A Registry Study of Intracranial Atherosclerotic Stenosis Treatment by Intracranial Drug-eluting Stenting in China

NCT ID: NCT05692882

Last Updated: 2025-04-01

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 1000 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-11-16
• Study Completion Date: 2029-12-30

Brief Summary

The primary objective of this trial is to evaluate the long-term safety and efficacy of the NOVA intracranial drug-eluting stent system in "real world" patients with intracranial atherosclerotic stenosis.

Detailed Description

The investigation is a prospective, multi-center, single arm clinical study. The trial is anticipated to last from December 2022 to December 2030 with 1000 subjects recruited in around 50 Chinese centers. The population for this study is subjects with intracranial atherosclerotic stenosis who are suitable candidates for stent angioplasty. Patients fulfilling all of the inclusion criteria and none of the exclusion criteria will be enrolled after they signed the informed consent form. The study consists of ten visits including preoperative screening, operation date, 30 days, 3, 6 months, 1, 2, 3, 4 years and 5 years. The primary outcome was a composite of stroke or death within 30 days or any ischemic stroke or revascularization from the original culprit intracranial artery beyond 30 days through 12 months after operation.

Conditions

Intracranial Arteriosclerosis; Stenosis Artery; Drug-Eluting Stents; Intracranial Artery Stenosis

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Percutaneous transluminal angioplasty and stenting

All patients will be implanted with Drug-Eluting Stents (NOVA DES).

Group Type: EXPERIMENTAL

Drug-Eluting Stents

Intervention Type: DEVICE

The NOVA stent is a sirolimus-eluting stent system designed for intracranial artery stenosis with a rapid exchangeable balloon

Interventions

Drug-Eluting Stents

The NOVA stent is a sirolimus-eluting stent system designed for intracranial artery stenosis with a rapid exchangeable balloon

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

1. Males or females between 18 and 80 years of age;

2. Symptomatic intracranial arteriosclerosis stenosis with reference diameter 2.25-4.00mm;

3. intracranial artery stenosis ( ≥70%) conformed by digital subtraction angiography (DSA);

4. Those who voluntarily participate in the study and sign informed consent form.

Exclusion Criteria

1. Those who have surgery within previous 30 days or plan to perform major surgery in the next 90 days (surgery grade 3 and above);

2. Subjects of acute hemorrhagic stroke within 3 months;

3. The baseline mRS of disabling stroke is more than 3;

4. The target vessel is severely calcified and closely related to stenosis;

5. Non-atherosclerotic diseases (e.g. arterial dissection, Moya Moya disease, vascular inflammatory lesions caused by infection, autoimmune diseases, post-irradiation, postpartum status; developmental or genetic abnormalities such as fibromuscular dysplasia, sickle cell anemia, suspected vasospasm);

6. It is suspected that the ischemic event is due to embolism or arterial embolism from the extracranial segment (including ipsilateral chest or neck vascular occlusive disease) or potential cardiogenic embolism (e.g. atrial fibrillation, mitral stenosis, patent foramen ovale, left ventricular thrombus, myocardial infarction within 6 weeks, etc.);

7. Target artery's supplying artery stenosis > 50%. For example, patient with middle cerebral artery (MCA) severe stenosis (target artery) and the ipsilateral internal carotid artery (ICA) stenosis > 50% should be excluded; patient with basilar artery (BA) severe stenosis (target artery) and the dominant vertical artery (VA) stenosis > 50% should be excluded;

8. There are intracranial tumors, or intracranial arteriovenous malformations;

9. Those who are allergic to heparin, aspirin, clopidogrel, contrast agents, anesthetics, and stent components;

10. Pregnant and lactating women

11. Those who are unable to complete follow-up because of mental illness, cognitive or emotional disorders;

12. Inapplicable for this study at the investigators' viewpoints.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sino Medical Sciences Technology Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Zhongrong Zhongrong

Role: PRINCIPAL_INVESTIGATOR

Beijing Tiantan Hospital

Locations

First People's Hospital of Chenzhou

Chenzhou, , China

Site Status: RECRUITING

Ganzhou People's Hospital

Ganzhou, , China

Site Status: RECRUITING

Jinhua Municipal Central Hospital

Jinhua, , China

Site Status: RECRUITING

The First Affiliated Hospital of Ningbo University

Ningbo, , China

Site Status: RECRUITING

Shanxi Cardiovascular Hospital

Shanxi, , China

Site Status: RECRUITING

Countries

China

Central Contacts

Zhongrong Miao, MD

Role: CONTACT

zhongrongm@163.com

+8613601243293

Baixue Jia, MD

Role: CONTACT

Facility Contacts

Xiaoxi Yao

Role: primary

Guoyong Zeng

Role: primary

Xiang Bao

Role: primary

Shengjun Zhou

Role: primary

Tao Cheng

Role: primary

Other Identifiers

SN-NOVAII-202202

Identifier Type: -

Identifier Source: org_study_id