A Study to Evaluate the Antiviral Activity and Safety of HH-003 Injection in Subjects With Chronic Hepatitis B and Hepatitis D Co-infection

NCT ID: NCT05674448

Last Updated: 2023-10-10

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 9 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-08-11
• Study Completion Date: 2023-01-04

Brief Summary

This is an open-label phase IIa study of HH-003 to evaluate its antiviral activity and safety in subjects with chronic hepatitis B and hepatitis D co-infection. HH-003 is a human monoclonal antibody targeting the pre-S1 domain of the HBV large envelope protein. It blocks engagement of preS1 with sodium taurocholate co-transporting polypeptide (NTCP), the cellular receptor for HBV/HDV.

Conditions

Chronic Hepatitis B and Hepatitis D Co-infection

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

HH-003 20mg/kg

HH-003 20mg/kg, intravenously, Q2W

Group Type: EXPERIMENTAL

HH-003 20mg/kg

Intervention Type: BIOLOGICAL

HH-003 20mg/kg Q2W intravenously for 24 weeks

HH-003 3mg/kg

HH-003 3mg/kg, intravenously, Q2W

Group Type: EXPERIMENTAL

HH-003 3mg/kg

Intervention Type: BIOLOGICAL

HH-003 3mg/kg Q2W intravenously for 24 weeks

Interventions

HH-003 20mg/kg

HH-003 20mg/kg Q2W intravenously for 24 weeks

Intervention Type: BIOLOGICAL

HH-003 3mg/kg

HH-003 3mg/kg Q2W intravenously for 24 weeks

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

• Signed informed consent form;
• Male or female subjects aged from 18 to 70 years inclusively;
• 18 kg/m2≤BMI≤32 kg/m2, body weight ≥45 kg for men and ≥40 kg for women;
• Positive HBsAg, anti-HDV IgG antibody and HDV RNA at screening;
• Women of childbearing potential or male subjects with female partners of childbearing potential should agree to use an adequate and highly effective contraceptions from screening to the end of study or until 12 weeks after last dose of the study drug (whichever is longer).

Exclusion Criteria

• Be pregnant or lactating at screening;
• Subjects with decompensated liver cirrhosis;
• Subjects with liver dysfunction (including but not limited to ascites, hepatic encephalopathy and upper gastrointestinal bleeding) within 3 months prior to screening;
• Average daily alcohol consumption >40g for men and >20g for women or drug abuse within 6 months prior to screening;
• Subjects with other serious diseases that is inappropriate for study participation per the Investigator's or the Sponsor's discretion (including but not limited to serious cardiac or pulmonary disease, chronic or recurrent urinary disorders, uncontrolled diabetes and autoimmune diseases, epilepsy requiring treatment);
• History of hepatocellular carcinoma (HCC) or hepatocellular carcinoma suggested by liver histopathology or liver imaging;
• Interferon antiviral therapy within 1 year prior to screening.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Huahui Health

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

First Hospital of Jilin University

Changchun, Jilin, China

Countries

China

Other Identifiers

HH003-201

Identifier Type: -

Identifier Source: org_study_id