Testing the Effectiveness of Cognitive Training Among Depressed Patients Receiving Esketamine Treatment

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-14

Study Completion Date

2028-08-01

Brief Summary

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In a sample of patients already receiving esketamine treatment as part of their clinical care, this project seeks to test whether we can improve depression by introducing helpful information delivered by a computer-based training protocol. This work could ultimately lead to the ability to treat depression more efficiently and with broader dissemination by rapidly priming the brain for helpful forms of learning.

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Detailed Description

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Conditions

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Depression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Cognitive Training

8 sessions of web-based cognitive training

Group Type EXPERIMENTAL

Cognitive Training

Intervention Type BEHAVIORAL

8 sessions of web-based cognitive training

Sham Training

8 sessions of web-based sham training

Group Type SHAM_COMPARATOR

Sham Training

Intervention Type BEHAVIORAL

8 sessions of web-based sham training

Interventions

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Cognitive Training

8 sessions of web-based cognitive training

Intervention Type BEHAVIORAL

Sham Training

8 sessions of web-based sham training

Intervention Type BEHAVIORAL

Eligibility Criteria

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Exclusion Criteria

1. Patients who do not expect to remain located in the Pittsburgh area for a minimum of 1 month beyond study enrollment.
2. Patients who, in the judgment of the esketamine clinical medical director, show signs of intellectual disability, developmental disability, and/or cognitive impairment (including age-related cognitive decline) of a sufficient degree to interfere with engagement in any study procedure.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No