A Phase III Clinical Trial to Evaluate the Efficacy and Safety of the Live Attenuated Varicella Vaccine

NCT ID: NCT05669625

Last Updated: 2023-06-18

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 12440 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-12-26
• Study Completion Date: 2026-09-14

Brief Summary

The goal of this clinical trial is to evaluate the efficacy, safety and immunogenicity of a live attenuated varicella vaccine manufactured by Beijing Institute of Biological Products Co., Ltd in healthy children.

Detailed Description

This trial is aim to evaluate the efficacy, safety and immunogenicity of a live attenuated varicella vaccine manufactured by Beijing Institute of Biological Products Co., Ltd in healthy children aged 1-12 years old.

This study will be conducted in two stage. the stage 1 adopts an open design, and 20 subjects aged 18~59 and 13~17 years old (18~59 years old→ 13~17 years old, sequentially enrolled) are enrolled, and 1 dose of the trial vaccine is administered to explore safety.

The stage 2 adopts a randomized, blinded, placebo-controlled design, 12400 healthy participants aged 1-12 years old will be randomly assigned into experimental group or control group with the ratio 1:1.

Conditions

Varicella

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: TRIPLE

Study Groups

Experimental Group

Single subcutaneous injection of the investigational vaccine (0.5 ml)

Group Type: EXPERIMENTAL

Investigational live attenuated varicella vaccine

Intervention Type: BIOLOGICAL

0.5 ml/vial

Placebo Group

Single subcutaneous injection of the investigational placebo (0.5 ml)

Group Type: PLACEBO_COMPARATOR

Placebo of live attenuated varicella vaccine

Intervention Type: BIOLOGICAL

0.5 ml/vial

Interventions

Investigational live attenuated varicella vaccine

0.5 ml/vial

Intervention Type: BIOLOGICAL

Placebo of live attenuated varicella vaccine

0.5 ml/vial

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

• Healthy volunteer between 13 - 59 years old for Stage 1, 1-12 years old for Stage 2, and be able to provide legal identification ;
• Subject and/or guardian has the ability to understand study requirements and processes, consent to participate in clinical trials, and sign informed consent forms;
• Consent to use effective contraception during study participation, no pregnancy and no family planning (for women of childbearing potential or their spouses);
• Axillary temperature ≤ 37.0 °C on the day of enrollment;

Exclusion Criteria

• Has received any varicella vaccine before ( Not applicable to Stage 1）;
• Has history of varicella or herpes zoster infection, or contact with varicella/shingles patients or suspected varicella/shingles patients within 30 days before enrollment ( Not applicable to Stage 1）;
• Currently using salicylates (including salicylic acid, aspirin, diflunisalin, p-aminosalicylate (sodium), dicalicylate, benoxate, etc.), or plan to use it for a long time during the study；
• Have had febrile illness (axillary temperature ≥ 38.5 °C) or used antipyretic, analgesic, anti-allergic drugs (such as acetaminophen, ibuprofen, aspirin, loratadine, cetirizine, etc.) 3 days before vaccination；
• Have a history of allergy to vaccine components and excipients or severe drug allergy, such as anaphylactic shock, allergic laryngeal edema, Henoch-Schönlein purpura, thrombocytopenic purpura, local allergic necrosis (Arthus) reaction, severe urticaria, etc；
• Have a history of epilepsy, convulsions or convulsions, and have a family history of severe neurological disease or psychosis
• Immunocompromised or diagnosed with congenital or acquired immunodeficiency, HIV infection, lymphoma, leukemia, systemic lupus erythematosus, rheumatoid arthritis, juvenile rheumatoid arthritis, inflammatory bowel disease, or other autoimmune diseases；
• With severe congenital malformations, hereditary diseases, serious cardiovascular diseases, serious liver/kidney diseases, complicated diabetes, malignant tumors, and severe malnutrition
• Immunosuppressant therapy, such as long-term oral or injectable glucocorticoid therapy (≥ 14 days, dose ≥2 mg/kg/day or ≥20 mg/day or equivalent to prednisone), within 3 months prior to enrollment or planned within 30 days of vaccination, but topical medications (e.g., ointments, eye drops, inhalers, or nasal sprays) are not restricted
• Have received blood/blood-related products or immunoglobulins 3 months prior to vaccination, or plan to use such products 30 days after vaccination；
• Have received a live attenuated vaccine within 30 days prior to the trial vaccine, or any vaccine within 14 days prior to vaccination;
• Asplenectomy or splenectomy due to any condition (e.g. splenectomy);
• Those with a history of thrombocytopenia or other coagulation disorders, which may cause contraindications to subcutaneous injection;
• Suffering from various infectious, purulent or allergic skin diseases;
• Are participating in other investigational or unregistered clinical trials of products (drugs, vaccines or devices, etc.), or have plans to participate in other clinical trials before the end of this clinical trial;
• Has any other factors that are not suitable for participation in the clinical trial in the judgment of the investigator

• Minimum Eligible Age: 1 Year
• Maximum Eligible Age: 59 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Beijing Institute of Biological Products Co Ltd.

INDUSTRY

Sponsor Role: collaborator

Jiangsu Province Center for Disease Control and Prevention

UNKNOWN

Sponsor Role: collaborator

China National Biotec Group Company Limited

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Hongxing Pan

Role: PRINCIPAL_INVESTIGATOR

Jiangsu Province Centers for Disease Control and Prevention

Locations

Sinan County Center for Disease Control and Prevention

Tongren, Guizhou, China

Songtao Miao Autonomous County Center for Disease Control and Prevention

Tongren, Guizhou, China

Yuping Dong Autonomous County Center for Disease Control and Prevention

Tongren, Guizhou, China

Qi County Center for Disease Control and Prevention

Hebi, Henan, China

Wuzhi County Center for Disease Control and Prevention

Jiaozuo, Henan, China

Wuyang County Center for Disease Control and Prevention

Luohe, Henan, China

Pei County Center for Disease Control and Prevention

Xuzhou, Jiangsu, China

Huaiyin District Center for Disease Control and Prevention

Xuzhou, Jiangsu, China

Mianyang Anzhou District Center for Disease Control and Prevention

Mianyang, Sichuan, China

Southern County Center for Disease Control and Prevention

Nanchong, Sichuan, China

Neijiang City Center for Disease Control and Prevention

Neijiang, Sichuan, China

Lancang Lahu Autonomous County Center for Disease Control and Prevention

Pu'er, Yunnan, China

Yanshan County Center for Disease Control and Prevention

Wenshan, Yunnan, China

Countries

China

Other Identifiers

CNBG-BIBP-VZV-07

Identifier Type: -

Identifier Source: org_study_id