Relation Between MicroRNA 203 and 210 and Sparing the Laparoscopic Examination in Cases of Unexplained Infertility

NCT ID: NCT05680350

Last Updated: 2023-01-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-07

Study Completion Date

2022-03-25

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study targets to evaluate the role of estimation of plasma expression levels of gene of microRNAs 203 and 210 in helping to diagnose and grade endometriosis. The study included women with unexplained infertility and clinical picture suggestive of presence of endometriosis were divided randomly into two groups: Control and study groups. All patients underwent exploratory laparotomy for diagnosis and grading of endometriosis if present. Patients of study group gave blood samples for estimation of plasma expression levels of microRNA 203 and 210 using qRT-PCR procedure.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Infertility Unexplained Endometriosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Study group

Study group Patients with unexplained infertility had estimated their Plasma Expression level for Gene"Micro RNA "203 \& 210" by qRT-PCR followed by laparoscopic exploration

Group Type ACTIVE_COMPARATOR

Laparoscopic Exploration

Intervention Type PROCEDURE

Laparoscopic Exploration to diagnose \& grade endometriosis

Estimation of Plasma Expression level of MICRO RNA 203 & 210

Intervention Type DIAGNOSTIC_TEST

estimation of Plasma Expression level for Gene"Micro RNA "203 \& 210" by qRT-PCR

Control Group

Control group Patients with unexplained infertility underwent laparoscopy only

Group Type ACTIVE_COMPARATOR

Laparoscopic Exploration

Intervention Type PROCEDURE

Laparoscopic Exploration to diagnose \& grade endometriosis

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Laparoscopic Exploration

Laparoscopic Exploration to diagnose \& grade endometriosis

Intervention Type PROCEDURE

Estimation of Plasma Expression level of MICRO RNA 203 & 210

estimation of Plasma Expression level for Gene"Micro RNA "203 \& 210" by qRT-PCR

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 30-45 years old
* Unexplained infertility

Exclusion Criteria

* Presence of other causes of infertility,
* age out of the predetermined range,
* the presence of immune disorders,
* maintenance on immunosuppressive drugs
Minimum Eligible Age

30 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Benha University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Amr Sharaf Eldein

Assistant professor of gynecology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Banha University

Banhā, El- Qalyobia, Egypt

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Egypt

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

RC 2.6.2022

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Clinical Study on Endometrial Receptivity
NCT03687021 UNKNOWN EARLY_PHASE1
Surgery and ART For Endometrioma
NCT03717870 NOT_YET_RECRUITING NA
RNA Assays for Endometriosis Detection and Diagnosis
NCT06907303 ENROLLING_BY_INVITATION