Trial Outcomes & Findings for Re-engagement at Discharge 2 (NCT NCT05694546)

NCT ID: NCT05694546

Last Updated: 2025-08-07

Results Overview

Proportion of discharged patients who are successfully visited after discharge.

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 97 participants
• Primary outcome timeframe: Through three months post-discharge
• Results posted on: 2025-08-07

Participant Flow

Participant milestones

Measure	Community Health Worker Post-Discharge Intervention This group will be offered a community-based visit from a community health worker following hospital discharge. Community Health Worker Post-Discharge Intervention: Clients will be offered a community-based follow-up from a community health worker after hospital discharge.
Overall Study STARTED	97
Overall Study COMPLETED	86
Overall Study NOT COMPLETED	11

Reasons for withdrawal

Measure	Community Health Worker Post-Discharge Intervention This group will be offered a community-based visit from a community health worker following hospital discharge. Community Health Worker Post-Discharge Intervention: Clients will be offered a community-based follow-up from a community health worker after hospital discharge.
Overall Study Lost to Follow-up	11

Baseline Characteristics

Re-engagement at Discharge 2

Baseline characteristics by cohort

Measure	Community Health Worker Post-Discharge Intervention n=97 Participants This group will be offered a community-based visit from a community health worker following hospital discharge. Community Health Worker Post-Discharge Intervention: Clients will be offered a community-based follow-up from a community health worker after hospital discharge.
Age, Continuous	40.7 years STANDARD_DEVIATION 12.4 • n=5 Participants
Sex: Female, Male Female	44 Participants n=5 Participants
Sex: Female, Male Male	53 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants
Race (NIH/OMB) Asian	0 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	97 Participants n=5 Participants
Race (NIH/OMB) White	0 Participants n=5 Participants
Race (NIH/OMB) More than one race	0 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=5 Participants
Region of Enrollment Zambia	97 participants n=5 Participants
CD4 <200	84 Participants n=5 Participants

PRIMARY outcome

Timeframe: Through three months post-discharge

Proportion of discharged patients who are successfully visited after discharge.

Outcome measures

Measure	Community Health Worker Post-Discharge Intervention n=97 Participants This group will be offered a community-based visit from a community health worker following hospital discharge. Community Health Worker Post-Discharge Intervention: Clients will be offered a community-based follow-up from a community health worker after hospital discharge.
Post-Discharge Visits	92 Participants

PRIMARY outcome

Timeframe: Through three months post-discharge

Number of participants that receive a comprehensive discharge follow-up visit from a community health worker

Outcome measures

Measure	Community Health Worker Post-Discharge Intervention n=97 Participants This group will be offered a community-based visit from a community health worker following hospital discharge. Community Health Worker Post-Discharge Intervention: Clients will be offered a community-based follow-up from a community health worker after hospital discharge.
Comprehensive Post-Discharge Visits	67 Participants

PRIMARY outcome

Timeframe: Through three months post-discharge

Proportion of initial post-discharge visits to the HIV clinic that are attended by the participant's community health worker

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 6 months post-discharge

Proportion of clients with suppressed HIV viral load at 6 months post-discharge.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 6 months post-discharge

Proportion of clients alive at 6 months post-discharge.

Outcome measures

Measure	Community Health Worker Post-Discharge Intervention n=97 Participants This group will be offered a community-based visit from a community health worker following hospital discharge. Community Health Worker Post-Discharge Intervention: Clients will be offered a community-based follow-up from a community health worker after hospital discharge.
Mortality Confirmed Alive	77 Participants
Mortality Confirmed Dead	19 Participants
Mortality Lost to Follow Up	1 Participants

SECONDARY outcome

Timeframe: 6 months post-discharge

Retention in HIV care after discharge defined by no gap of >28 days off antiretroviral therapy from discharge date to 6 months post-discharge date

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 1 month post-discharge

Antiretroviral therapy clinic visit within 1 month of discharge

Outcome measures

Outcome data not reported

Adverse Events

Community Health Worker Post-Discharge Intervention

Serious events: 28 serious events

Other events: 0 other events

Deaths: 19 deaths

Serious adverse events

Measure	Community Health Worker Post-Discharge Intervention n=97 participants at risk This group will be offered a community-based visit from a community health worker following hospital discharge. Community Health Worker Post-Discharge Intervention: Clients will be offered a community-based follow-up from a community health worker after hospital discharge.
Surgical and medical procedures Hospital Readmission	28.9% 28/97 • 6 months No difference

Other adverse events

Adverse event data not reported

Additional Information

Cassidy Claassen

University of Maryland Baltimore

Phone: 316-727-6185

Email: cclaassen@ihv.umaryland.edu

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place