Response Prediction in EBV-HLH Using Metabonomics Analysis

NCT ID: NCT05677178

Last Updated: 2023-01-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-01

Study Completion Date

2025-03-01

Brief Summary

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Hemophagocytic lymphohistiocytosis (HLH) is a rare, poorly recognized and underdiagnosed syndrome of excessive immune activation, which is rapidly fatal. Epstein-Barr virus (EBV) is a common trigger of HLH, particularly in Asian individuals. We aim to analyze metabolomics and cytokine profiles of patients before and after treatment to explore the metabolomic characteristics of EBV-HLH, and search for pathogenic mechanisms and therapeutic targets.

Detailed Description

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Hemophagocytic lymphohistiocytosis (HLH) is a rare, poorly recognized and underdiagnosed syndrome of excessive immune activation, which is rapidly fatal. Without early intervention, the median survival time is less than 2 months.Epstein-Barr virus (EBV) is a common trigger of HLH, particularly in Asian individuals. We aim to analyze metabolomics and cytokine profiles of patients before and after treatment to explore the metabolomic characteristics of EBV-HLH, and search for pathogenic mechanisms and therapeutic targets.

Conditions

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Hemophagocytic Lymphohistiocytoses EBV Metabonomics

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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survival group

Patients who survived 2 months after treatment.

observational

Intervention Type OTHER

This study is an observational study without any intervention.

death group

Patients who died 2 months after treatment.

observational

Intervention Type OTHER

This study is an observational study without any intervention.

Interventions

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observational

This study is an observational study without any intervention.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients who meet HLH-04 diagnostic criteria
* EBV-DNA viral load in the peripheral blood \> 500 copies/mL
* Informed consent obtained.

Exclusion Criteria

* refuse to participate.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Beijing Friendship Hospital

OTHER

Sponsor Role lead

Responsible Party

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Zhao Wang

Head of the hematology department

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Zhao Wang, MD

Role: PRINCIPAL_INVESTIGATOR

Beijing Friendship Hospital

Locations

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Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Site Status

Countries

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China

Central Contacts

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Zhao Wang, MD

Role: CONTACT

+861083138303

Other Identifiers

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2022-P2-092-01

Identifier Type: -

Identifier Source: org_study_id

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