Plaque Burden and Ischemia in MINOCA

NCT ID: NCT05681858

Last Updated: 2023-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-08-15

Study Completion Date

2027-08-31

Brief Summary

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The goal of this clinical trial is to assess coronary artery plaque burden, perivascular inflammation and extent of myocardial ischemia in patients presenting with acute myocardial infarction and non-obstructive coronary artery disease. The main question it aims to answer are:

* Identify coronary artery anatomy, plaque burden, composition and high-risk plaque features by CT coronary angiography in MINOCA
* Assess presence, extent and severity of myocardial ischemia in MINOCA

Participants will examined by CT coronary angiography and stress \[12N\] NH3 PET-MR.

Detailed Description

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Conditions

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MINOCA

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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CT coronary angiography and [12N] NH3 PET-MR

All patients will undergo CT coronary angiography and stress \[12N\] NH3 PET-MR

CT coronary angiography and [12N] NH3 PET-MR

Intervention Type DIAGNOSTIC_TEST

Advanced coronary artery plaque analysis, myocardial ischemia and coronary flow reserve

Interventions

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CT coronary angiography and [12N] NH3 PET-MR

Advanced coronary artery plaque analysis, myocardial ischemia and coronary flow reserve

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Acute chest pain
* Elevated troponin
* Non-obstructive coronary arteries by coronary angiography

Exclusion Criteria

* Obstructive coronary artery disease
* Contraindications against CT coronary angiography or stress \[12N\] NH3 PET-MR
* Not able to give informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Haukeland University Hospital

OTHER

Sponsor Role collaborator

Haraldsplass Deaconess Hospital

OTHER

Sponsor Role collaborator

University of Bergen

OTHER

Sponsor Role lead

Responsible Party

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Mai Tone Lønnebakken

Professor M.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Clinical Science, University of Bergen

Bergen, , Norway

Site Status RECRUITING

Countries

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Norway

Facility Contacts

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Mai Tone Lønnebakken, MD phd

Role: primary

Terje H Larsen, MD phd

Role: backup

Other Identifiers

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463549

Identifier Type: -

Identifier Source: org_study_id