body in breath and sweat to detect cancers and other diseases; this study will determine whether a similar method can be used to detect whether someone has had an epileptic seizure.

Conditions

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Epilepsy Non-Epileptic Seizure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Sample Collection

Patients will have breath samples collected by blowing into a bag, and sweat samples collected by gauze. These samples will be collected at various timepoints whilst the patients are admitted on the ward.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Patients who have been admitted to either University College London's Queen's Square EEG-telemetry unit or Chalfont Centre for Epilepsy, for diagnosis of seizure events.
2. Patients aged 18 years or above

Exclusion Criteria

1. Patients with active infection or who have taken antibiotics within 4 weeks
2. Patients on immunosuppressive medications
3. Patients with co-morbidities preventing breath collection
4. Patients unable to provide informed consent.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Imperial College London

OTHER

Sponsor Role collaborator

University College London Hospitals

OTHER

Sponsor Role lead

Responsible Party

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Eleonora Lugara

Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Matthew Walker, MB BChir FRCP

Role: PRINCIPAL_INVESTIGATOR

Professor

Locations

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Chalfont Centre for Epilepsy

London, Buckinghamshire, United Kingdom

Site Status RECRUITING

National Hospital for Neurology and Neurosurgery

London, London, United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Eleonora Lugara, PhD

Role: CONTACT

Phone: 02031089108

Email: [email protected]

Grace Luff, MSc

Role: CONTACT

Email: [email protected]

Facility Contacts

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Grace Luff, MSc

Role: primary

Grace Luff, MSc

Role: primary

Matthew Walker, MB BChir FRCP

Role: backup

Other Identifiers

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22/LO/0808

Identifier Type: OTHER

Identifier Source: secondary_id

285913

Identifier Type: -

Identifier Source: org_study_id